Preconditioning exercise reduces hippocampal neuronal damage via increasing Klotho expression in ischemic rats

Cognitive outcomes in patients treated with neuromuscular electrical stimulation after coronary artery bypass grafting

“…We only found that Klotho-responders had significantly lower baseline Klotho values than non-responders (p 0.002), a significantly lower percentage of diabetes (p 0.029) and finally that non-responders were predominantly male (p 0.0385). We performed the same classification (responders/ non-responders) according to the other myokine trend values (data shown in Supplementary material, Results section: Supplementary Tables S2, S3); however, we mainly focused on Klotho, in consideration of the interesting findings reported below, which confirm the well-established neuroprotective role of this myokine (25,26).…”

Research hotspots and frontiers of preconditioning in cerebral ischemia: A bibliometric analysis

“…Ischemic preconditioning increases SOD2 and reduces superoxide anion radical production by increasing the expression of peroxynitrite 2 to exert antioxidant effects, which is abolished by thioredoxin 2 inhibitors [ 96 ]. Preconditioning exercise alleviated neurological dysfunction and cognitive impairment in rats with cerebral ischemia, possibly associated with increased antioxidant capacity of neurons in the hippocampal CA1 region, due to the detection of increased Klotho and MnSOD expression [ 97 ]. Electroacupuncture preconditioning reduced consumption of glutathione (GSH) and glutathione peroxidase-4 (GPX4) to attenuate oxidative stress injury after ischemia/reperfusion [ 98 ].…”

Research progress on molecular mechanisms of general anesthetic-induced neurotoxicity and cognitive impairment in the developing brain

“…When sevoflurane is administered to neonatal rats, organismal stress leads to increased expression of Klotho protein and the mRNA encoding this protein in the hippocampus of neonatal rats, thereby alleviating the neurotoxic effects of sevoflurane in the neonatal brain ( 53 ). It has been shown that Klotho protein activates the transcription of the antioxidant enzyme manganese superoxide dismutase to relieve oxidative stress and reduce hippocampal neuronal injury ( 54 ), and whether this enzyme has a correlation with the PI3K/Akt signaling pathway needs to be further explored. In conclusion, upregulation of Klotho protein expression of this protein is very helpful for alleviating neurotoxicity and cognitive impairment in the newborn brain caused by general anesthetics, and Klotho protein may serve as a research direction for the treatment of general anesthetic-induced neurotoxicity and cognitive impairment in the neonatal brain.…”