Precursor lesions in familial and hereditary pancreatic cancer

Pflüger, Michael J.; Brosens, Lodewijk A.A.; Hruban, Ralph H.

doi:10.1007/s10689-024-00359-2

Cited by 1 publication

(1 citation statement)

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“…Precursor lesions of pancreatic cancer are important as they represent potential targets for cancer prevention. Pflüger, Brosens and Hruban [ 44 ] provide comprehensive insights into the characteristics of various precursor lesions associated with pancreatic cancer development. They also present current data on the prevalence and features of these lesions in individuals at risk for familial pancreatic cancer, as well as in carriers of various pathogenic germline variants linked to pancreatic cancer.…”

Section: Content and Aim Of Special Issuementioning

confidence: 99%

Twenty-five years of surveillance for familial and hereditary pancreatic ductal adenocarcinoma: Historical perspectives and introduction to the special issue

Vasen,

Canto,

Goggins

2024

Familial Cancer

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In the 1990s, as prevention became a central strategy in the battle against cancer and the molecular genetics revolution uncovered the genetic basis of numerous hereditary cancer syndromes, there were no options available for patients at increased risk of developing pancreatic cancer. When surveillance efforts for those at familial and hereditary risk of pancreatic cancer emerged in the late 1990s, it was uncertain if early detection was achievable.In this introduction to the special issue, we offer an overview of the history of surveillance for pancreatic cancer, including the first reports of familial pancreatic cancer in the medical literature, the initial results of surveillance in the United States and the initiation of surveillance programs for hereditary pancreatic cancer in the Netherlands.This special issue features a collection of 18 articles written by prominent experts in the field, focusing specifically on refining surveillance methodologies with the primary objective of improving care of high-risk individuals. Several reviews in this collection highlight improved survival rates associated with pancreas surveillance, underlying the potential of early detection and improved management in the continuing fight against pancreatic cancer.

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Section: Content and Aim Of Special Issuementioning

confidence: 99%