Precursor Lesions of Oesophageal Cancer in High-Risk Populations in Iran and China

Muñóz, Núbia; Grassi, Antonio; Shen, Qiong; Crespi, Massimo; Qing, Wang Guo; Cai, Li Zhang

doi:10.1016/s0140-6736(82)92151-1

Cited by 131 publications

(54 citation statements)

References 10 publications

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“…These data, however, do not show whether the effect is due to vitamin A itself or carotenoids. The evidence from both animal experiments (Wynder and Klein, 1965;Foy and Kondi, 1984) and human studies (Thurnham et al, 1982;Crespi et al, 1979;Munoz et al, 1982) indicates a possible association between riboflavin deficiency and oesophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Kolicheva (1970) and Kolicheva et al (1970) reported high prevalences (88 % and 66%) of chronic oesophagitis in 2 areas with a high incidence of oesophageal cancer in Kazakhstan in a series of autopsies of people who had died from causes other than oesophageal cancer, and described the endoscopic and histological picture of this condition. Chronic oesophagitis was discovered in 85 % and 66% of the population in North Iran and North China, respectively, during an endoscopic survey in areas with a high incidence of oesophageal cancer (Crespi et al, 1979;Munoz et al, 1982).…”

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confidence: 99%

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Survey of a population with a high incidence of oral and oesophageal cancer

Заридзе

Blettner

Trapeznikov

et al. 1985

Intl Journal of Cancer

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The results of a survey of a population with a high incidence of oral and oesophageal cancer are presented. The population under study appears to have several epidemiologic characteristics, some of which may be associated with a high incidence of oral and oesophageal cancer. A remarkably high proportion (41%) of the men surveyed were nass users and this habit, like the use of other types of tobacco mixtures, has been related to oral cancer. Oral leukoplakia and chronic oesophagitis (conditions thought to be precursors of oral and oesophageal cancer) have been diagnosed in 11% and 60%, respectively, of the persons examined. Analysis of the relationship between nass use, cigarette smoking, oral leukoplakia and oesophagitis revealed that the prevalence of oral leukoplakia is highest among cigarette smokers who use nass. It appears that nass use does not affect the frequency of occurrence of chronic oesophagitis. However, a slight elevation of the prevalence odds ratio was observed for current smokers and drinkers. Biochemical analysis of the blood of a random sample of the surveyed population revealed low levels of riboflavin, vitamin A and carotenoids--vitamins that most probably have a protective effect against the development of cancer. The mutagenicity test has shown that nass contains a chemical or chemicals that exert a genotoxic effect. Chemical analysis revealed the presence in nass of tobacco-specific N-nitroso compounds.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Survey of a population with a high incidence of oral and oesophageal cancer

Заридзе

Blettner

Trapeznikov

et al. 1985

Intl Journal of Cancer

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“…By our definition, acanthosis was uncommon but not rare. Crespi's finding that 77% of patients in this population showed clear cell acanth~sis"-'~ must have relied on a significantly different division point to separate thick from normal biopsies and/or must have based this Crespi et al [10][11][12][13] do not mention basaI cell hyperplasia as a criterion for esophagitis. Qiu et al,'*,15 requiring that the basal zone be greater than 50% of epithelial thickness to diagnose basal cell hyperplasia, identified this finding in 31% of patients from Linxian and 74% of patients from Huixian, prevalences that are much greater than what we found in our biopsies.…”

Section: Comparisons W I T H Previous Studiesmentioning

confidence: 99%

Esophageal morphology from Linxian, China. Squamous histologic findings in 754 patients

Dawsey

Lewin²,

Liu

et al. 1994

Cancer

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Background. Linxian, China, has one of the highest rates of esophageal cancer in the world. Other authors have described high prevalences of histologic esophagitis, atrophy, and dysplasia in Linxian and have suggested that these findings may represent precancerous lesions in this population. In 1987, a new endoscopic survey allowed the authors to make an independent study of esophageal histology in Linxian. Methods. There were 1567 satisfactory squamous esophageal biopsies available from 754 patients. These biopsies were classified as normal, atrophy, acanthosis, esophagitis, squamous dysplasia, or squamous cancer. Results. Classified by their worst diagnosis, 56.5% of the 754 patients had normal mucosa, 0.0% atrophy, 11.5% acanthosis, 4.6% esophagitis, 22.7% squamous dysplasia, and 4.6% squamous cancer. Conclusions. The results show a different distribution of esophageal squamous diagnoses than has been reported previously from this population. The authors believe that the major reason for this discrepancy was differences in histologic criteria. In this survey, seemingly small differences in criteria could cause large differences in apparent disease prevalence; this was especially true for esophagitis. By the criteria used in this study, histologic esophagitis and atrophy are uncommon findings in Linxian, raising questions about their significance as precursor lesions of esophageal cancer in this population.

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“…Epidemiologic studies have revealed that environmental factors, such as tobacco smoking, heavy alcohol drinking, and micronutrient deficiency, are linked to the etiology of this malignancy (2). In addition, chronic inflammation, which has been associated with carcinogenesis in various tissue sites, might also contribute to the risk of developing ESCC (3,4). However, only a portion of individuals develop ESCC, suggesting that individual genetic makeup may play a role in esophageal carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Functional Role of S100A14 Genetic Variants and Their Association with Esophageal Squamous Cell Carcinoma

Chen

Luo

et al. 2009

Cancer Research

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S100 proteins have been implicated in various human diseases, including certain types of cancer. Among them, S100A14 is down-regulated in esophageal squamous cell carcinoma (ESCC). In this study, we sought to identify functional genetic variants in the S100A14 locus and assessed their associations with susceptibility to ESCC. Thirty individual DNA samples were sequenced to search for genetic variations in S100A14, and the function of the variants was investigated by a set of biochemical assays. A case-control analysis was performed in 1,021 patients with ESCC and 1,253 control subjects. Odds ratios and 95% confidence intervals (95% CI) were computed by logistic regression model. Four single nucleotide polymorphisms, À43A>G, 461G>A, 1493A>G, and 1545A>T, were identified in the S100A14 locus and they are in absolute linkage disequilibrium. Among them, the 461G>A change was shown to diminish a P53-binding site and is therefore associated with decreased expression of S100A14 in vitro and in vivo in the target tissues. Case-control analysis showed that the 461A allele was associated with susceptibility to ESCC among smokers, with the ORs being 2.01 (95% CI, 1.50-2.69) or 2.10 (95% CI, 1.37-3.22) for the 461GA or 461AA genotype, respectively, compared with the 461GG genotype. These data constitute strong evidence in support of the notion that S100A14 might function as a cancer suppressor working in the P53 pathway and play a role in esophageal carcinogenesis. [Cancer Res 2009;69(8):3451-7]

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Precursor Lesions of Oesophageal Cancer in High-Risk Populations in Iran and China

Cited by 131 publications

References 10 publications

Survey of a population with a high incidence of oral and oesophageal cancer

Survey of a population with a high incidence of oral and oesophageal cancer

Esophageal morphology from Linxian, China. Squamous histologic findings in 754 patients

Functional Role of S100A14 Genetic Variants and Their Association with Esophageal Squamous Cell Carcinoma

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