Modeling and SimulationIn modeling the fuel cycle of the MSDR, it is important to appropriately capture the time-dependent change in the isotopic composition of the fuel salt undergoing irradiation, feeding, and processing. The isotopic composition change is a function of the initial composition, flux spectrum, fueling rates, and effective removal rates of important isotopes. While the initial composition, fueling rate, and removal rates are defined, the flux spectrum is obtained from a separate reactor physics calculation.To generate an appropriate time-dependent fuel salt composition, the flux spectrum must represent the average flux spectrum experienced by the salt within the core. Several approaches may be taken to ensure that this is the case: (1) perform depletion using a full-core model, or (2) generate a representative