Preconception-Health-Related Attitudes of Bulgarian Women of Reproductive Age

Hristova-Atanasova, Eleonora; Искров, Георги; Raycheva, Ralitsa; Mandova, Viktoriya; Стефанов, Румен

doi:10.3390/healthcare11070989

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…In addition to these thrombophilic disorders, there are various variables that increase the risk of thromboembolism. Significant contributions to the condition include a high body mass index (BMI), multiple pregnancies, infections, preeclampsia, being immobile during pregnancy, and being of advanced maternal age [ 6 ]. The combination of these factors can lead to different obstetric complications, such as habitual abortions, fetal death, restricted fetal growth, placental disorders such as calcification or abruption, and hypertension disorders, resulting in conditions such as preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Overcoming Recurrent Miscarriages in a 35-Year-Old Female With Thrombophilia

Hristova

2024

Cureus

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Thrombophilias, which include both hereditary and acquired illnesses, are a range of abnormalities that make persons more prone to developing thromboembolism. Thrombophilic conditions carry significant dangers during pregnancy, such as miscarriage in early pregnancy, intrauterine growth restriction, abruptio placenta, and preeclampsia. According to compiled statistics, an average of 15%-20% of pregnancies end in miscarriage. While the risk of miscarriage in a first pregnancy is 11%, this risk increases to between 13% and 17% in subsequent pregnancies, and after the third miscarriage, it reaches 38%. This research article presents a detailed case report that focuses on a patient who has experienced three previous failed pregnancies. The patient's genetic analysis indicates that she has two copies of a mutated version of the methylenetetrahydrofolate reductase ( MTHFR ) gene (Ala222Val) and a variation in the plasminogen activator inhibitor 1 ( PAI-1 ) gene known as 4G/5G. In addition, an evaluation of immunological characteristics revealed increased amounts of natural killer (NK) cells with enhanced activity, along with the identification of embryotoxins in a blood test that suppress embryotoxicity in a blood test, assisted by DNA isolation and real-time polymerase chain reaction (PCR) DNA analysis.

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Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the levels of protein C and antithrombin III demonstrate negligible fluctuation during pregnancy. The reported rise in plasminogen activator inhibitor (PAI) levels is very important because it makes it harder for the mother's blood to flow and break up blood clots [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Overcoming Recurrent Miscarriages in a 35-Year-Old Female With Thrombophilia

Hristova

2024

Cureus

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A comparative analysis of the sexual culture and behavior of nursing students from the Medical University of Plovdiv in the period 2009-2019

Taneva,

Kirkova-Bogdanova,

Vladimirova

et al. 2023

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Introduction: Population reproduction and family planning are highly dependent on sexual culture and sexual behavior. In this study, we seek to determine whether, over a ten-year period from 2009 to 2019, there have been any changes in the sexual culture of nursing students in relation to the knowledge of risk factors for unintended pregnancies and subsequent abortions. Materials and methods: A group anonymous survey was used to gather primary data from 219 nursing students from the Medical College at the Medical University of Plovdiv in 2009 and 210 nursing students from the Faculty of Public Health at the same institution in 2019. The studies in both cohorts were cross-sectional. Results and discussion: We found that students’ perceptions of sexual culture did not change significantly in the study period. There were some changes in the students’ attitudes toward voluntary abortion in the ten years between 2009 and 2019. Age and marital status were found to be essential factors in determining whether an unplanned pregnancy would be maintained or aborted. Future medical professionals are aware of how having an abortion affects a woman’s health and ability to reproduce. Conclusions: In promoting sexual and reproductive health, medical professionals play a crucial role. It is, therefore, essential that a course on sexual health be added to the curriculum of medical universities training healthcare professionals.

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Therapeutic Value of Low-Dose Acetylsalicylic Acid for the Prevention of Preeclampsia in High-Risk Bulgarian Women

Stoilov,

Uchikova,

Kirovakov

et al. 2024

Cureus

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IntroductionPreeclampsia (PE) is a syndrome that affects pregnant women after 20 weeks of gestation and involves numerous organ systems. Screening for PE is essential to prevent complications and guide management. Some existing guidelines for screening have limitations in terms of detection rates and false positives. The aim of this study is to assess the therapeutic value of low-dose acetylsalicylic acid (ASA) for the prevention of PE in high-risk Bulgarian women. MethodologyA prospective cohort research was carried out, encompassing women who were recruited from several routine consultations, such as booking, scanning, and regular prenatal visits. We utilized the purposive sampling technique to carefully choose potential participants. The study was conducted by a maternal-fetal medicine center located in Plovdiv, Bulgaria. The data-gathering period spanned from January 2018 to November 2020. At the appointment, the following procedures were conducted: 1) recording history; 2) assessing height, weight, and blood pressure; 3) collecting blood specimens for biochemical markers; and 4) ultrasound examination. ResultsA total sample size of 1,383 individuals was categorized into two distinct groups: high-risk patients (n = 506) and low-risk patients (n = 877). The mean uterine artery pulsatility index (UtA-PI) and mean arterial pressure (MAP) ratios were all greater in high-risk group women (p < 0.05). The data revealed that a significant number of high-risk women failed to adhere to the prescribed dosage or regular use of ASA as recommended by their doctor. There were only 384 (75.9%) high-risk women who took low-dose ASA regularly. ConclusionThe findings emphasize the importance of personalized prenatal care and early risk assessment to improve maternal and fetal outcomes. Therefore, it is crucial to educate pregnant women, considering the benefits and risks of low-dose ASA when appropriately indicated.

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Preconception-Health-Related Attitudes of Bulgarian Women of Reproductive Age

Cited by 5 publications

References 46 publications

Overcoming Recurrent Miscarriages in a 35-Year-Old Female With Thrombophilia

Overcoming Recurrent Miscarriages in a 35-Year-Old Female With Thrombophilia

A comparative analysis of the sexual culture and behavior of nursing students from the Medical University of Plovdiv in the period 2009-2019

Therapeutic Value of Low-Dose Acetylsalicylic Acid for the Prevention of Preeclampsia in High-Risk Bulgarian Women

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