Preconcentration of diluted biochemical samples using microchannel with integrated nanoscale Nafion membrane

Chao, C.C.; Chiu, Ping Hsien; Yang, Ruey-Jen

doi:10.1007/s10544-015-9940-2

Cited by 22 publications

(15 citation statements)

References 51 publications

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“…If the initial analyte concentration is much lower than the buffer concentration, impressive (several orders of magnitude) degrees of local analyte preconcentration can be achieved. This has been confirmed both theoretically and experimentally . Along with high preconcentration degrees, it is beneficial to have as little analyte lost to waste through the nanochannel as possible.…”

Section: Subcritical Concentrationsmentioning

confidence: 58%

Current‐Induced Concentration Polarization of Nanoporous Media: Role of Electroosmosis

Yaroshchuk

Bondarenko

2018

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Current-induced concentration polarization of nanoporous media is explored theoretically by using approach of local thermodynamic equilibrium within nanopore cross-sections. The problem is solved in quadratures in terms of irreversible thermodynamics. The phenomenological coefficients are further specified by using capillary space-charge model for straight slit-like and cylindrical capillaries. This analysis reveals several novel features of current-induced concentration polarization related to the (electro)osmotic volume transfer. It confirms the previous finding that volume transfer can suppress the limiting-current phenomena but obtains more accurate criteria for this. In particular, it shows that the critical nanopore size and/or electrolyte concentration depend on the nanoporous-medium relative thickness. Under no-limiting-current conditions, the salt concentration at the interface between nanoporous medium and unstirred layer is a nonmonotone function of current density. This gives rise to unconventional current-voltage characteristics. Moreover, under certain conditions, the analysis predicts the existence of ranges of "prohibited" current densities where the problem does not have 1D stationary solution, which could give rise to a kind of "phase separation" with coexisting zones of different local current densities corresponding to the same voltage. Besides the advanced understanding of current-induced concentration polarization of nanoporous media, this analysis provides guidelines for the optimization of sample preconcentration systems in (bio)chemical microanalysis.

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Section: Subcritical Concentrationsmentioning

confidence: 58%

Current‐Induced Concentration Polarization of Nanoporous Media: Role of Electroosmosis

Yaroshchuk

Bondarenko

2018

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“…Three regions are identified, Omic current (region I), limiting current (region II) and over‐limiting current regions (region III). Redrawn from with permission from Springer.…”

Section: Existing Sample Preconcentration Methodsmentioning

confidence: 99%

“…Chao et al. presented a microfluidic preconcentration device incorporating a surface‐patterned nanoscale Nafion membrane. The performance of the proposed device was evaluated and compared for two different microchannel designs, namely straight and convergent.…”

Section: Existing Sample Preconcentration Methodsmentioning

confidence: 99%

Sample preconcentration from dilute solutions on micro/nanofluidic platforms: A review

Hou

Chiu

et al. 2017

Electrophoresis

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Biochemical detection plays a critical role in many analytical fields. For example, blood samples include many proteins with relevance to disease diagnosis and therapeutic monitoring. Foods and beverages contain a large number of chemicals and compounds which must be quantified and characterized to ensure their compliance with safety standards. Detecting trace amounts of contaminants in ambient air or water samples is essential in monitoring the environment and protecting human health. Therefore, effective techniques for performing the rapid and reliable detection of targeted analytes are required. Compared to conventional macroscale devices, microfluidic systems have many advantages, including a greater sensitivity, a faster response time, a reduced sample and reagent consumption, and a greater portability. Accordingly, many microfluidic systems for sample detection have been proposed in recent years. The performance of such devices relies on the target analyte being present in a sufficient concentration to enable its detection. In many biomedical, food testing and environmental applications, the detection limit was restricted. Thus, the sample must first be concentrated before the detection process is carried out. Accordingly, this review provides a comprehensive review of recent advances for sample preconcentration with emphasis on utilizing ion concentration polarization (ICP) effects in micro/nanofluidics platforms. We start with a brief introduction regarding the importance of preconcentration using micro/nanofluidics platforms, followed by in-depth discussions of the ICP effects for the preconcentration and applications to biomedical analysis, food testing and environmental monitoring. Finally, the article concludes with a brief perspective on the future development of the field.

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“…These devices deviate from the simple linear micro-/nanoporous configuration described above because current passes from the sample channel through perpendicular channels containing ion-exchange materials. [12][13][14][15] These ion-permselective patches resemble bipolar electrodes. Thus, trace coions accumulate near this region.…”

Section: Introductionmentioning

confidence: 99%

Highly Selective Current‐Induced Accumulation of Trace Ions at Micro‐/NanoPorous Interfaces

Bondarenko

Bruening

Yaroshchuk

2019

Advcd Theory and Sims

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During application of electrical current through composite micro-/nanoporous membranes, trace-ion accumulation in the microporous layer should vary greatly with the ion diffusion coefficient to allow selective accumulation of specific ions. This study examines the theoretical enrichment factors in the microporous region as a function of current density and trace-ion diffusion coefficient. Trace-ion accumulation relies on charged nanopores that exclude coions, which gives rise to depletion of the dominant salt and high local electric fields in the region next to the nanopores. Trace ions accumulate in this region because convection carries them toward the nanoporous interface, whereas electromigration in the opposite direction is strongest next to the interface. With monovalent coions having 2% difference in diffusion coefficients, calculated accumulation selectivity factors reach >1.2. Such selectivities may prove useful in separating very similar species such as isotopes or equally charged peptides.

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Preconcentration of diluted biochemical samples using microchannel with integrated nanoscale Nafion membrane

Cited by 22 publications

References 51 publications

Current‐Induced Concentration Polarization of Nanoporous Media: Role of Electroosmosis

Current‐Induced Concentration Polarization of Nanoporous Media: Role of Electroosmosis

Sample preconcentration from dilute solutions on micro/nanofluidic platforms: A review

Highly Selective Current‐Induced Accumulation of Trace Ions at Micro‐/NanoPorous Interfaces

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