Precocious puberty

Neely, E. Kirk; Crossen, Stephanie S.

doi:10.1097/gco.0000000000000099

Cited by 34 publications

(30 citation statements)

References 77 publications

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“…Precocious puberty (PP) currently affects 1 in 5000 children and is 10 times more common in girls [ 1 ]. Previous studies [ 2 ] have reported that the overall PP incidence continues to increase and the puberty development age has shown an advancing trend since the 19th century. Advanced progression of secondary sex characteristics occurs in children with PP leading to compromised adult height, poor social adaptability and emotional disorders.…”

Section: Introductionmentioning

confidence: 99%

Association of PAEs with Precocious Puberty in Children: A Systematic Review and Meta-Analysis

Wen

Liu

Lei

et al. 2015

IJERPH

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Background: Precocious puberty (PP) currently affects 1 in 5000 children and is 10 times more common in girls. Existing studies have tried to detect an association between phathalic acid esters (PAEs) and PP, but the results did not reach a consensus. Objective: To estimate the association between PAEs and children with PP based on current evidence. Methods: Databases including PubMed (1978 to March 2015), OVID (1946 to March 2015), Web of Science (1970 to March 2015), EBSCO (1976 to March 2015), CNKI (1979 to March 2015), WANFANG DATA (1987 to March 2015), CBM (1978 to March 2015) and CQVIP (1989 to March 2015) were searched to identify all case-control studies that determined the exposure and concentration of PAEs and their metabolites in children with PP. Meta-analysis of the pooled standard mean difference (SMD) and odds ratio (OR) with 95% confidence intervals (CI) were calculated. Results: A total of 14 studies involving 2223 subjects were finally included. The pooled estimates showed that PP was associated with di-(2-ethylhexyl)-phthalate (DEHP) exposure (OR: 3.90, 95% CI: 2.77 to 5.49). Besides, the concentration of DEHP (SMD: 1.73, 95% CI: 0.54 to 2.91) and di-n-butyl phthalate (DBP) (SMD: 4.31, 95% CI: 2.67 to 5.95) in the PP group were significantly higher than those in the control group, respectively, while no difference was detected between case and control groups in either serum or urinary concentration of mono-(2-ethylhexyl)-phthalate (MEHP), monobutyl phthalate (MBP), mono(2-ethyl-5-oxohexyl) phthalate(MEOHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), monomethyl phthalate (MMP), monobenzyl phthalate (MBzP) or monoethyl phthalate (MEP). Conclusions: Exposure of DEHP and DBP might be associated with PP risk for girls, however, there is no evidence to show an association between the exposure to most PAE metabolites and PP. Given the moderate strength of the results, well-designed cohort studies with large sample size should be performed in future.

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Section: Introductionmentioning

confidence: 99%

Association of PAEs with Precocious Puberty in Children: A Systematic Review and Meta-Analysis

Wen

Liu

Lei

et al. 2015

IJERPH

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“…In addition and related to replacing the normal-abnormal dichotomy with a depiction of puberty as a nuanced and environmentally permeable process, the model also addresses uncertainty in the scientific literature over whether it is possible to actually mark the moment of onset. Traditionally, the age of onset determines whether a young person is "officially" experiencing puberty in a normal or abnormal way (Eugster & Palmert, 2006;Carel & Leger, 2008;Neely & Crossen, 2014). Typically, ovarian puberty displayed before the age of eight is classified as "precocious puberty" (aka abnormal), and individuals are often administered several tests that may lead to the prescription of drugs that inhibit continued pubertal development (Hayes, 2016).…”

Section: Discussionmentioning

confidence: 99%

The biological, biographical, and biospheric dimensions of puberty onset: Using Bio3Science to frame transdisciplinary health research on puberty

Croog

Montoya

Cunningham

et al. 2020

Exploratory Research in Health

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Introduction: This paper uses the case of puberty to characterize a new health science framework called Bio3Science and to provide an example of how trending research on biosocial mechanisms can be put to use to bridge siloed disciplines as well as the translational gap. Examined as an intricate, open-ended problem of scientific understanding, puberty offers a window to examine how three dimensions of human life – biology, biography, and biosphere – can be understood to shape human health and disease. Methods: Using the Bio3Science framework, a biosocial model of puberty was developed and critiqued by an interdisciplinary group of health science and social science researchers in a design studio setting. Results: The design and critique process resulted in a model and new conceptual framework that depicts puberty as a highly variable life experience that integrates multiple dense interactions and context-specific responses; within this model, the gene regulatory network (GRN) transformed from a biological to a biosocial mechanism, with conceptual and concrete applications. Conclusions: By providing a new, generalizable framework for understanding the integration of biology, biography, and biosphere in health research, opportunities emerge for more interdisciplinary work puberty, but also and more broadly, for more collaborative, inter-epistemological health research through the Bio3Science framework. Keywords: Bio3Science, puberty, biosocial, gene regulatory network, normality

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“…Precocious puberty is divided into three categories: gonadotropin dependent (central); gonadotropin independent (peripheral); and combined (central and peripheral) [6] . In a study by Cisternino et al [33] including 438 female children, the patients were diagnosed as central precocious puberty (97.7%) and peripheral precocious puberty (2.3%).…”

Section: Discussionmentioning

confidence: 99%

Assessment of normal, normal variants and precocious puberty in children referred with signs of early pubertal development to pediatric endocrine unit

Kılınç¹

2019

Haydarpasa Numune Med J

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Introduction: The aim of this study was to evaluate the etiologic distribution and clinical features of children referred to a pediatric endocrinology clinic with signs of early puberty, and to compare clinical, biochemical, and anthropometric properties of the patients followed-up with the diagnosis of precocious puberty and normal variants puberty. Methods: In this single-center study, we included children referred with signs of early puberty between July 2015 and July 2017. We retrospectively evaluated the anthropometric measurements and pubertal status of the patients. In the evaluation of patients with suspected early puberty, biochemical tests, bone age, and pelvic ultrasound were used. If indicated, a standard gonadotropin-releasing hormone stimulation test and brain magnetic resonance imaging were performed. Results: A total of 476 children were referred for evaluation of early puberty. There were 454 (95.3%) females. The mean age of the patients at the time of referral was 8.97±2.5 years for girls and 9.56±0.74 years for boys. Out of 476 children, only 139 (29.2%) had early pubertal development, and the remaining 337 (70.8%) had normal puberty or no puberty. Out of 139 patients, 45 (9.4%) had precocious puberty, 59 (12.3%) had premature thelarche, and 35 (7.3%) had premature adrenarche. Discussion and Conclusion: Most of children referred for the evaluation of early pubertal development showed normal puberty or puberty variants. This study emphasizes the importance of a good diagnostic evaluation of these patients.

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Precocious puberty

Abstract: Although the appropriate threshold age of onset of central puberty remains uncertain, gonadotropin-releasing hormone analog therapy is well tolerated and effective in suppressing luteinizing hormone pulses and ovarian activity.

Cited by 34 publications

References 77 publications

Association of PAEs with Precocious Puberty in Children: A Systematic Review and Meta-Analysis

Association of PAEs with Precocious Puberty in Children: A Systematic Review and Meta-Analysis

The biological, biographical, and biospheric dimensions of puberty onset: Using Bio3Science to frame transdisciplinary health research on puberty

Assessment of normal, normal variants and precocious puberty in children referred with signs of early pubertal development to pediatric endocrine unit

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