Prediabetes and Risk of Glomerular Hyperfiltration and Albuminuria in the General Nondiabetic Population: A Prospective Cohort Study

Prevalence of Prediabetes and the Associated Risk of Kidney Disease in Apparently Healthy Subjects in Nnewi, Anambra State, Nigeria

“…Researchers discovered that fasting glucose levels consistent with prediabetes are independent risk factors for hyperfiltration in the kidneys and the presence of albumin in the urine which are all indicators of kidney disease. They also show that the pathological process of kidney injury caused by elevated blood glucose levels starts in prediabetes ,well before the onset of diabetes [7]. There are many causes of kidney failure which include high blood pressure, glomerulonephritis, urologic diseases, or cystic disease.…”

“…The authors conclude that prediabetes is increasing in prevalence and that demographic subgroups may benefit from targeted diabetes prevention efforts. Research study suggests that high levels of glucose could be affecting kidneys even prior to diabetes diagnoses [7]. Kidney failure is a serious condition when kidneys fail to eliminate the body's waste and is the final stage of chronic kidney failure.…”

“…There are many causes of kidney failure which include high blood pressure, glomerulonephritis, urologic diseases, or cystic disease. Among those causes, diabetes is the most common cause of kidney failure accounting for almost 44% of new patient cases, Even with tight controls over blood glucose, patients with diabetes can still progress to kidney failure [7]. However, recent research shows that for the kidneys problems may begin to occur in prediabetic stage, long before a patient is actually diagnosed with diabetes.…”

“…However, recent research shows that for the kidneys problems may begin to occur in prediabetic stage, long before a patient is actually diagnosed with diabetes. The study conducted at the university hospital of North Norway in Toronto, found that evidence of kidney damage that is typically associated with diabetes actually starts when blood sugar levels are consistent with prediabetes [7]. Screening for albuminuria and measurement of serum creatinine, urea and Electrolytes are currently recommended by the American Diabetes Association for the diagnoses of either diabetes or prediabetes and annually thereafter (standard of medical care in diabetes,2009).…”

“…For, et al [11] from the Framingham Heart study observed a stronger association between other cardiovascular risk factors and CKD observed in patients with prediabetes is due to macrovascular disease, especially hypertension and not in microvascular disease. Recent studies also showed that prediabetes is the leading cause of kidney failure accounting for 44% of new cases of kidney failure [7]. Some data indicated that lifestyle interventions for prediabetes can return individuals for normoglyceamia Perreault, et al [12] and Schellenberg and Dryden [13].…”