Prediabetes diagnosis is associated with the progression of coronary artery calcification: The Kangbuk Samsung Health Study

Choi, In Young; Chang, Yoosoo; Cho, Yoosun; Kang, Jeonggyu; Jung, Hyun Suk; Byrne, Christopher D.; Ryu, Seungho

doi:10.1111/dom.14797

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…The evidence on the dose-response relationships between HbA1c and AC were limited. Previous researchers have found that higher HbA1c was independently associated with advanced AAC scores, CAC risk, and CAC progression [ 10 – 12 ], however, they did not investigate the dose-response relationships between HbA1c and these outcomes. The current study showed a nearly linear dose-response relationships between HbA1c and AAC, which provided evidence for preventing AC through reducing HbA1c levels.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have investigated the effects of HbA1c on AC, especially coronary artery calcification (CAC). The cross-sectional and longitudinal study showed that higher HbA1c is independently associated with advanced CAC progression among individuals with or without diabetes [ 10 , 11 ]. Previous studies have reported that CAC is rarely present without AAC, and AAC typically predates CAC [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between hemoglobin A1c and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013–2014

Cai,

Wang,

Chen

et al. 2024

BMC Cardiovasc Disord

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Background Hemoglobin A1c (HbA1c), a “gold standard” for the assessment of glycemic control, was associated with an increased risk of cardiovascular disease and coronary artery calcification. However, its effects on abdominal aortic calcification (AAC) are uncertain. The present study comprehensively investigated the association between HbA1c and AAC in the 2013–2014 National Health and Nutrition Examinations Surveys. Methods Among 1,799 participants ≥ 40 years, dual-energy X-ray absorptiometry-derived AAC was quantified using the Kauppila score (AAC-24). Severe AAC was defined as a total AAC-24 > 6. Weighted linear regression models and logistic regression models were used to determine the effects of HbA1c on AAC. The restricted cubic spline model was used for the dose-response analysis. Results The mean AAC-24 of participants was 1.3, and 6.7% of them suffered from severe AAC. Both AAC-24 and the prevalence of severe AAC increased with the higher tertile of HbA1c (P < 0.001). Elevated HbA1c levels would increase the AAC-24 (β = 0.73, 95% CI: 0.30–1.16) and the risk of severe AAC (OR = 1.63, 95% CI: 1.29–2.06), resulting in nearly linear dose-response relationships in all participants. However, this positive correlation were not statistically significant when participants with diabetes were excluded. Furthermore, subgroup analysis showed significant interactions effect between HbA1c and hypertension on severe AAC with the OR (95% CI) of 2.35 (1.62–3.40) for normotensives and 1.39 (1.09–1.79) for hypertensives (P for interaction = 0.022). Conclusion Controlling HbA1c could reduce AAC scores and the risk of severe AAC. Glycemic management might be a component of strategies for preventing AAC among all participants, especially normotensives.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between hemoglobin A1c and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013–2014

Cai,

Wang,

Chen

et al. 2024

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…A large Korean cohort study showed an increased risk of CACS > 100 among patients with prediabetes, the prevalence being 12–31% higher than in subjects with normal fasting glucose. CAC progression was also more prominent in patients with prediabetes [ 30 ]. There is, however, diversity of opinion on this matter.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Coronary Artery Calcifications in Overweight or Obese Persons with Prediabetes: Can They Predict T2 Diabetes and Coronary Vascular Events?

Petkovic

Vuksanovic

Sagić

et al. 2023

JCM

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Background: It is difficult to predict the risk of developing atherosclerotic cardiovascular disease in subjects with prediabetes and obesity. The aim of this study was to assess risk factors for coronary artery calcifications (CACs) and the development of type 2 diabetes (T2D) and coronary vascular events (CVEs) after 7 years in 100 overweight or obese persons with prediabetes, according to the baseline coronary artery calcium score (CACS). Methods: Lipids, HbA1c, uric acid, and creatinine were assessed. Glucose, insulin, and c-peptide were determined during an oral glucose tolerance test. Multi-sliced computerized tomography with evaluation of CACS was performed. After 7 years, the subjects were assessed for T2D/CVE. Results: CACs were present in 59 subjects. No single biochemical marker could predict presence of a CAC. After 7 years, T2D developed in 55 subjects (61.8% initially had both IFG and IGT). A gain in weight was the only contributing factor for T2D. Nineteen subjects developed a CVE; increased initial clustering of HOMA-IR > 1.9, LDL > 2.6, and mmol/Land TGL > 1.7 mmol/L and higher CACS were present in that group. Conclusions: No risk factors for CACs could be identified. A gain in weight is associated with T2D development, as are higher CACS and clustering of high LDL+TGL+HOMA-IR with CVEs.

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Associations between metabolic score for visceral fat and the risk of cardiovascular disease and all-cause mortality among populations with different glucose tolerance statuses

Zhu

Zou

Guo

et al. 2023

Diabetes Research and Clinical Practice

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Prediabetes diagnosis is associated with the progression of coronary artery calcification: The Kangbuk Samsung Health Study

Cited by 7 publications

References 37 publications

Association between hemoglobin A1c and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013–2014

Association between hemoglobin A1c and abdominal aortic calcification: results from the National Health and Nutrition Examination Survey 2013–2014

Risk Factors for Coronary Artery Calcifications in Overweight or Obese Persons with Prediabetes: Can They Predict T2 Diabetes and Coronary Vascular Events?

Associations between metabolic score for visceral fat and the risk of cardiovascular disease and all-cause mortality among populations with different glucose tolerance statuses

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