Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring

Fant, Bruno; Wimmer, Mathieu E.; Swinford-Jackson, Sarah E.; Maurer, John J.; Nest, Duncan Van; Pierce, R. Christopher

doi:10.1007/s00213-019-05307-y

Cited by 13 publications

(3 citation statements)

References 43 publications

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“…Multiple logistic regression analyses were undertaken in 840 trios of parent-child assessing the association of paternal opioid consumption with offspring BMI and the plasma lipid components (triglyceride, cholesterol and HDL). Despite the high rate of substance use among parents and its burden on public health care, epidemiological studies have mainly focused on the offspring neonatal withdrawal syndrome and short-term effects in the offspring, or are mainly limited to the psychological and neurological symptoms 12,15,[26][27][28] . However, evidences so far support the notion that parental substance use (cocaine and alcohol) may exert long effects on offspring metabolism modifying the risk of adult-onset disease such as diabetes 9 .…”

Section: Discussionmentioning

confidence: 99%

Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profile

Jalali

Bahrampour

Khalili

et al. 2021

Sci Rep

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A growing body of evidence suggests that opioid use may affect consumer’s offspring by second-hand passive smoke exposure, as well as by transgenerational impacts mediated by genetic and epigenetic alterations of paternal gametes. In human studies, these effects are limited to investigating the neural, behavioral and cognitive characteristics of offspring. Only animal studies have investigated the metabolic parameters influenced by passive opium smoke exposure. Here, we conducted population-based analyses aimed to estimate the association of paternal opioid consumption, started before or after child birth, with BMI status and plasma lipid profile of young adult offspring. The present study includes 840 parents-offspring trios (offspring aged 15–35, parents aged 35–70) who participated in the prospective Rafsanjan Cohort Study (RCS)—a city in the south-east of Iran—as one of the district areas of the PERSIAN cohort (Prospective Epidemiological Research Studies in IrAN). All procedures for interviews, anthropometric measurements and physical examinations, biological sample collection and laboratory tests for blood biochemical parameters were conducted according to the PERSIAN cohort protocol, and in the well-established RCS setting. Crude and adjusted multiple logistic regression analysis were conducted to assess the relationship of paternal regular opioid use with offspring’s BMI status, and plasma lipid factors. The prevalence of fathers who use opioids regularly among the studied trios was 42.8% (360/840). Our regression analyses demonstrated that paternal opioid use started pre-fatherhood is associated with 76% higher adjusted odds ratio (OR) of overweight/obesity in young offspring (adjusted OR 1.76 (95% CI 1.15–2.71)), adjusting for sex, age, parental BMIs, paternal smoking status and socioeconomic status index (WSI). This relationship persisted when fathers who used opioid by routes other than inhaling (oral) were excluded from logistic analysis (adjusted OR 1.73 (95% CI 1.12–2.68)). Interestingly, sex stratified analysis displayed a 201% increased odds ratio of overweight/obesity in sons of fathers who use opioid regularly, started after child birth (Adjusted OR 3.01 (95% CI 1.68–5.39), while no significant association was found in daughters (adjusted OR 0.74 (95% CI 0.35–1.54)). Additionally, increasing exposure–response relationships were observed between odds ratios of overweight/obesity and the number of years of paternal opioid use after birth (p-trend = 0.0008). Paternal regular opioid use started pre-fatherhood was associated with 54% lowered risk of underweight [adjusted OR 0.46 (95% CI 0.24–0.86)]. Finally, paternal opioid consumption started either before or after child birth did not show a significant association with the high level of the three parameters of plasma lipid factors (triglyceride, cholesterol and HDL-cholesterol) in offspring. Our results suggest that the environmental impacts of paternal regular opioid use may be sufficient to make an effect on male offspring metabolism independent of genetic and epigenetic impact on gametes.

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Section: Discussionmentioning

confidence: 99%

Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profile

Jalali

Bahrampour

Khalili

et al. 2021

Sci Rep

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“…Additionally, the use of psychostimulants such as methylphenidate during pregnancy has been linked to birth defects and limb abnormalities in offspring (4). There has also been considerable evidence that addictive substances such as opioids (5), alcohol (6-8), cannabis (9), psychostimulants (10)(11)(12), and nicotine (13,14), acting on the mesolimbic dopamine reward pathway, affecting behaviors such as anxiety, learning, memory, and cravings in offspring (15). In addition to maternal effects, recent literature has also highlighted epigenetic features inherited from fathers (16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Paternal Preconception Donepezil Exposure Enhances Learning in Offspring

Fan,

Pan,

et al. 2024

Preprint

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Background Recent research has indicated that parental use of central nervous system-targeting medications during periconceptional periods may affect offspring across various developmental and behavioral domains. The present study sought to investigate the potential influence of paternal use of donepezil, a specific reversible central acetylcholinesterase inhibitor that activates the cholinergic system to promote cognition, on offspring. Results In this study, male rats were bred after 21 days of oral donepezil administration at a dose of 4 mg/kg to generate F1 offspring. Both male and female F₁ offspring displayed enhanced performance in learning and short-term memory tests, including novel object recognition, Y maze, and operant learning. Transcriptomic analysis revealed notable alterations in genes associated with the extracellular matrix in the hippocampal tissue of the F1 generation. Integration with genes related to intelligence identified potential core genes that may be involved in the observed behavioral enhancements. Conclusions These findings indicate that prolonged paternal exposure to donepezil may enhance the learning and memory abilities of offspring, possibly by targeting nonneural, extracellular regions. Further research is required to fully elucidate any potential transgenerational effects.

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“…Prenatal exposure to these substances can have a profound impact on adult offspring. It is well-established that substance use during pregnancy can negatively impact cognition ( 2 , 3 ), the stress response ( 4 ), anxiety ( 5 , 6 ), and susceptibility to drug addiction ( 7 , 8 ) in the adult offspring. These transgenerational effects involve epigenetic mechanisms (DNA methylation, histone acetylation, micro RNA) ( 9 – 11 ) as well as drug-induced changes in endocrine function ( 12 , 13 ), receptor expression ( 14 – 16 ), and structural changes within the brain ( 17 , 18 ) that can have pathological consequences extending into adulthood.…”

Section: Introductionmentioning

confidence: 99%

Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?

Rorabaugh

2021

Front. Cardiovasc. Med.

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Prenatal exposure to an adverse uterine environment can have long lasting effects on adult offspring through DNA methylation, histone acetylation, and other epigenetic effects that alter gene expression and physiology. It is well-known that consumption of CNS stimulants such as caffeine, nicotine, amphetamines, and cocaine during pregnancy can adversely impact the offspring. However, most work in this area has focused on neurological and behavioral outcomes and has been limited to assessments in young offspring. The impact of prenatal exposure to these agents on the adult cardiovascular system has received relatively little attention. Evidence from both animal and human studies indicate that exposure to CNS stimulants during the gestational period can negatively impact the adult heart and vasculature, potentially leading to cardiovascular diseases later in life. This review discusses our current understanding of the impact of prenatal exposure to cocaine, methamphetamine, nicotine, and caffeine on the adult cardiovascular system.

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Preconception maternal cocaine self-administration increases the reinforcing efficacy of cocaine in male offspring

Cited by 13 publications

References 43 publications

Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profile

Cohort-based analysis of paternal opioid use in relation to offspring’s BMI and plasma lipid profile

Paternal Preconception Donepezil Exposure Enhances Learning in Offspring

Does Prenatal Exposure to CNS Stimulants Increase the Risk of Cardiovascular Disease in Adult Offspring?

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