1993
DOI: 10.1016/0016-5085(93)90861-6
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Precore mutations and core clustering mutations in chronic hepatitis B virus infection

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Cited by 113 publications
(72 citation statements)
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“…One such mechanism for escape from CTL recognition may involve genetic variation, as demonstrated in HIV, influenza virus, lymphocytic choriomeningitis virus, EBV, and HBV (for review see reference 42). In chronic HBV infection, Chuang et al (43) have reported that there are three mutation clustering regions (MCR) in core gene, codons 48-60 (MCR1), 84-101 (MCR2), and 147-155 (MCR3). MCR2 is the most remarkable, having the highest mutation rates studied in 20 chronic active hepatitis B patients irrespective of their HLA haplotypes (44).…”
Section: Discussionmentioning
confidence: 99%
“…One such mechanism for escape from CTL recognition may involve genetic variation, as demonstrated in HIV, influenza virus, lymphocytic choriomeningitis virus, EBV, and HBV (for review see reference 42). In chronic HBV infection, Chuang et al (43) have reported that there are three mutation clustering regions (MCR) in core gene, codons 48-60 (MCR1), 84-101 (MCR2), and 147-155 (MCR3). MCR2 is the most remarkable, having the highest mutation rates studied in 20 chronic active hepatitis B patients irrespective of their HLA haplotypes (44).…”
Section: Discussionmentioning
confidence: 99%
“…In the literature, out of 65 sequences containing 97L mutations, 10 (15.4%) have concurrent P5T mutations (1,2,5,9,12,13,15,25,27,28). Previously, we reported a compensatory core mutation, P130T, which also can rescue the immature secretion phenotype induced by the I97L mutation (32).…”
mentioning
confidence: 95%
“…Due to the low fidelity of the polymerase, error-prone replication and natural selection in vivo lead to the accumulation of multiple mutations in HBV variants predominant in chronic carriers (20,22). The most frequent natural mutation in the HBV core protein occurs at amino acid 97 (5,6,9,10,13). It remains a challenge to elucidate the functional significance of these prevalent and predominant mutations, since there is no a priori knowledge about what kind of assays should be used.…”
mentioning
confidence: 99%
“…14,15,18,28,29,36). Finally, a very frequent mutation of HBcAg occurs at codon 5, changing a conserved proline (P) to a threonine (T) (1,2,6,11,13,14,18,22,33,38). While the most common mutation found at HBcAg codon 5 is from P to T, other less frequent changes have also been reported, such as proline to serine (S).…”
mentioning
confidence: 99%