Prediagnostic Helicobacter pylori Antibodies and Colorectal Cancer Risk in an Elderly, Caucasian Population

Abstract

The results of our study do not support an association between H. pylori infection and colorectal cancer risk in this elderly, mostly Caucasian population.

Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

“…In agreement with our results, two recently published nested case-control studies using also the multiplex serology technique to test H. pylori infection reported no statistically significant association between H. pylori seropositivity and colorectal, colon, or rectum cancer (Epplein et al, 2013; Blase et al, 2016). They did not find an association with CagA seropositivity either.…”

“…The most established involve the increase of gastrin secretion, the modification of gut microbiota and the chronic inflammation status (Chang and Parsonnet, 2010; Tatishchev et al, 2012; Papastergiou, 2016). However, two recent publications, one reporting results from a nested case-control study including a Caucasian population from the US (Blase et al, 2016) and another from a cohort study in Germany (Chen et al, 2016), not included in the above mentioned meta-analyses, did not find a statistically significant association between H. pylori infection and CRC.…”

The association between Helicobacter pylori infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking

“…Abbreviation: HP, Helicobacter pylori; Hx, history disagree. 12,13,26,27 The reason for this discrepancy is currently uncertain, but our results suggest that age is an important factor that determines the association between H. pylori and ACN. In line with our results, studies by Limburg et al, 28 Chen et al, 12 and Blase et al, 13 suggesting that H. pylori did not increase the level of gastrin in the elderly.…”

“…However, the results should be interpreted with caution, because the study was not adjusted for potential confounders such as family history of CRC, cigarette smoking, and body mass index (BMI) . Furthermore, 2 recent cohort studies showed no association between H. pylori and CRC in patients aged ≥50 and ≥56 years . These conflicting previous results prompted us to evaluate the association between H. pylori infection and ACN using a large health checkup database.…”

“…11 Furthermore, 2 recent cohort studies showed no association between H. pylori and CRC in patients aged ≥50 and ≥56 years. 12,13 These conflicting previous results prompted us to evaluate the association between H. pylori infection and ACN using a large health checkup database. We hypothesized that the association between H. pylori infection and ACN is weakened in elderly patients, considering that the immune response to H. pylori infection varies with age and affects gastric inflammation.…”