Preconditioning Stem Cells for <i>In Vivo</i> Delivery

Sart, Sébastien; Ma, Teng; Li, Yanyan

doi:10.1089/biores.2014.0012

Cited by 162 publications

(150 citation statements)

References 123 publications

(135 reference statements)

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“…Put simply, are transplanted cells actively undergoing tissue morphogenesis and integration or are they merely mediators, emitting signals to recruit and stimulate their endogenous counterparts into action? The answer might be context-dependent and simple techniques, such as cell aggregation (reviewed elsewhere 130,131 ) might profoundly influence the fate of cells after transplantation. Similarly, continued research into cell–biomaterial interactions (particularly in vivo interactions in immunocompetent animals) that spawn novel techniques for oxygen delivery 132,133 or growth-factor tethering, retention and presentation 111 might profoundly enhance regenerative outcomes.…”

Section: Discussionmentioning

confidence: 99%

Stromal cells and stem cells in clinical bone regeneration

et al. 2015

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Stem-cell-mediated bone repair has been used in clinical trials for the regeneration of large craniomaxillofacial defects, to slow the process of bone degeneration in patients with osteonecrosis of the femoral head and for prophylactic treatment of distal tibial fractures. Successful regenerative outcomes in these investigations have provided a solid foundation for wider use of stromal cells in skeletal repair therapy. However, employing stromal cells to facilitate or enhance bone repair is far from being adopted into clinical practice. Scientific, technical, practical and regulatory obstacles prevent the widespread therapeutic use of stromal cells. Ironically, one of the major challenges lies in the limited understanding of the mechanisms via which transplanted cells mediate regeneration. Animal models have been used to provide insight, but these models largely fail to reproduce the nuances of human diseases and bone defects. Consequently, the development of targeted approaches to optimize cell-mediated outcomes is difficult. In this Review, we highlight the successes and challenges reported in several clinical trials that involved the use of bone-marrow-derived mesenchymal or adipose-tissue-derived stromal cells. We identify several obstacles blocking the mainstream use of stromal cells to enhance skeletal repair and highlight technological innovations or areas in which novel techniques might be particularly fruitful in continuing to advance the field of skeletal regenerative medicine.

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Section: Discussionmentioning

confidence: 99%

Stromal cells and stem cells in clinical bone regeneration

et al. 2015

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“…Hypoxic preconditioning (HP) was performed by exposing cells to non-lethal hypoxia (0.1–1%) for certain hours before transplantation, which is very effective in increasing transplanted cell survival and improving overall functional recovery after stroke or myocardial infarction (MI) (Hu et al , 2011b; Hu et al , 2008; Sun et al , 2015; Theus et al , 2008a; Wei et al , 2012). HP has also shown enhancement of cell differentiation in culture and after transplantation (Sart et al , 2014; Sun et al , 2015). Non-lethal exposure to hypoxic conditions is believed to activate the hypoxia-inducible factor 1α (HIF-1α) pathway, increasing expression of HIF-1α-dependent genes.…”

Section: Strategies To Enhance Cell Survival After Transplantation: Gmentioning

confidence: 99%

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

Wei

Jiang

et al. 2017

Progress in Neurobiology

127

117

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One of the exciting advances in modern medicine and life science is cell-based neurovascular regeneration of damaged brain tissues and repair of neuronal structures. The progress in stem cell biology and creation of adult induced pluripotent stem (iPS) cells has significantly improved basic and pre-clinical research in disease mechanisms and generated enthusiasm for potential applications in the treatment of central nervous system (CNS) diseases including stroke. Endogenous neural stem cells and cultured stem cells are capable of self-renewal and give rise to virtually all types of cells essential for the makeup of neuronal structures. Meanwhile, stem cells and neural progenitor cells are well-known for their potential for trophic support after transplantation into the ischemic brain. Thus, stem cell-based therapies provide an attractive future for protecting and repairing damaged brain tissues after injury and in various disease states. Moreover, basic research on naïve and differentiated stem cells including iPS cells has markedly improved our understanding of cellular and molecular mechanisms of neurological disorders, and provides a platform for the discovery of novel drug targets. The latest advances indicate that combinatorial approaches using cell based therapy with additional treatments such as protective reagents, preconditioning strategies and rehabilitation therapy can significantly improve therapeutic benefits. In this review, we will discuss the characteristics of cell therapy in different ischemic models and the application of stem cells and progenitor cells as regenerative medicine for the treatment of stroke.

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“…However, several challenges remain to be overcome before stem cell therapy can be successfully applied to ischemic stroke treatment. First, the low survival of transplanted stem cells in injured area reduced efficacy of stem cell therapy [48]. Such challenge is faced by stem cell therapy applications in the treatment of other diseases as well.…”

Section: Challenges Of Stem Cell Treatment For Ischemic Strokementioning

confidence: 99%

Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke

Tang

Zhang

et al. 2015

CNS Neurosci Ther

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Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-based therapy is still in its infancy. The next decade of stem cell research in stroke field needs to focus on combining different stem cells and different imaging modalities to fully explore the potential of this therapeutic avenue: from bench to bedside and vice versa.

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Preconditioning Stem Cells for In Vivo Delivery

Cited by 162 publications

References 123 publications

Stromal cells and stem cells in clinical bone regeneration

Stromal cells and stem cells in clinical bone regeneration

Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke

Opportunities and Challenges: Stem Cell‐Based Therapy for the Treatment of Ischemic Stroke

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