Prediabetes Deserves More Attention: A Review

Lawal, Yakubu; Bello, Fatima; Kaoje, Yazid Suleiman

doi:10.2337/cd19-0101

Cited by 23 publications

(16 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Prediabetes represents an important public health concern, not only because it significantly increases the risk of progression to diabetes, but also because it has been associated with the development of diabetes-related complications [ 5 ]. Previous research suggests a bidirectional relationship between impaired glucose metabolism and depression, which means that each condition can increase the risk of developing the other [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study

et al. 2022

View full text Add to dashboard Cite

Older people are prone to frailness, present poor adherence to pharmacotherapy, and often have adverse drug effects. Therefore, it is important to develop effective and safe interventions to mitigate the burden of anxiety and depression disorders in this population. The aim of this study was to investigate the effect of vitamin D supplementation on the anxiety and depression status of elderly people with prediabetes. Participants were randomly assigned a weekly dose of vitamin D3 of 25,000 IU (n = 45, mean age 73.10 ± 7.16 years) or nothing (n = 45, mean age 74.03 ± 7.64 years), in addition to suggested lifestyle measures. The State-Trait Anxiety Inventory subscales (STAI-T and STAI-S) and the Patient Health Questionnaire-9 (PHQ-9) were used to evaluate anxiety and depression levels, respectively, at baseline, 6, and 12 months. A total of 92.68% of the participants in the vitamin D group and 97.14% of the controls exhibited vitamin D deficiency (<20 ng/mL) at baseline. Mean STAI-T scores were lower in supplemented individuals than in the control group at 6 (38.02 ± 9.03 vs. 43.91 ± 7.18, p = 0.003) and 12 months (32.35 ± 7.77 vs. 44.97 ± 7.78, p < 0.001). The same pattern was evident for STAI-S scores at 6 (37.11 ± 7.88 vs. 43.20 ± 9.33, p = 0.003) and 12 months (32.59 ± 6.45 vs. 44.60 ± 9.53, p < 0.001). Supplemented participants demonstrated lower mean PHQ-9 scores compared to controls at 6 (15.69 ± 6.15 vs. 19.77 ± 8.96, p = 0.021) and 12 months (13.52 ± 5.01 vs. 20.20 ± 8.67, p < 0.001). Participants with deficiency and insufficiency at baseline experienced equal benefits of supplementation in terms of anxiety and depression scores. In conclusion, in a high-risk population, a weekly vitamin D supplementation scheme was effective in alleviating anxiety and depression symptoms. More studies are needed to elucidate the relevant mechanisms.

show abstract

Section: Introductionmentioning

confidence: 99%

Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Likewise, our study found that being physically active was beneficial for reversion from prediabetes to normoglycemia. Moreover, the potential reason underlying the benefits of reversion from prediabetes to normoglycemia for the risk of death was primarily lifestyle modification …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the potential reason underlying the benefits of reversion from prediabetes to normoglycemia for the risk of death was primarily lifestyle modification. 29 …”

Section: Discussionmentioning

confidence: 99%

Risk of Death Associated With Reversion From Prediabetes to Normoglycemia and the Role of Modifiable Risk Factors

Cao

Wen

et al. 2023

JAMA Netw Open

View full text Add to dashboard Cite

ImportanceIndividuals with prediabetes have a higher risk of death than healthy individuals. However, previous findings have suggested that individuals with reversion from prediabetes to normoglycemia may not have a lower risk of death compared with individuals with persistent prediabetes.ObjectivesTo investigate the associations between changes in prediabetes status and risk of death and to elucidate the roles of modifiable risk factors in these associations.Design, Setting, and ParticipantsThis population-based prospective cohort study used data from 45 782 participants with prediabetes from the Taiwan MJ Cohort Study who were recruited between January 1, 1996, and December 31, 2007. Participants were followed up from the second clinical visit to December 31, 2011, with a median (IQR) follow-up of 8 (5-12) years. Participants were categorized into 3 groups according to changes in their prediabetes status within a 3-year period after initial enrollment: reversion to normoglycemia, persistent prediabetes, and progression to diabetes. Cox proportional hazards regression models were used to examine the associations between changes in prediabetes status at baseline (ie, the second clinical visit) and risk of death. Data analysis was performed between September 18, 2021, and October 24, 2022.Main Outcomes and MeasuresAll-cause mortality, cardiovascular disease (CVD)–related mortality, and cancer-related mortality.ResultsOf 45 782 participants with prediabetes (62.9% male; 100% Asian; mean [SD] age, 44.6 [12.8] years), 1786 (3.9%) developed diabetes and 17 021 (37.2%) reverted to normoglycemia. Progression from prediabetes to diabetes within a 3-year period was associated with higher risks of all-cause death (hazard ratio [HR], 1.50; 95% CI, 1.25-1.79) and CVD-related death (HR, 1.61; 95% CI, 1.12-2.33) compared with persistent prediabetes, while reversion to normoglycemia was not associated with a lower risk of all-cause death (HR, 0.99; 95% CI, 0.88-1.10), cancer-related death (HR, 0.91; 95% CI, 0.77-1.08), or CVD-related death (HR, 0.97; 95% CI, 0.75-1.25). Among individuals who were physically active, reversion to normoglycemia was associated with a lower risk of all-cause death (HR, 0.72; 95% CI, 0.59-0.87) compared with those with persistent prediabetes who were physically inactive. Among individuals with obesity, risk of death varied between those who experienced reversion to normoglycemia (HR, 1.10; 95% CI, 0.82-1.49) and those who had persistent prediabetes (HR, 1.33; 95% CI, 1.10-1.62).Conclusions and RelevanceIn this cohort study, although reversion from prediabetes to normoglycemia within a 3-year period did not mitigate the overall risk of death compared with persistent prediabetes, risk of death associated with reversion to normoglycemia varied based on whether individuals were physically active or had obesity. These findings highlight the importance of lifestyle modification among those with prediabetes status.

show abstract

“…El interés por la prediabetes se ha incrementado notoriamente en las dos décadas de este siglo visto su trascendencia como estado metabólico y condición predisponente para la progresión futura a la diabetes tipo 2 (DM2) y enfermedad cardiovascular aterosclerótica (ECVA), además de que confiere una alta probabilidad de desarrollar muchas de las patologías normalmente asociadas a esa enfermedad, tales como retinopatía diabética, neuropatía periférica, enfermedad renal diabética y complicaciones macrovasculares 1 . La prediabetes representa una etapa intermedia de disglucemia a lo largo del continuo que va desde el estado normal a la Diabetes, se identifica mediante mediciones de laboratorio: valor de glucosa en ayuna, valor de glucosa 2 horas después de una carga de 75 grs de glucosa.…”

Section: Prediabetes and Its Complex Spectrum As A Challenge To Daily...unclassified

Prediabetes y su complejo espectro como un reto en la práctica clínica diaria

Arocha-Rodulfo,

Martinez-Colarossi,

Marchán-Solano

et al. 2023

Rev Cien CMDLT

View full text Add to dashboard Cite

La prediabetes es reconocida como un estado metabólico y como un factor predisponente individual a una alta probabilidad de progresar a diabetes en el futuro, personas con prediabetes tienen un riesgo elevado de desarrollar patologías asociadas con esa enfermedad, como retinopatía diabética, neuropatías, nefropatías y complicaciones macrovasculares. Se estima que la incidencia de Diabetes Mellitus tipo 2 (DMT2) en pacientes con prediabetes es significativamente mayor que en paciente con tolerancia a la glucosa normal (TGN). En los sujetos que fueron diagnosticados con IFG e IGT en combinación, el porcentaje anual de riesgo de desarrollar DMT2 incrementó en 10%. Esto sugiere que la IFG e IGT tienen un rol aditivo al factor de riesgo de padecer DMT2. La aparición de patologías cardiovasculares y la mortalidad asociada en individuos con prediabetes en comparación con NGT es conocido por ser significativamente elevado (mayor al 50%). Debido a que la progresión a DMT2, enfermedad cardiovascular aterosclerótica (ECVA) o complicaciones micro o macrovasculares pueden ser prevenidas, la aproximación clínica debe invertir más tiempo en desarrollar un abordaje sistémico, enfocado en la heterogeneidad de la fisiopatología de esta condición. El propósito de esta revisión es actualizar conceptos sobre esta condición que pasa desapercibida para muchos médicos no especialistas en el tema y que realmente hay que considerarla como una condición de riesgo importante para la DM2 y la ECVA.

show abstract

Prediabetes Deserves More Attention: A Review

Cited by 23 publications

References 76 publications

Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study

Vitamin D Alleviates Anxiety and Depression in Elderly People with Prediabetes: A Randomized Controlled Study

Risk of Death Associated With Reversion From Prediabetes to Normoglycemia and the Role of Modifiable Risk Factors

Prediabetes y su complejo espectro como un reto en la práctica clínica diaria

Contact Info

Product

Resources

About