2020
DOI: 10.1038/s41434-020-00199-6
|View full text |Cite
|
Sign up to set email alerts
|

Preconditioning of surgical pedicle flaps with DNA plasmid expressing hypoxia-inducible factor-1α (HIF-1α) promotes tissue viability

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
9
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
6

Relationship

2
4

Authors

Journals

citations
Cited by 10 publications
(9 citation statements)
references
References 44 publications
0
9
0
Order By: Relevance
“…[6,7] In recognition of this, many approaches to promote angiogenesis therapeutically have been tried, including delivery of angiogenic genes and proteins using a variety of strategies. [8][9][10] However, clinical translation of such efforts has been limited for a number of reasons, some of which owe to the fact that the complexity of angiogenesis is difficult to control via regulation of a small number of molecular pathways. [11] As a result, new approaches aimed at stimulating angiogenesis more broadly have emerged.…”
Section: Introductionmentioning
confidence: 99%
“…[6,7] In recognition of this, many approaches to promote angiogenesis therapeutically have been tried, including delivery of angiogenic genes and proteins using a variety of strategies. [8][9][10] However, clinical translation of such efforts has been limited for a number of reasons, some of which owe to the fact that the complexity of angiogenesis is difficult to control via regulation of a small number of molecular pathways. [11] As a result, new approaches aimed at stimulating angiogenesis more broadly have emerged.…”
Section: Introductionmentioning
confidence: 99%
“…After abstract screening, 76 articles were eligible for full-text retrieval. Eventually, 51 studies [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ] were included in the qualitative synthesis ( Table 1 ), of which 36 studies with 1576 rats were analyzed quantitatively ( Figure 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…Apart from the studies included in the quantitative analysis, we found several studies with various treatment types used in less than three comparisons. Other substances or combinations containing unidentified molecules were used in 15 studies [ 14 , 15 , 21 , 24 , 25 , 26 , 27 , 35 , 36 , 51 , 52 , 54 , 55 , 56 , 57 ]. The substances or targets previously described include hypoxia-inducible factor, Dikkopf-2, nitric oxide synthase, interleukin-10, angiopoietin, relaxin, NF-κB, KGF, and SDF-1.…”
Section: Resultsmentioning
confidence: 99%
“…This sets the stage for later studies which investigated the efficacy of utilizing a DNA expression plasmid vector to deliver HIF-1α. This approach seeks to avoid the systemic elevation of HIF-1α levels concomitant with DMOG treatment while mitigating the well-known lability of HIF-1α and its angiogenic and pro-proliferative transcription factors 27 , 31 , 45 . Yamamoto et al investigated the RNA-binding protein LIN28A and showed that LIN28A upregulates HIF-1 α expression via mRNA stabilization.…”
Section: Discussionmentioning
confidence: 99%
“…Prior experiences with DNA plasmid delivery demonstrated that a time-limited and localized delivery could potentially be achieved suitable for the clinical applications 29 , 30 . As such, surgical pedicle flap survival in the rat model was improved by pre-treating the flaps with HIF-1α using a DNA expression plasmid vector 31 . However, this approach to HIF-1α delivery involved two serious drawbacks.…”
Section: Introductionmentioning
confidence: 99%