Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons

Curtis, Andre L.; Leiser, Steven C.; Snyder, Kevin M.; Valentino, Rita J.

doi:10.1016/j.neuropharm.2011.11.020

Cited by 101 publications

(119 citation statements)

References 46 publications

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“…This post-stress inhibition serves to promote recovery of LC activity after stressor termination and protect against sustained hyperactivity (Curtis et al, 2001). Opioid afferents to the LC and occupation of μ-opioid receptors have been implicated in this inhibition (Curtis et al, 2001(Curtis et al, , 2012. The current findings indicate that the suppression of LC activity in adult rats exposed to repeated social stress is ongoing by the fifth day of social stress.…”

Section: Repeated Social Stress and Basal Lc Activitysupporting

confidence: 52%

“…Like other stressors, acute social stress shifted the mode of LC activity toward a high tonic state characterized by increased spontaneous discharge rate and diminished responses to discrete sensory stimuli (Curtis et al, 2001(Curtis et al, , 2012. Additionally, acute social stress altered LC network activity, inducing prominent theta oscillations within the LC and increasing LC-mPFC coherence within the theta range.…”

Section: Discussionmentioning

confidence: 99%

“…Surgery for LC implantation of an 8-microwire electrode array (NB Labs, Denison, TX) was identical to that previously described (Curtis et al, 2012). The array was attached to a Microstar head stage connected to a data acquisition system (AlphaLab; Alpha Omega; Nazareth Illi, Israel).…”

Section: Surgerymentioning

confidence: 99%

“…Single unit LC waveforms were discriminated and sorted using the WaveMark template-matching algorithm in Spike2 (Supplementary Figures S1A and B) (Cambridge Electronic Design, CED, v7.09), as described previously (Curtis et al, 2012). Determination of single LC neuron waveform templates was made using baseline activity.…”

Section: Electrophysiological Analysismentioning

confidence: 99%

“…This activation is mediated by corticotropin-releasing factor (CRF), which enhances arousal and cognitive flexibility Valentino and Van Bockstaele, 2008). Acute stress also engages an opioid receptor-mediated inhibition that restrains the excitation and facilitates the recovery of LC activity after stressor termination (Curtis et al, 2001(Curtis et al, , 2012. Repeated resident-intruder exposure produces enduring changes in afferent regulation of the LC that are expressed days after the last stress.…”

Section: Introductionmentioning

confidence: 99%

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Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Zitnik

Curtis

Wood

et al. 2015

Neuropsychopharmacol

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Early life stress is associated with the development of psychiatric disorders. Because the locus coeruleus-norepinephrine (LC-NE) system is a major stress-response system that is implicated in psychopathology, developmental differences in the response of this system to stress may contribute to increased vulnerability. Here LC single unit and network activity were compared between adult and adolescent rats during resident-intruder stress. In some rats, LC and medial prefrontal cortex (mPFC) coherence was quantified. The initial stress tonically activated LC neurons and induced theta oscillations, while simultaneously decreasing LC auditory-evoked responses in both age groups. Stress increased LC-mPFC coherence within the theta range. With repeated exposures, adolescent LC neuronal and network activity remained elevated even in the absence of the stressor and were unresponsive to stressor presentation. In contrast, LC neurons of adult rats exposed to repeated social stress were relatively inhibited in the absence of the stressor and mounted robust responses upon stressor presentation. LC sensory-evoked responses were selectively blunted in adolescent rats exposed to repeated social stress. Finally, repeated stress decreased LC-mPFC coherence in the high frequency range (beta and gamma) while maintaining strong coherence in the theta range, selectively in adolescents. Together, these results suggest that adaptive mechanisms that promote stress recovery and maintain basal activity of the brain norepinephrine system in the absence of stress are not fully developed or are vulnerable stress-induced impairments in adolescence. The resulting sustained activation of the LC-NE system after repeated social stress may adversely impact cognition and future social behavior of adolescents.

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Section: Repeated Social Stress and Basal Lc Activitysupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Surgerymentioning

confidence: 99%

Section: Electrophysiological Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Zitnik

Curtis

Wood

et al. 2015

Neuropsychopharmacol

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Central Nervous System Control of Gastrointestinal Motility and Secretion and Modulation of Gastrointestinal Functions

Browning

Travagli

2014

Comprehensive Physiology

445

388

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Although the gastrointestinal (GI) tract possesses intrinsic neural plexuses that allow a significant degree of autonomy over GI functions, the central nervous system (CNS) provides extrinsic neural inputs that regulate, modulate, and control these functions. While the intestines are capable of functioning in the absence of extrinsic inputs, the stomach and esophagus are much more dependent upon extrinsic neural inputs, particularly from parasympathetic and sympathetic pathways. The sympathetic nervous system exerts a predominantly inhibitory effect upon GI muscle and provides a tonic inhibitory influence over mucosal secretion while, at the same time, regulates GI blood flow via neurally mediated vasoconstriction. The parasympathetic nervous system, in contrast, exerts both excitatory and inhibitory control over gastric and intestinal tone and motility. Although GI functions are controlled by the autonomic nervous system and occur, by and large, independently of conscious perception, it is clear that the higher CNS centers influence homeostatic control as well as cognitive and behavioral functions. This review will describe the basic neural circuitry of extrinsic inputs to the GI tract as well as the major CNS nuclei that innervate and modulate the activity of these pathways. The role of CNS-centered reflexes in the regulation of GI functions will be discussed as will modulation of these reflexes under both physiological and pathophysiological conditions. Finally, future directions within the field will be discussed in terms of important questions that remain to be resolved and advances in technology that may help provide these answers.

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Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD

2014

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Post-traumatic stress disorder (PTSD) is characterized by intrusive memories of a traumatic event, avoidance behavior related to cues of the trauma, emotional numbing, and hyper-arousal. Sleep abnormalities and nightmares are core symptoms of this disorder. In this review, we propose a model which implicates abnormal activity in the locus coeruleus (LC), an important modifier of sleep-wake regulation, as the source of sleep abnormalities and memory abnormalities seen in PTSD. Abnormal LC activity may be playing a key role in symptom formation in PTSD via sleep dysregulation and suppression of hippocampal bidirectional plasticity.

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Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons

Cited by 101 publications

References 46 publications

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Adolescent Social Stress Produces an Enduring Activation of the Rat Locus Coeruleus and Alters its Coherence with the Prefrontal Cortex

Central Nervous System Control of Gastrointestinal Motility and Secretion and Modulation of Gastrointestinal Functions

Trauma exposure and sleep: using a rodent model to understand sleep function in PTSD

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