Prediabetes y pronóstico clínico de los pacientes con cardiopatía isquémica y revascularización coronaria percutánea

Cueva-Recalde, Juan F.; Ruiz-Arroyo, José R.; García-Blanco, Francisco Roncalés

doi:10.1016/j.endonu.2015.11.007

Cited by 9 publications

(11 citation statements)

References 27 publications

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“…[8–13,15–28] All studies were published in English, except one in Spanish. [28] The mean age of enrolled patients across studies ranged from 51 to 70 years, and 71% of participants were men. All studies were of either retrospective or prospective cohort design, except 1 study, which was a prespecified substudy of a randomized controlled trial.…”

Section: Resultsmentioning

confidence: 99%

“…[8–13,15,18,19,21–28] Three studies did not report mortality data based on HbA1c levels in the articles; but we obtained data of 2 studies from a prior meta-analysis, [9,11] and data of the other study by contacting the primary authors. [23] In total, 18,041 participants were included for the pooled analysis, which showed a significantly increased risk of long-term mortality in patients with a high HbA1c level than those with a low HbA1c level (OR 1.76, 95%CI 1.44–2.16, P < .001, Fig.…”

Section: Resultsmentioning

confidence: 99%

“…[18,19,23,27,28] High HbA1c levels were associated with a significantly higher risk of MI (OR 1.69, 95%CI 1.07–2.67, P = .026). No significant heterogeneity was found ( I 2 = 0%, P = .407, Fig.…”

Section: Resultsmentioning

confidence: 99%

“…[14] However, a body of recent studies provided inconsistent findings. [15–28] Therefore, we performed a meta-analysis to determine the predictive effect of HbA1c level on clinical outcomes in nondiabetic patients with CAD.…”

Section: Introductionmentioning

confidence: 99%

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Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease

et al. 2017

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“…[5] The most common therapy for coronary artery disease patients is percutaneous coronary intervention (PCI). [6] …”

Section: Introductionmentioning

confidence: 99%

Comparison of clinical outcomes after drug-eluting stent implantation in diabetic versus nondiabetic patients in China

et al. 2017

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Diabetes mellitus (DM) has been proved to be a predictor of adverse outcomes after percutaneous coronary intervention (PCI). Drug-eluting stents (DESs) could reduce the adverse events in DM patients. In this study, we aimed to analyze the clinical outcome after DES implantation in diabetic versus nondiabetic patients in China. Totally, 200 Chinese DM patients and 400 Chinese non-DM patients were enrolled in this retrospective study. Compared with non-DM patients, DM patients were more likely to have a higher incidence of cardiac death (3.5% vs. 1.0%, P = .048), stent thrombosis (2.5% vs. 0.5%, P = .044), target lesion revascularization (6.0% vs. 1.8%, P = .005), target vessel failure (15.5% vs. 8.0%, P < .001), target lesion failure (14.0% vs. 4.3%, P < .001), myocardial infarction (4.5% vs. 1.5%, P = .030), and major adverse cardiac events (12.5% vs. 5.0%, P = .001) at 2-year follow-up. However, the incidence of target vessel revascularization (7.5% vs. 5.5%, P = .340) was similar between DB and non-DB patients. Patients with DB (hazard ratio [HR] = 2.54, P = .001), older than 80 years (HR = 1.33, P = .027) with hypercholesterolemia (HR = 1.03, P < .001), serum creatinine >177 μmol/L (HR = 3.04, P = .011), a history of cerebral vascular accident (HR = 4.29, P = .010), or a history of myocardial infarction (HR = 31.4, P < .001) were more likely to experience adverse events. In China, DM could also be served as an independent predictor of adverse outcomes after DES implantation. These patients should be reexamined more frequently.

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Prediabetes and major adverse cardiac events after acute coronary syndrome: An overestimated concept

Behnoush,

Maleki,

Arzhangzadeh

et al. 2024

Clinical Cardiology

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BackgroundUnlike diabetes, the effect of prediabetes on outcomes in patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) is not much investigated. We investigated the association between fasting glycemic status and major adverse cardiovascular and cerebrovascular events (MACCE) in patients with ACS undergoing PCI and had mid to long‐term follow‐up after coronary stenting.MethodsRegistry‐based retrospective cohort study included ACS patients who underwent PCI at the Tehran Heart Center from 2015 to 2021 with a median follow‐up of 378 days. Patients were allocated into normoglycemic, prediabetic, and diabetic groups. The primary and secondary outcomes were MACCE and its components, respectively. Unadjusted and adjusted Cox models were used to evaluate the association between glycemic status and outcomes.ResultsAmong 13 682 patients, 3151 (23%) were prediabetic, and 5834 (42.6%) were diabetic. MACCE risk was significantly higher for diabetic versus normoglycemic (adjusted hazard ratio [aHR]: 1.22, 95% confidence interval [CI]: 1.06–1.41), but nonsignificantly higher for prediabetic versus normoglycemic (aHR: 0.95, 95% CI: 0.78–1.10). All‐cause mortality risk was significantly higher in diabetic versus normoglycemic (aHR: 1.42, 95% CI: 1.08–1.86), but nonsignificantly higher for prediabetic versus normoglycemic (aHR: 1.15, 95% CI: 0.84–1.59). Among other components of MACCE, only coronary artery bypass grafting was significantly higher in diabetic patients, and not prediabetic, compared with normoglycemic.ConclusionsPrediabetic ACS patients undergoing PCI, unlike diabetics, are not at increased risk of MACCE and all‐cause mortality. While prediabetic patients could be regarded as having the same risk as nondiabetics, careful consideration to provide more intensive pre‐ and post‐PCI care in diabetic patients is mandatory.

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Prediabetes y pronóstico clínico de los pacientes con cardiopatía isquémica y revascularización coronaria percutánea

Cited by 9 publications

References 27 publications

Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease

Glycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease

Comparison of clinical outcomes after drug-eluting stent implantation in diabetic versus nondiabetic patients in China

Prediabetes and major adverse cardiac events after acute coronary syndrome: An overestimated concept

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