Predator odor-induced conditioned fear involves the basolateral and medial amygdala.

Takahashi, Lorey K.; Hubbard, David; Lee, Iris; Dar, Yasmin; Sipes, Sara M.

doi:10.1037/0735-7044.121.1.100

Cited by 81 publications

(75 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These differences were indicative of a trend analogous to group differences in locomotor activity in the novel SI arena. Given an a priori hypothesis of impaired stimulus-induced fear responding associated with amygdala lesions (Kalin, Shelton, & Davidson, 2004;Takahashi, Hubbard, Lee, Dar, & Sipes, 2007), one-tailed t testing revealed significant group differences, t(47) = −1.7, p < .05. …”

mentioning

confidence: 99%

Neonatal amygdala lesions: Co-occuring impact on social/fear-related behavior and cocaine sensitization in adult rats.

Chambers

Sajdyk

Conroy

et al. 2007

Behavioral Neuroscience

View full text Add to dashboard Cite

Neurodevelopmental abnormalities of temporal-limbic structures may underlie both adult psychiatric syndromes and increased addiction vulnerability, leading to high frequencies of "dual diagnosis" disorders. Although the amygdala is implicated in various mental disorders and drug addiction, no studies have explored the impact of early developmental damage to the amygdala on phenotypes relating to mental illness and addictions as co-occurring processes. We tested rats with neonatal amygdala lesions (NAML) vs. SHAM-operated controls in a battery of tests-novel field activity, elevated plus maze (EPM), and social interaction (SI) at baseline and after odor and restraint stress-followed by measures of cocaine sensitization (15 mg/kg vs. saline × 5 days + challenge session 2 weeks later) and remeasurement of SI. NAMLs showed increased novelty-related locomotion, less fear responding in the EPM, and resistance to predator-odor-but not to restraintinduced suppression of SI. NAMLs also had elevated cocaine sensitization profiles, and cocaine history differentially affected subsequent SI in NAMLs compared with SHAMs. NAMLs may provide models for understanding a shared neurobiological basis for and complex interactions among psychiatric symptoms, drug exposure history, and addiction vulnerability. Keywords amygdala; cocaine; neurodevelopment; dual diagnosis; social interaction Substance use disorder comorbidity in mental illness spans differential psychiatric diagnoses and drugs of abuse (Kessler, 2004;Regier et al., 1990). In many treatment settings, these "dual diagnosis" presentations are the majority of cases, associated with increased medical and psychiatric morbidity and mortality, financial destitution, and criminal incarceration (Dickey, Normand, Weiss, Drake, & Azeni, 2002;Dixon, 1999;RachBeisel, Scott, & Dixon, 1999). Emerging clinical and basic research suggests that varieties of mental illness and the addiction process involve integrated neurocircuits leading to increased addiction vulnerability regardless of or despite psychoactive consequences of drug use (Chambers, Krystal, & Self, 2001;Volkow, 2004). Functional and/or developmental abnormalities of the hippocampal formation and other temporal-limbic circuits are associated with a range of major neuropsychiatric and personality disorders that are frequently dually diagnosed (Blumberg et al., 2003;Bremner et al., 2000Bremner et al., , 1995Driessen et al., 2000;Weinberger, 1999). Meanwhile, these temporal-limbic regions are also directly connected with and modulate functional and neuroadaptative processes of frontal cortical-striatal motivational circuits impacted by addictive drugs (Chambers et al., Correspondence concerning this article should be addressed to R. Andrew Chambers, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202. robchamb@iupui.edu. NIH Public Access Author ManuscriptBehav Neurosci. Author manuscript; available in PMC 2010 July 2. 2001;Goto & O'Donnell, 2004;Kelley & Domesick, 1982;O'Donnell, Lewis, Weinbe...

show abstract

mentioning

confidence: 99%

Neonatal amygdala lesions: Co-occuring impact on social/fear-related behavior and cocaine sensitization in adult rats.

Chambers

Sajdyk

Conroy

et al. 2007

Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

“…Coffee odor, which is associated with neither preference nor aversion [49], produced defensive behavior in rats when they were reexposed to the conditioned odor alone, but only after five session of pairing the odor with footshock [50]. Additionally, the use of a predator odor instead of footshock has been an important tool to establish contextual conditioned stimulus associations in the brain [51,52].…”

Section: Discussionmentioning

confidence: 99%

Exposure to an Alarm Pheromone Combined with Footshock Stress Enhances Responsivity of the Medial Amygdala-Hippocampus Circuit

Contreras¹

2014

AJPN

View full text Add to dashboard Cite

Alarm substances are released under stressful situations and may constitute signals that prevent other members of the group from encountering dangerous situations by producing fear. 2-Heptanone is an alarm pheromone that increases the neuronal firing rate in temporal lobe structures that are related to fear in the rat, such as the basal amygdala. A single stress session of unavoidable electric footshock or 2-heptanone sniffing increases the responsivity of the medial amygdala-hippocampus circuit, but unknown is the timing of action of simultaneous exposure to both stressors on the firing rate and responsivity of CA1-CA3 neurons identified by their connections with the medial amygdala nucleus. Twenty-four or 48 h after a single stress session, we obtained single-unit extracellular recordings. The firing rate was higher in the 48 h group. The peristimulus histogram showed an increase in the responsivity of amygdala-hippocampus neurons, which was more pronounced 48 h after a single stress session. The present results suggest an increase in the sensitivity of this circuit after a single stress session, seemingly representing a first step in the formation of emotional memories related to a conditioned response to fear.

show abstract

“…This seems to be the case since medial amygdala is involved in the neuronal circuit associated to memory formation related to odors coming from predators leading further to the expression of unconditioned and conditioned fear behavior elicited by these odors. 12,22 In conclusion, a single exposure to 2-heptanone elicits an increase in the medial amygdala-hippocampus connection responsivity. This could represent the formation of memories related with fear.…”

Section: Discussionmentioning

confidence: 99%

“…19 This substance is delivered by urine, and its concentration increases in animals physically stressed and a single exposure to 2-heptanone causes signs of anxiety in conspecifics in the short term and despair in the long-term. 20,21 Some odors can elicit unconditioned and conditioned fear behavior, 22,23 depending on context. But any response involving fear must affect the neuronal activity of amygdaline and hippocampal structures.…”

Section: Introductionmentioning

confidence: 99%

An alarm pheromone increases the responsivity of amygdaline-hippocampal Neurons - Una feromona de alarma incrementa la responsividad de neuronas amigdalino-hipocampales

2013

View full text Add to dashboard Cite

SUMMARYThe capability to perceive and emit alarm substances, such as 2-heptanone, makes animals aware of the presence of danger, leading to some strategies directed towards survival. Strategies of survival involve emotional memory which is processed by deep temporal lobe structures, such as amygdaloid complex and hippocampus. In the Wistar rat, 2-heptanone produces anxiety-like behavior and an increased firing rate of basal amygdaline neurons. However, it is unknown whether 2-heptanone modifies the responsivity of medial amygdalinehippocampal connection. Therefore, we placed a group (n=10) of Wistar rats in a plexiglass cage impregnated with 2-heptanone. Rats from control group (n=10) were introduced into a similar clean cage. Twenty four hours later we obtained single-unit extracellular recordings from the hippocampus (CA1-CA3) neurons identified by their connection to medial amygdala. Although the basal neuronal firing rate was similar between groups, first order interval distribution histogram analysis showed that 2-heptanone produced shorter intervals of firing rate. Peristimulus histograms indicated that: i) the amygdaline stimulation produces an increased firing rate in hippocampal neurons; and ii) this response is increased and enlarged on the 2-heptanone group. Since a single exposure to an alarm pheromone seems to facilitate the amygdala-hippocampal connection, results suggest the initial formation of contextual memories related with fear.Key words: 2-heptanone, medial amygdala, hippocampus, alarm pheromone, anxiety, emotional memory. RESUMENLa percepción olfatoria de feromonas de alarma, como la 2-heptanona, promueve ciertas estrategias de supervivencia con la participación de la memoria emocional, integrada en estructuras del lóbulo temporal, como la amígdala y el hipocampo. En la rata Wistar, la olfacción de 2-heptanona genera conductas sugerentes de ansiedad y un incremento de la tasa de disparo neuronal del núcleo basal de la amígdala. Sin embargo, no se conoce si la 2-heptanona modifica la responsividad de la conexión amígdala medial-hipocampo. Un grupo de ratas Wistar (n=10) fue colocado dentro de una caja de acrílico impregnada con 2-heptanona; el grupo control (n=10) fue introducido en una caja limpia. Veinticuatro horas después se obtuvo el registro unitario extracelular de neuronas del hipocampo (CA1-CA3) identificadas por su conexión con la amígdala medial. Aunque la tasa de disparo basal fue similar entre los grupos experimentales, el histograma de distribución de intervalos de primer orden indicó un predominio de intervalos de breve duración en el grupo 2-heptanona. Los histogramas periestímulo indicaron que: i) las neuronas hipocampales responden con un incremento en la tasa de disparo neuronal ante la estimulación amigdalina; ii) la respuesta es de mayor magnitud y duración en el grupo previamente expuesto a 2-heptanona. Dado que una sola exposición a una feromona de alarma facilita la conexión amígdala medial-hipocampo, los resultados sugieren la formación inicial de una memoria context...

show abstract

Predator odor-induced conditioned fear involves the basolateral and medial amygdala.

Cited by 81 publications

References 36 publications

Neonatal amygdala lesions: Co-occuring impact on social/fear-related behavior and cocaine sensitization in adult rats.

Neonatal amygdala lesions: Co-occuring impact on social/fear-related behavior and cocaine sensitization in adult rats.

Exposure to an Alarm Pheromone Combined with Footshock Stress Enhances Responsivity of the Medial Amygdala-Hippocampus Circuit

An alarm pheromone increases the responsivity of amygdaline-hippocampal Neurons - Una feromona de alarma incrementa la responsividad de neuronas amigdalino-hipocampales

Contact Info

Product

Resources

About