Precursor B-cell lymphoblastic lymphoma/leukemia presenting as osteoblastic bone lesions

Cutaneous Precursor B-Cell Lymphoblastic Lymphoma in 2 Adult Patients

“…[10][11][12][16][17][18] Several documented cases are reported in the literature describing B-LBL manifesting as a solitary bone tumor. [19][20][21] Our cases, in addition to those already in the literature, provide additional support for primary cutaneous B-LBL as a clinicopathologic entity. In our review of the literature (Table 1), there were 13 cases of B-LBL with only skin involvement at the time of presentation.…”

Primary lumbar spinal epidural b-lymphoblastic lymphoma: A case report

“…By Liu/Wang/Ren/Zhong/Li/Qu convention, the word "lymphoma" is used if there is a bulky lesion in the mediastinum or elsewhere, with no or minimal evidence of peripheral blood and bone marrow involvement. In general, a threshold of <25% bone marrow blasts is used for defining lymphoma [8]. Because blood counts and bone marrow biopsy were negative in our patient, a diagnosis of primary spinal epidural B-LBL was made.…”

Pediatric precursor B-cell lymphoblastic lymphoma presenting with extensive skeletal lesions

“…Other sites included the humerus, vertebrae, scapula, foot and rib. [4] Our patient had multiple osteolytic lesions in the femur, tibia, pelvis and vertebrae. Parathormone-related protein (PTHrP) produced by lymphoblast is a possible factor causing multiple osteolytic lesions and hypercalcemia in these patients.…”

“…[3] Bony lesions in pre-B LL are usually osteolytic, although few cases with osteoblastic lesions have been reported. [4] The most frequent osseous sites are the femur, followed by the tibia. Other sites included the humerus, vertebrae, scapula, foot and rib.…”