Prediagnostic Plasma Pyridoxal 5′-Phosphate (Vitamin B6) Levels and Invasive Breast Carcinoma Risk: The Multiethnic Cohort

Lurie, Galina; Wilkens, Lynne R.; Shvetsov, Yurii B.; Ollberding, Nicholas J.; Franke, Adrian A.; Henderson, Brian E.; Kolonel, Laurence N.; Goodman, Marc T.

doi:10.1158/1055-9965.epi-12-0717-t

Cited by 12 publications

(9 citation statements)

References 40 publications

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“…Our finding for an inverse association with higher serum PLP levels on HCC development is consistent with recent data from large longitudinal cohort studies that showed statistically significant strong inverse associations between circulating PLP and incidence of lung cancer (28), colorectal cancer (29) and breast cancer (30). The mechanism(s) by which vitamin B 6 protects against development of these cancers, and HCC in particular, is unknown.…”

Section: Discussionsupporting

confidence: 92%

Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma

Butler

Arning

Wang

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Rats fed diets deficient in choline develop hepatocellular carcinoma (HCC). Tumor DNA from these animals is characteristically hypomethylated, suggesting that disruption of the one-carbon metabolism pathway is an underlying mechanism for hepatocarcinogenesis. Prospective studies in humans on circulating choline and other one-carbon metabolites and HCC risk have been lacking. Methods We prospectively examined the association between prediagnostic serum concentrations of one-carbon metabolites including betaine, choline, cystathionine, homocysteine, methionine, 5-methyltetrahydrofolate (5-MTHF), pyridoxal-5-phosphate (PLP, the bioactive form of vitamin B6) and S-adenosylmethionine (SAM), and risk of developing HCC based on a nested case-control study of 297 incident cases and 631 matched controls from a cohort of 18,244 men in Shanghai, China. Logistic regression methods were used to calculate odds ratios (OR) and 95% confidence intervals (CI) adjusted for established risk factors for HCC. Results Serum choline and PLP were associated with statistically significant reduced risk of HCC, while serum cystathionine, methionine and SAM were associated with increased HCC risk (all Ptrend<0.05). The inverse associations for HCC risk with choline and PLP remained statistically significant after adjusting for all potential confounders. The multivariate-adjusted ORs (95% CIs) for the highest versus lowest quintiles of serum choline and PLP were 0.35 (0.16, 0.78) (P=0.010) and 0.44 (0.25, 0.78) (P=0.005), respectively. There were no associations for HCC risk with 5-MTHF, betaine, or homocysteine. Conclusion The inverse associations between choline and vitamin B6 and the risk of HCC development are novel and warrant further investigation. Impact Identifying new modifiable factors for HCC prevention are warranted.

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Section: Discussionsupporting

confidence: 92%

Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma

Butler

Arning

Wang

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Among the five nested case–control studies, two studies in one article (Wu et al , 1999a) only adjusted for age, menopausal status and year of blood donation, and a positive but not significant association of serum PLP levels with the risk of breast cancer was found. Three studies (Zhang et al , 2003; Lin et al , 2008; Lurie et al , 2012) adjusted for the most known risk factors of breast cancer, and a significantly combined effect (Zhang et al , 2003; Lin et al , 2008; Lurie et al , 2012) was found (0.76 (0.62–0.94), P =0.01, I 2 =0.00%).…”

Section: Resultsmentioning

confidence: 93%

“…Three studies that did not report the risk estimate were also excluded (Potera et al , 1977; Goodman et al , 2001; Schroecksnadel et al , 2003). Finally, 23 articles (Thorand et al , 1998; Wu et al , 1999a; Levi et al , 2001; Shrubsole et al , 2001; Feigelson et al , 2003; Zhang et al , 2003; Zhu et al , 2003; Lajous et al , 2006a; Lajous et al , 2006b; Cho et al , 2007; Kabat et al , 2008; Lin et al , 2008; Xu et al , 2008; Ma et al , 2009a; Ma et al , 2009b; Maruti et al , 2009a; Stevens et al , 2010; Chou et al , 2011; Shrubsole et al , 2011; Zhang et al , 2011; Lurie et al , 2012; Bassett et al , 2013; Yang et al , 2013) were included in this meta-analysis. The detailed steps of our literature search are shown in Supplementary Material.…”

Section: Resultsmentioning

confidence: 99%

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Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose–response meta-analysis

Kang

Zhang

2013

Br J Cancer

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Background:Epidemiological studies evaluating the association of vitamin B6, vitamin B12 and methionine with breast cancer risk have produced inconsistent results.Methods:Pertinent studies were identified by a search in PubMed and Web of Knowledge. Random-effect model was used. Dose–response relationship was assessed by restricted cubic spline.Results:The combined relative risk (95% confidence interval) of breast cancer for the highest vs lowest category of serum pyridoxal 5′-phosphate (PLP, active form of vitamin B6) levels and dietary methionine intake was 0.80 (0.66–0.98, P=0.03) and 0.94 (0.89–0.99, P=0.03), respectively, and the associations of breast cancer with higher serum PLP levels and dietary methionine intake were significant among post-menopausal women, but not among pre-menopausal women. The inverse association between breast cancer risk and dietary vitamin B6 intake, serum vitamin B12 levels and dietary vitamin B12 intake was not significant overall. Linear dose–response relationship was found, and the risk of breast cancer decreased by 23% (P<0.00) for every 100 pmol ml−1 increment in PLP levels and 4% (P=0.05) for every 1 g per day increment in dietary methionine intake, respectively.Conclusion:Serum PLP levels and methionine intake might be inversely associated with breast cancer risk, especially among postmenopausal women, which need to be confirmed.

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“…For this reason, the square of maximum at 420 nm gradually decreases for 3 rd BC stage. The low level of vitamin B6 in blood was detected in many investigations for patients with advanced BC [20,21]. Peak at 335 nm is defined by tryptophan and tyrosine-containing peptides [18].…”

Section: The Results and Their Discussionmentioning

confidence: 99%

Fluorescent diagnostics of benign breast diseases and breast cancer

Maryakhina

Korneva

Chekurov

et al. 2017

J-BPE

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Abstract. In the study the spectra of fluorescence excitation and autofluorescence of histological sections with different pathological processes in breast were measured. Additionally, element composition of the tissues was investigated by scanning electron microscopy. It has been shown that spectra of fluorescence excitation of benign breast diseases (fibroadenoma and fibrocystic breast disease) have low maximum at 232 nm and high maximum at 260 nm. Also, fluorescence spectra of histological samples change during tumor growth and have two maxima (335 and 420 nm). The registered spectra are result of emission of such fluorophores as fatty acids, tryptophan, NADH, vitamin B6, collagen and bilirubin. The obtained spectral data correlate well with data of element analysis. Selenium status of the tissues was investigated by scanning electronic microscope. High concentration if selenium was detected only in fibroadenoma. In breast cancer samples and fibrocystic breast disease low selenium content was detected. It may confirm higher risk for malignant transformation of fibrocystic breast disease than fibroadenoma. Our results may be helpful for cancer diagnostics and for prognosis prediction.

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Prediagnostic Plasma Pyridoxal 5′-Phosphate (Vitamin B6) Levels and Invasive Breast Carcinoma Risk: The Multiethnic Cohort

Cited by 12 publications

References 40 publications

Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma

Prediagnostic Levels of Serum One-Carbon Metabolites and Risk of Hepatocellular Carcinoma

Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose–response meta-analysis

Fluorescent diagnostics of benign breast diseases and breast cancer

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