Prediagnostic dietary intakes of vitamin A and β-carotene are associated with hepatocellular-carcinoma survival

Zhang, Daoming; Luo, Yun; Yishake, Dinuerguli; Liu, Zhao-Yan; He, Tong-Tong; Luo, Yan; Zhang, Yaojun; Fang, Aiping; Zhu, Huilian

doi:10.1039/c9fo02468a

Cited by 16 publications

(11 citation statements)

References 43 publications

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“…Other markers have been reported, but most performed an unsatisfactory sensitivity or specificity. There are experiments which can prove that the progression of HCC can be inhibited by raising the expression of three main genes which are cysteine sulfinic acid decarboxylase (CSAD), glutamic-oxaloacetic transaminase 2 (GOT2) and suppressor of cytokine signaling 2 (SOCS2) through METTL14 [17,18,19]. Ribosomal protein S11 (RPS11) overexpression is affiliated with variety of malignancies and tumor recurrence, which can be used as a potential biomarker for predicting the prognosis of patients who have received radical resection of HCC [20].…”

Section: Discussionmentioning

confidence: 99%

The expression and clinical significance of TPM4 in hepatocellular carcinoma

Li¹,

Tao²,

Zhang³

et al. 2021

Int. J. Med. Sci.

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Hepatocellular carcinoma (HCC) is known as the fifth most common cancer in the world for its poor prognosis. New diagnostic markers and treatments are urgent to discover. To evaluate the protein expression of Tropomyosin4 (TPM4) and investigate its prognostic value in HCC, we collected 110 patients with different degrees of HCC and 10 patients with normal hepatic tissues and performed immunohistochemistry. Western bot was used to evaluate the expression of TPM4 in three HCC cell lines (HepG2, Huh7, SMMC-7721) and normal liver cell line LO2, as well as 7 HCC tissues and 7 normal hepatic tissues. The results of TPM4 staining revealed that TPM4 expression in HCC was higher than that in normal hepatic tissues, which was positive in 51.8% (n=57) and negative in 48.2% (n=53) while in normal hepatic tissues positive staining was in 10% (n=1) and negative staining was in 90% (n=9) (P=0.011). And the expression of TPM4 was related to pT status, grade and stage (P<0.001, P=0.015 and P<0.001, respectively). Western blot results indicated that TPM4 was high expressed in HCC cell line and HCC tissues. In conclusion, we believe that TPM4 can be applied as a diagnostic and prognostic marker to assist the management of HCC.

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Section: Discussionmentioning

confidence: 99%

The expression and clinical significance of TPM4 in hepatocellular carcinoma

Li¹,

Tao²,

Zhang³

et al. 2021

Int. J. Med. Sci.

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“…Previous human studies have reported that reduced levels of β-carotene can be detected in patients with different cancers, including oral cancer [398], breast cancer [399], prostate cancer [400], pancreatic cancer [338], and malignant pleural mesothelioma [401]. Moreover, numerous epidemiological studies have indicated that dietary intakes of βcarotene, obtained from fruits and vegetables, may reduce cancer mortality [402] and protect against the development of some gastrointestinal cancers, such as esophageal cancer [318], gastric cancer [316], colon cancer [312], pancreatic cancer, and hepatocellular carcinoma [314,324]. Likewise, consumption of this carotenoid exerted a chemopreventive effect against the development of breast cancer [323,403], lung cancer [404], head and neck cancer [333], and non-Hodgkin lymphoma [325].…”

Section: Human Studiesmentioning

confidence: 99%

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

et al. 2021

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Acute inflammation is a key component of the immune system’s response to pathogens, toxic agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing pathogenic factors and restoring tissue homeostasis. However, uncontrolled acute inflammatory response may lead to chronic inflammation, which is involved in the development of many diseases, including cancer. Nowadays, the need to find new potential therapeutic compounds has raised the worldwide scientific interest to study the marine environment. Specifically, microalgae are considered rich sources of bioactive molecules, such as carotenoids, which are natural isoprenoid pigments with important beneficial effects for health due to their biological activities. Carotenoids are essential nutrients for mammals, but they are unable to synthesize them; instead, a dietary intake of these compounds is required. Carotenoids are classified as carotenes (hydrocarbon carotenoids), such as α- and β-carotene, and xanthophylls (oxygenate derivatives) including zeaxanthin, astaxanthin, fucoxanthin, lutein, α- and β-cryptoxanthin, and canthaxanthin. This review summarizes the present up-to-date knowledge of the anti-inflammatory and anticancer activities of microalgal carotenoids both in vitro and in vivo, as well as the latest status of human studies for their potential use in prevention and treatment of inflammatory diseases and cancer.

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“…Furthermore, retinol has a protective capacity against digestive cancers (Xie et al, 2019). Additionally, an increased dietary supplement of Vit A and β-carotene can improve hepatocellular carcinoma prognosis with an increased survival rate (Zhang et al, 2020).…”

Section: Vitaminsmentioning

confidence: 99%

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

Ferdous

Yusof

2021

Front. Pharmacol.

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Though cancer therapeutics can successfully eradicate cancerous cells, the effectiveness of these medications is mostly restricted to several deleterious side effects. Therefore, to alleviate these side effects, antioxidant supplementation is often warranted, reducing reactive species levels and mitigating persistent oxidative damage. Thus, it can impede the growth of cancer cells while protecting the normal cells simultaneously. Moreover, antioxidant supplementation alone or in combination with chemotherapeutics hinders further tumor development, prevents chemoresistance by improving the response to chemotherapy drugs, and enhances cancer patients’ quality of life by alleviating side effects. Preclinical and clinical studies have been revealed the efficacy of using phytochemical and dietary antioxidants from different sources in treating chemo and radiation therapy-induced toxicities and enhancing treatment effectiveness. In this context, algae, both micro and macro, can be considered as alternative natural sources of antioxidants. Algae possess antioxidants from diverse groups, which can be exploited in the pharmaceutical industry. Despite having nutritional benefits, investigation and utilization of algal antioxidants are still in their infancy. This review article summarizes the prospective anticancer effect of twenty-three antioxidants from microalgae and their potential mechanism of action in cancer cells, as well as usage in cancer therapy. In addition, antioxidants from seaweeds, especially from edible species, are outlined, as well.

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Prediagnostic dietary intakes of vitamin A and β-carotene are associated with hepatocellular-carcinoma survival

Abstract: Vitamin A and its precursor (β-carotene) have been linked with cancer incidence and mortality.

Cited by 16 publications

References 43 publications

The expression and clinical significance of TPM4 in hepatocellular carcinoma

The expression and clinical significance of TPM4 in hepatocellular carcinoma

Anti-Inflammatory and Anticancer Effects of Microalgal Carotenoids

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

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