Precocious puberty in children

Atta, Irum; Laghari, Taj Muhammad; Khan, Yousuf Aziz; Lone, Saira Waqar; Ibrahim, Mohsina Noor; Raza, Jamal

doi:10.1186/1687-9856-2013-s1-p65

Cited by 13 publications

(12 citation statements)

References 18 publications

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“…In our study the most common cause of CPP was idiopathic (83.33%), the same trend was reported by Irum et al 14 and Cisternino et al 15 However, 4/24 cases in our cohort were found to have underlying brain pathology called neurogenic CPP. Contrastenhanced magnetic resonance imaging (MRI) is recommended in CPP in all boys regardless of age and girls presented less than six years of age, even in the absence of clinically evident neurologic abnormalities.…”

Section: Discussionsupporting

confidence: 91%

Precocious puberty: The clinical profile and the etiological classification of children presented at a tertiary care children’s hospital

et al. 2022

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Objectives: To determine the clinical spectrum and underlying etiologies of children presented with precocious puberty at The Children’s Hospital &The Institute of Child health, Lahore. Methods: It is a retrospective review of all the children presented with precocious puberty over one year, from January 2015 to December 2015; at the department of Paediatric Endocrinology & Diabetes, The Children’s Hospital & The Institute of Child Health, Lahore. Results: Total 43 cases of precocious puberty (PP), with 26 females were reported in one year. Central precocious puberty (CPP) constituted 55.8% (24/43) and was found to be more prevalent in female (22/24). In 20/24 cases (83.3%) of central precocious puberty underlying etiology was idiopathic. Peripheral precocious puberty was found in 19/43 cases (44.1%) with male predominance (15/19). Congenital adrenal hyperplasia was the most frequent (12/19) underlying cause of peripheral precocious puberty in our cohort. Conclusion: Precocious puberty could be a manifestation of underlying serious medical condition. It should be thoroughly evaluated with the aim to diagnose the underlying pathology and to treat them promptly. doi: https://doi.org/10.12669/pjms.38.4.4816 How to cite this:Aftab S, Manzoor J, Mahmood Q, Shaheen T. Precocious puberty: The clinical profile and the etiological classification of children presented at a tertiary care children’s hospital. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.4816 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 91%

Precocious puberty: The clinical profile and the etiological classification of children presented at a tertiary care children’s hospital

et al. 2022

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“…Precocious puberty is a series of abnormal sexual development diseases characterized by the early appearance of adolescent development before eight years old in girls and nine years old in boys. In recent years, the incidence of this disease has significantly increased, and it has become one of the most common endocrine system diseases in children, which seriously affects the physical and mental health of children (Atta et al 2015). Precocious puberty can be divided according to different pathogeneses: gonadotropin releasing hormone (GnRH) dependent precocious puberty (GDPP) and GnRH independent precocious puberty (GIPP).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche

Wang

Shao

et al. 2020

Physiol Res

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This study aims to investigate serum makorin ring finger protein 3 (MKRN3) levels in girls with idiopathic central precocious puberty (ICPP) and premature thelarche (PT), in order to determine whether circulating MKRN3 level is associated with ICPP and PT. A total of 90 girls were enrolled in the study. 30 age-matched girls were allocated for each group (ICPP, PT and healthy controls [HC], respectively). The base LH (B-LH) and E2 levels were higher in ICPP girls than those in HC and PT girls. The peak LH (P-LH) levels and P-LH/P-FSH values were obviously higher in ICPP girls than those in PT girls, while higher peak FSH (P-FSH) levels were detected in PT girls when compared to those in ICPP girls. Kisspeptin levels were lower in HC girls than those in ICPP and PT girls. MKRN3 levels were the highest in HC girls among the three groups. There were relatively strong negative correlations among MKRN3, kisspeptin and P-LH/P-FSH. Circulating MKRN3 can have an important role in the onset of ICPP and PT. However, this should not be used as an independent diagnostic criterion for diagnosing ICPP or differentiating ICPP from PT, but should be used only as an adjunctive diagnostic biomarker.

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“…Precocious puberty is a disease associated with puberty development, which affects the physical and mental health of children [13], causes the incidence rate of obesity to increase, and increases the risk of cardiovascular disease and metabolic diseases in children after adulthood [14]. e etiology of some children with precocious puberty is not clear, and about 15% of children with precocious puberty can develop into central precocious puberty by inducing the rapid maturation of hypothalamus pituitary gonad axis [15,16].…”

Section: Discussionmentioning

confidence: 99%

Acupuncture Improving Early Sexual Development of Girls with Peripheral Precocious Puberty: A Prospective Cohort Study

Liu

Wan

Sun

2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To study primarily on the effect of acupuncture on breast Tanner stage, serum sex hormone level, and TCM symptom scores in girls with peripheral precocious puberty (PPP). Methods. 19 eligible patients diagnosed with PPP received acupuncture intervention for 12 weeks, twice a week for 12 weeks, 24 sessions of acupuncture treatment in all, and then follow-up for 12 weeks. The primary outcome was the change in serum luteinizing hormone (LH) level, follicle-stimulating hormone (FSH) level, and breast Tanner stage at 12-week treatment and 12-week follow-up. Serum estradiol (E2) level and TCM symptom scores were also assessed. Results. Nineteen patients with peripheral precocious puberty were treated with acupuncture. After the 12-week acupuncture intervention, the serum LH level, breast Tanner stage, and TCM symptom scores decreased significantly compared with baseline (P<0.05); the serum FSH and E2 level did not change significantly after the 12-week treatment (P>0.05). After the 12-week follow-up, breast Tanner stage and TCM symptom scores decreased significantly compared with baseline (P<0.05), and there was no statistical difference between serum sex hormone (LH, FSH, and E2) level and baseline level (P>0.05). During the period of acupuncture treatment, no side effects or serious adverse events occurred. Conclusions. Acupuncture is effective in regulating the hormone level and controlling early development process. It may be a viable alternative to the treatment of peripheral precocious puberty in girls. However, further randomized controlled trials are needed.

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Precocious puberty in children

Cited by 13 publications

References 18 publications

Precocious puberty: The clinical profile and the etiological classification of children presented at a tertiary care children’s hospital

Precocious puberty: The clinical profile and the etiological classification of children presented at a tertiary care children’s hospital

Evaluation of Serum Makorin Ring Finger Protein 3 (MKRN3) Levels in Girls With Idiopathic Central Precocious Puberty and Premature Thelarche

Acupuncture Improving Early Sexual Development of Girls with Peripheral Precocious Puberty: A Prospective Cohort Study

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