Prediabetes

Edwards, Catherine; Cusi, Kenneth

doi:10.1016/j.ecl.2016.06.007

Cited by 66 publications

(35 citation statements)

References 83 publications

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“…insulin resistance and pancreatic beta cell dysfunction [38][39][40]. Pre-diabetes is linked to a greater risk of developing diabetes and is also associated with a higher risk of cardiovascular disease, CKD, and ocular abnormalities [41][42][43][44][45].…”

Section: Competing Interestsmentioning

confidence: 99%

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

et al. 2020

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To determine the association between known risk factors (e.g., obesity, metabolic syndrome and its components) and the development of pre-diabetes or diabetes over time in a cohort of Mexican health workers. Methods Participants in the Mexican Health Worker Cohort Study with complete information at two waves of data collection, 2004-2006 (W1) and 2011-2013 (W2), were included in the analysis (n = 1,174). Multivariable binary and multinomial logistic regression were used to examine the cross-sectional associations between specific risk factors and diabetes status (diabetes, pre-diabetes, or neither) at W1 and the longitudinal associations between changes in risk factors and progression of diabetes status from W1 to W2, respectively. Results Mean time between waves was 7.0 years (SD 1.1). Prevalence of pre-diabetes and diabetes was 16% and 10% at W1 and increased to 30% and 16% at W2, respectively. The crosssectional prevalence of pre-diabetes and diabetes was significantly higher among men, participants over the age of 45 years, and individuals who were overweight or obese or had metabolic syndrome (MS), three or more components of the MS, elevated alanine aminotransferase (ALT) levels, or elevated uric acid. In longitudinal analyses, remaining obese or gaining weight between waves was associated with an increased risk of developing pre-diabetes. A greater risk of developing pre-diabetes or diabetes was also observed among

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Section: Competing Interestsmentioning

confidence: 99%

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

et al. 2020

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“…In prediabetes and T2DM, reduced insulin-stimulated glucose uptake by skeletal muscle is a current feature [3, 41]. Additionally, in T1DM, skeletal muscle glucose disposal can also be reduced because of glucotoxicity and/or hyperinsulinemia [42], pointing out that insulin therapy is obligatory.…”

Section: Skeletal Muscle Glut4 Expression and Translocation: From mentioning

confidence: 99%

MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance

Esteves

Enguita

Machado

2017

Journal of Diabetes Research

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The solute carrier family 2 facilitated glucose transporter member 4 (GLUT4) plays a key role in the insulin-induced glucose uptake by muscle and adipose tissues. In prediabetes and diabetes, GLUT4 expression/translocation has been detected as reduced, participating in mechanisms that impair glycemic control. Recently, a class of short endogenous noncoding RNAs named microRNAs (miRNAs) has been increasingly described as involved in the posttranscriptional epigenetic regulation of gene expression. The present review focuses on miRNAs potentially involved in the expression of GLUT4 expression, and proteins related to GLUT4 and translocation in skeletal muscle, seeking to correlate them with insulin resistance and diabetes. So far, miR-21a-5p, miR-29a-3p, miR-29c-3p, miR-93-5p, miR-106b-5p, miR-133a-3p, miR-133b-3p, miR-222-3p, and miR-223-3p have been reported to directly and/or indirectly regulate the GLUT4 expression; and their expression is altered under diabetes-related conditions. Besides, some miRNAs that have been linked to the expression of proteins involved in GLUT4 translocation machinery in muscle could also impact glucose uptake. That makes these miRNAs promising targets for preventive and/or therapeutic approaches, which could improve glycemic control, thus deserving future new investigations.

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“…Most of our study subjects were overweight or obese, and there was a trend toward an increased body mass index in comparison to the subjects with increased HbA1c, which is compa-tible with the findings of a previous study ( 28 ). Insulin resistance, which exists in most overweight or obese individuals, plays a significant role in prediabetes; therefore, it is reasonable to assume that these conditions can occur concomitantly ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the longitudinal deformation of the left ventricular myocardium in subjects with impaired fasting glucose with and without increased glycated hemoglobin

Akhavan-Khaleghi¹,

Hosseinsabet

2018

Anatol J Cardiol

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ObjectivePrediabetes comprises a heterogeneous group because of the poor concordance of its definition. The aim of our study was to evaluate the longitudinal deformation of the left ventricular (LV) myocardium at the two opposite ends of the prediabetes spectrum as defined by fasting blood sugar and glycated hemoglobin (HbA1c).MethodsEighty consecutive subjects in a cross-sectional single-center study with impaired fasting glucose (IFG) (100–126 mg/dL) and without significant epicardial coronary artery stenosis seen on selective coronary angiography were included in our study and were divided into two groups based on their HbA1c levels (<5.7% and 5.7%–6.4%). The longitudinal deformation of the LV myocardium was compared between the two groups using two-dimensional speckle-tracking echocardiography (2DSTE).ResultsThe Student t-test, Mann–Whitney U test, or X2 test was used for data analysis, whichever was appropriate. The systolic strain (–16.1%±2.0 vs. –16.8%±2.4; p=0.214), systolic strain rate (–1.3±0.2 s–1 vs. –1.4±0.2 s–1; p=0.403), and early and late-diastolic strain rates (1.4±0.3 s–1 vs. 1.5±0.3 s–1; p=0.456 and 0.9±0.1 s–1 vs. 1.0±0.2 s–1; p=0.684, respectively) of the LV myocardium were not statistically different between the IFG subjects with and without increased HbA1c as detected using 2DSTE.ConclusionThe longitudinal deformation of the LV myocardium as detected using 2DSTE in the subjects without significant epicardial coronary artery stenosis was not statistically significantly different between the IFG subjects with and without increased HbA1c.

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Prediabetes

Cited by 66 publications

References 83 publications

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers

MicroRNAs-Mediated Regulation of Skeletal Muscle GLUT4 Expression and Translocation in Insulin Resistance

Evaluation of the longitudinal deformation of the left ventricular myocardium in subjects with impaired fasting glucose with and without increased glycated hemoglobin

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