Prediabetes and working memory in older adults

Ennis, Gilda E.; Saelzler, Ursula G.; Umpiérrez, Guillermo E.; Moffat, Scott D.

doi:10.1177/2398212820961725

Cited by 18 publications

(12 citation statements)

References 58 publications

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“…Specifically in the brain, these conditions can cause neuronal pathology, alterations in synaptic communication as well as amyloid and tau pathologies [ 13 , 14 ]. Moreover, diabetes and even prediabetes impair memory processing [ 15 ]. Whereas all these data support common links between AD and metabolic disorders, to our knowledge the impact of prediabetes and overt T2D on vascular function, oxidative stress or MMP alterations associated with amyloid pathology in AD remains largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes

Vargas-Soria

Ramos-Rodríguez

Marco

et al. 2022

Fluids Barriers CNS

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Background While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have described a close relationship between AD and T2D with clinical evidence showing that both diseases coexist. A hallmark pathological event in AD is amyloid-β (Aβ) deposition in the brain as either amyloid plaques or around leptomeningeal and cortical arterioles, thus constituting cerebral amyloid angiopathy (CAA). CAA is observed in 85–95% of autopsy cases with AD and it contributes to AD pathology by limiting perivascular drainage of Aβ. Methods To further explore these alterations when AD and T2D coexist, we have used in vivo multiphoton microscopy to analyze over time the Aβ deposition in the form of plaques and CAA in a relevant model of AD (APPswe/PS1dE9) combined with T2D (db/db). We have simultaneously assessed the effects of high-fat diet-induced prediabetes in AD mice. Since both plaques and CAA are implicated in oxidative-stress mediated vascular damage in the brain, as well as in the activation of matrix metalloproteinases (MMP), we have also analyzed oxidative stress by Amplex Red oxidation, MMP activity by DQ™ Gelatin, and vascular functionality. Results We found that prediabetes accelerates amyloid plaque and CAA deposition, suggesting that initial metabolic alterations may directly affect AD pathology. T2D significantly affects vascular pathology and CAA deposition, which is increased in AD-T2D mice, suggesting that T2D favors vascular accumulation of Aβ. Moreover, T2D synergistically contributes to increase CAA mediated oxidative stress and MMP activation, affecting red blood cell velocity. Conclusions Our data support the cross-talk between metabolic disease and Aβ deposition that affects vascular integrity, ultimately contributing to AD pathology and related functional changes in the brain microvasculature.

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Section: Introductionmentioning

confidence: 99%

Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes

Vargas-Soria

Ramos-Rodríguez

Marco

et al. 2022

Fluids Barriers CNS

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“…At present, much evidence shows that patients with diabetes can suffer cognitive and memory impairment [40]. The rate of cognitive dysfunction in diabetes patients is 1.5-2 times higher than that in nondiabetic patients [41][42][43]. In recent years, the incidence of diabetes-related cognitive dysfunction has been increasing, becoming a serious social burden [44].…”

Section: Hydrogen Sulfide Improves Diabetes-associated Cognitive Dysf...mentioning

confidence: 99%

Hydrogen Sulfide Plays an Important Role by Regulating Endoplasmic Reticulum Stress in Diabetes-Related Diseases

Zhao

Liu

Yang

et al. 2022

IJMS

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Endoplasmic reticulum (ER) plays important roles in protein synthesis, protein folding and modification, lipid biosynthesis, calcium storage, and detoxification. ER homeostasis is destroyed by physiological and pharmacological stressors, resulting in the accumulation of misfolded proteins, which causes ER stress. More and more studies have shown that ER stress contributes to the pathogenesis of many diseases, such as diabetes, inflammation, neurodegenerative diseases, cancer, and autoimmune diseases. As a toxic gas, H2S has, in recent years, been considered the third most important gas signal molecule after NO and CO. H2S has been found to have many important physiological functions and to play an important role in many pathological and physiological processes. Recent evidence shows that H2S improves the body’s defenses to many diseases, including diabetes, by regulating ER stress, but its mechanism has not yet been fully understood. We therefore reviewed recent studies of the role of H2S in improving diabetes-related diseases by regulating ER stress and carefully analyzed its mechanism in order to provide a theoretical reference for future research.

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“…A recent epidemiological survey showed that type 1 diabetes increased during the COVID-19 pandemic [ 3 ].Diabetes causes acute and chronic problems and impairs cognitive function [ 4 ]. 1.5–2.0 times more likely to suffer cognitive impairment, or dementia than individuals without diabetes [ 2 , 5 , 6 ]. Diabetes increases the incidence of MCI and AD by 1.25 to 1.91 times, according to 144 prospective studies [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in Anti-Diabetic Cognitive Dysfunction Effect of Erigeron Breviscapus (Vaniot) Hand-Mazz

Zhou

Zhang

et al. 2022

Pharmaceuticals

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Diabetic cognitive dysfunction (DCD) is the decline in memory, learning, and executive function caused by diabetes. Although its pathogenesis is unclear, molecular biologists have proposed various hypotheses, including insulin resistance, amyloid β hypothesis, tau protein hyperphosphorylation hypothesis, oxidative stress and neuroinflammation. DCD patients have no particular treatment options and current pharmacological regimens are suboptimal. In recent years, Chinese medicine research has shown that herbs with multi-component, multi-pathway and multi-target synergistic activities can prevent and treat DCD. Yunnan is home to the medicinal herb Erigeron breviscapus (Vant.) Hand-Mazz. (EBHM). Studies have shown that EBHM and its active components have a wide range of pharmacological effects and applications in cognitive disorders. EBHM’s anti-DCD properties have been seldom reviewed. Through a literature study, we were able to evaluate the likely pathophysiology of DCD, prescribe anti-DCD medication and better grasp EBHM’s therapeutic potential. EBHM’s pharmacological mechanism and active components for DCD treatment were also summarized.

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Prediabetes and working memory in older adults

Cited by 18 publications

References 58 publications

Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes

Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes

Hydrogen Sulfide Plays an Important Role by Regulating Endoplasmic Reticulum Stress in Diabetes-Related Diseases

Advances in Anti-Diabetic Cognitive Dysfunction Effect of Erigeron Breviscapus (Vaniot) Hand-Mazz

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