Predialysis hypernatremia is a prognostic marker in acute kidney injury in need of renal replacement therapy

Mendes, Renata; Soares, Márcio; Valente, Carla; Suassuna, José Hermógenes Rocco; Rocha, Eduardo; Maccariello, Elizabeth

doi:10.1016/j.jcrc.2015.05.023

Cited by 21 publications

(23 citation statements)

References 39 publications

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“…We think the electrolyte disorder inside body may account for the predictive ability of Na + for AKI. Mendes et al regarded predialysis hypernatremia as a prognostic marker in AKI in need of renal replacement therapy [27]. Wu et al…”

Section: Discussionmentioning

confidence: 99%

Predictive Role of Hypernatremia for Acute Kidney Injury in Patients with Sepsis

Zhi

Lin

Dong

et al. 2019

Preprint

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Introduction Septic acute kidney injury (AKI), identified when both sepsis and AKI present, is a syndrome of acute function impairment and organ damage, accounting for ~50% AKI in ICU (Intensive Care Unit)Method This study retrospectively reviewed 591 patients who were diagnosed of sepsis and admitted to the ICU of Beijing Friendship Hospital from January 2009 to December 2014. According to the concentration of serum sodium, the 591 patients were further divided into three groups: normal group, hyponatremia group and hypernatremia group.Result PaCO 2 (P=0.014), concentration of Na + (P<0.001) and Cl - (P<0.001), BUN (P<0.001), APACHE score (P<0.001), SOFA score (P<0.001) and Glasgow score (P<0.001) showed significant differences. CK (P=0.012; OR=1.000), BUN (P=0.002; OR=1.047), Cl - (P<0.001;OR=1.255), lactic acid (P=0.001;OR=1.244), and HCO 3 - (P<0.001;OR=1.180) may be risk factors for hypernatremia in patients with sepsis. APACHE score (P=0.028;OR=1.222) and CK (P=0.014;or=1.003) may be risk factors for AKI in patients with hypernatremia. Na + suggested a good predictive ability for AKI (P<0.001; AUC: 0.586) but not for death (P=0.104)Conclusion Hypernatremia is independently associated with an increased risk and has a predictive ability of AKI in patients with sepsis.

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Section: Discussionmentioning

confidence: 99%

Predictive Role of Hypernatremia for Acute Kidney Injury in Patients with Sepsis

Zhi

Lin

Dong

et al. 2019

Preprint

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“…Several studies have reported that the mortality of patients with severe hypernatremia who underwent conventional treatment is 75% -89.1% (8)(9)(10). Therefore, CVVH treatment might be more effective than conventional treatment for the management of acute severe hypernatremia in critically ill patients (21).…”

Section: Discussionmentioning

confidence: 99%

“…Although the incidence of severe hypernatremia in critically ill patients is low (2,6,7), the mortality rates are still high (67.4%-87%) (8)(9)(10). Critically ill patients with hypernatremia exhibit a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

The Reduction Rate of Serum Sodium and Mortality in Patients Undergoing Continuous Venovenous Hemofiltration for Acute Severe Hypernatremia

Liu

Bai

et al. 2016

The American Journal of the Medical Sciences

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“…Normally, the level of sodium in human blood plasma is maintained in the narrow range of concentrations (1,2). Higher concentrations of sodium in the blood plasma reveal elderly people and children with symptoms of diarrhea (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…Higher concentrations of sodium in the blood plasma reveal elderly people and children with symptoms of diarrhea (3)(4)(5). Hypernatremia is often revealed by the patients of intensive therapy departments creating the risk for mortality (1,(6)(7)(8). Hypernatremia leads to an increase of the internal environment osmolality (9) causing a drop in osmotic pressure between the extracellular and intracellular body fl uid.…”

Section: Introductionmentioning

confidence: 99%

Volume regulation of muscle cells in the carp Cyprinus carpio in response to hypernatremia

Martemyanov¹,

Poddubnaya²

2019

BLL

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BACKGROUND: Hypernatremia supports the movement of water from the intracellular to the intercellular space. This shift leads to cells shrinkage and disruption of intracellular processes, representing risk factors of morbidity and mortality in clinical circumstances. On the other hand, hypernatremia triggers protective mechanisms that counteract damage of cells. OBJECTIVES: To determine in experiments in vivo the ranges of sodium content regulation in the blood plasma of carp characterizing the norm and hypernatremia. To identify the patterns volume regulation of skeletal muscles cells in response to hypernatremia. METHODS: Carps were acclimating for 3 weeks to a different salinity in the range of 0-12 g/L. In the plasma and muscle tissue the concentration of sodium, potassium, calcium and magnesium was determined by the method of fl ame spectrophotometry. Water content in the muscles has been additionally determined. RESULTS: Carps acclimated in the salinity range of 0-6 g/L, maintained the concentration of sodium in blood plasma within of the range of 129-135 mmol/L (normonatremia). In the salinity zone of 6-12 g/L concentration of sodium in the blood plasma of fi sh has increased to 207 mmol/L (hypernatremia). Hypernatremia was causing the increase of the sodium, potassium, calcium and magnesium content in carp muscles and the drop of water level. CONCLUSIONS: Muscle tissue of carp adapts to hypernatremia by means of increasing inorganic ions by 70.8 % and organic osmolytes by 29.2 % (Fig. 2, Ref. 51).

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Predialysis hypernatremia is a prognostic marker in acute kidney injury in need of renal replacement therapy

Cited by 21 publications

References 39 publications

Predictive Role of Hypernatremia for Acute Kidney Injury in Patients with Sepsis

Predictive Role of Hypernatremia for Acute Kidney Injury in Patients with Sepsis

The Reduction Rate of Serum Sodium and Mortality in Patients Undergoing Continuous Venovenous Hemofiltration for Acute Severe Hypernatremia

Volume regulation of muscle cells in the carp Cyprinus carpio in response to hypernatremia

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