Preconcentration by solvent removal: techniques and applications

Fornells, Elisenda; Hilder, Emily F.; Breadmore, Michael C.

doi:10.1007/s00216-018-1530-8

Cited by 20 publications

(17 citation statements)

References 75 publications

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“…In these systems, it is important to select a membrane with the right properties to ensure good contact between the solution and the membrane, and adequate pervaporation efficiency. Various approaches to the sample preconcentration stage based on the pervaporation/evaporation have been also developed using microfluidic and paper-based devices [27][28][29]. Many of these approaches are characterized by high preconcentration factors.…”

Section: Introductionmentioning

confidence: 99%

Novel Approach to Sample Preconcentration by Solvent Evaporation in Flow Analysis

et al. 2020

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A preconcentration module operated in flow mode and integrated with a sequential injection system with spectrophotometric detection was developed. Using the system, preconcentration was performed in continuous mode and was based on a membraneless evaporation process under diminished pressure. The parameters of the proposed system were optimized and the system was tested on the example of the spectrophotometric determination of Cr(III). The preconcentration effectiveness was determined using the signal enhancement factor. In the optimized conditions for Cr(III), it was possible to obtain the signal enhancement factors of around 10 (SD: 0.9, n = 4) and determine Cr(III) with precision and intermediate precision of 8.4 and 5.1% (CV), respectively. Depending on the initial sample volume, signal enhancement factor values of about 20 were achieved. Applicability of the developed preconcentration system was verified in combination with the capillary electrophoresis method with spectrophotometric detection on the example of determination of Zn in certified reference materials of drinking water and wastewater. Taking into account the enhancement factor of 10, a detection limit of 0.025 mg L−1 was obtained for Zn determination. Zn was determined with precision less than 6% (CV) and the results were consistent with the certified values.

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Section: Introductionmentioning

confidence: 99%

Novel Approach to Sample Preconcentration by Solvent Evaporation in Flow Analysis

et al. 2020

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“…Recently, more complex sample preconcentration strategies are being exploited to increase the local analyte concentrations close to the receptors (i.e., to achieve c s ≈ C 0 ). These strategies include the use of magnetic bead-based immuno-affinity techniques, electrostatic interaction-based capture and dielectrophoretic techniques. − However, these operational variables can only be tuned up to a certain extent, as defined by the detection speed limits set by the functionalities of the receptors. Therefore, it is important to understand how and what molecular variables can be enhanced and up to what extent in order to further improve the efficiency of the microfluidic sensors.…”

Section: Reaching the Detection Speed Limitmentioning

confidence: 99%

Toward the Development of Rapid, Specific, and Sensitive Microfluidic Sensors: A Comprehensive Device Blueprint

Sathish

Shen

2021

JACS Au

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Recent advances in nano/microfluidics have led to the miniaturization of surface-based chemical and biochemical sensors, with applications ranging from environmental monitoring to disease diagnostics. These systems rely on the detection of analytes flowing in a liquid sample, by exploiting their innate nature to react with specific receptors immobilized on the microchannel walls. The efficiency of these systems is defined by the cumulative effect of analyte detection speed, sensitivity, and specificity. In this perspective, we provide a fresh outlook on the use of important parameters obtained from well-characterized analytical models, by connecting the mass transport and reaction limits with the experimentally attainable limits of analyte detection efficiency. Specifically, we breakdown when and how the operational (e.g., flow rates, channel geometries, mode of detection, etc.) and molecular (e.g., receptor affinity and functionality) variables can be tailored to enhance the analyte detection time, analytical specificity, and sensitivity of the system (i.e., limit of detection). Finally, we present a simple yet cohesive blueprint for the development of high-efficiency surface-based microfluidic sensors for rapid, sensitive, and specific detection of chemical and biochemical analytes, pertinent to a variety of applications.

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“…Nevertheless, many of the colorimetric sensing methods that have been developed are not sensitive enough to detect at extremely low detection limits (in the ppb range) and will require some form of preconcentration. 12,13 Several methods of preconcentration have been developed for both analytical purposes 14 and environmental remediation. 15 These methods concentrate the solute of interest from a large volume of solvent and provide a viable and versatile way to increase the concentration of the analyte of interest to reach the detection range of the colorimetric dyes.…”

Section: ■ Introductionmentioning

confidence: 99%

Colorimetric Detection of Heavy Metal Ions Using Superabsorptive Hydrogels and Evaporative Concentration for Water Quality Monitoring

Fathalla

Selvaganapathy

2022

ACS EST Water

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Prevalence of high levels of metal ions in natural and drinking water is a growing problem to both ecosystems and human health. Several methods are broadly used for heavy metal monitoring in water resources, but most of them are laboratory-based. Here, we describe a method that simplifies the measurement process by enabling passive aliquoting and preconcentration of heavy metals. We use superabsorbent polymer beads that can take up hundreds of times their volume to aliquot the sample and preconcentrate the ionic species present in them by 2 orders of magnitude. We then use commercially available colorimetric dyes that are sensitive only at high concentrations to reveal a visible range change in the bead color that can be measured optically using a camera. Using this approach, we have detected the concentration of copper(II) ions in water as low as 5.4 ppb. We demonstrate that this method can also be used for drinking water and tap water samples to assess concentrations of copper and iron. This solid-state method significantly simplifies the analytical procedure and provides extremely low detection levels of heavy metals, eliminating the need for expensive equipment and hence could be useful in remote settings.

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Preconcentration by solvent removal: techniques and applications

Cited by 20 publications

References 75 publications

Novel Approach to Sample Preconcentration by Solvent Evaporation in Flow Analysis

Novel Approach to Sample Preconcentration by Solvent Evaporation in Flow Analysis

Toward the Development of Rapid, Specific, and Sensitive Microfluidic Sensors: A Comprehensive Device Blueprint

Colorimetric Detection of Heavy Metal Ions Using Superabsorptive Hydrogels and Evaporative Concentration for Water Quality Monitoring

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