2018
DOI: 10.1007/s00429-018-1800-4
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Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats

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Cited by 33 publications
(34 citation statements)
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“…EP + provides significant protection against acute cerebral ischemic injury (present results and 31). EP + induces brain ischemic tolerance through the promotion of angiogenesis, mediation of inflammatory responses, and inhibition of neuronal apoptosis.…”
Section: Discussionsupporting
confidence: 63%
“…EP + provides significant protection against acute cerebral ischemic injury (present results and 31). EP + induces brain ischemic tolerance through the promotion of angiogenesis, mediation of inflammatory responses, and inhibition of neuronal apoptosis.…”
Section: Discussionsupporting
confidence: 63%
“…The γ member of the 14-3-3 family exerts pleiotropic effects during various physiological processes, such as cell proliferation and anti-apoptosis 54,55 ) . Our previous study demonstrated that preconditioning exercise activates HIF-1α and 14-3-3γ in neurons and astrocytes and subsequently induced neuron-and astrocyte-mediated brain tolerance 35 ) . The upregulated 14-3-3γ induced by precondition-ing exercise reduces ischemic neuronal cell death through the 14-3-3γ/p-β-catenin Ser37/Bax/caspase 3 anti-apoptotic pathway after ischemic stroke in rats 35 ) .…”
Section: Preconditioning Exercise and Intrinsic Protective Factorsmentioning
confidence: 96%
“…Our previous study demonstrated that preconditioning exercise activates HIF-1α and 14-3-3γ in neurons and astrocytes and subsequently induced neuron-and astrocyte-mediated brain tolerance 35 ) . The upregulated 14-3-3γ induced by precondition-ing exercise reduces ischemic neuronal cell death through the 14-3-3γ/p-β-catenin Ser37/Bax/caspase 3 anti-apoptotic pathway after ischemic stroke in rats 35 ) . Understanding the mode of induction and mechanism of protection for these intrinsic protective factors would be beneficial for administering preconditioning exercise to extend the therapeutic time window, leading to better management of patients with stroke ( Figure 2).…”
Section: Preconditioning Exercise and Intrinsic Protective Factorsmentioning
confidence: 96%
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“…Thus, it is suggested that 14-3-3γ overexpression reactivates Beclin-1-LC3 signaling because of the inhibition of β-catenin in starving neurons ( 43 ). It is also reported that pre-ischemic exercise increases the expression of 14-3-3γ, thereby reducing ischemia-induced neuronal cell death through anti-apoptotic pathways including phosphorylated β-catenin, BAX, and caspase 3 ( 108 ). Therefore, 14-3-3γ is proposed to act as an initial survival factor for ischemic-induced cell death in neurons.…”
Section: -3-3γ In Brain Disordersmentioning
confidence: 99%