Predictability of Painful Stimulation Modulates Subjective and Physiological Responses

Oka, Shunichi; Chapman, C. Richard; Kim, Barkhwa; Shimizu, Osamu; Noma, Noboru; Takeichi, Osamu; Imamura, Yoshiki; Oi, Yoshiyuki

doi:10.1016/j.jpain.2009.07.009

Cited by 52 publications

(36 citation statements)

References 47 publications

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“…Moreover, nociceptive and nonnociceptive trials were interspersed at random, with no warning as to which trial was about to appear, which could have increased pain unpleasantness to nonnociceptive stimuli. It is known that uncertainty about the timing of a painful stimulus can increase pain unpleasantness ratings (Oka et al 2010, Price et al 1980 and that expecting to receive a painful stimulus can actually increase the perceived painfulness of a nonpainful or mildly painful stimulus (Atlas et al 2010, Sawamoto et al 2000. Thus, it is also possible that the design of the study, which involved expecting painful stimulation on some trials but not knowing when these trials were going to occur, led subjects to experience a greater sense of pain even in response to stimuli that were not intended to be painful.…”

Section: Wwwannualreviewsorg • Social Pain and The Brain 617mentioning

confidence: 99%

Social Pain and the Brain: Controversies, Questions, and Where to Go from Here

Eisenberger

2015

Annu. Rev. Psychol.

284

213

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Emerging evidence has shown that social pain-the painful feelings that follow from social rejection, exclusion, or loss-relies on some of the same neural regions that process physical pain, highlighting a possible physicalsocial pain overlap. However, the hypothesis that physical pain and social pain rely on shared neural systems has been contested. This review begins by summarizing research supporting the physical-social pain overlap. Next, three criticisms of this overlap model are presented and addressed by synthesizing available research. These criticisms include the suggestions that (a) neural responses to social pain are indicative of conflict detection processes, rather than distress; (b) all negative affective processes, rather than social pain specifically, activate these pain-related neural regions; and (c) neural responses to social (and physical) pain reflect the processing of salience, rather than hurt. Implications of these findings for understanding social and physical pain are discussed, and key next steps are suggested.

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Section: Wwwannualreviewsorg • Social Pain and The Brain 617mentioning

confidence: 99%

Social Pain and the Brain: Controversies, Questions, and Where to Go from Here

Eisenberger

2015

Annu. Rev. Psychol.

284

213

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“…Mixed effect model statistical analyses revealed that SEP and VAS score decreased significantly with increasing mixture concentration ( Clinical observations suggest that the perceived intensity of a painful event increases as the unpredictability of its occurrence increases. Therefore, third, we examined the effect of varying stimulus predictability on SEP and pain report (PR) and fear report (FR) scores in 25 healthy volunteers experiencing repeated noxious fingertip shocks (Oka et al, 2010). Each volunteer was exposed to high and low stimulus intensities administered in four stimulus patterns defined by the stimulus sequence (SEQ) and interstimulus interval (ISI) as follows: A) serial stimulus intensity SEQ with a fixed ISI; B) serial stimulus intensity SEQ with varying ISI; C) random stimulus intensity SEQ with fixed ISI; and D) random stimulus intensity SEQ with varying ISI.…”

Section: Pain Research Using Sepsmentioning

confidence: 99%

Movement-Related Cortical Potentials Associated with Oral and Facial Functions in Humans

Nakajima¹,

Schunichi²,

Ohba³

et al. 2012

Applications of EMG in Clinical and Sports Medicine

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“…IU, therefore, may be an important factor in explaining why humans differ so much in their response to pain. Specifically, IU may play a modulating role in situations where uncertainty prevails, especially when uncertainty regarding the timing of painful events abounds [14,15]. To indicate the time of onset of the stimulation, and its predictability or non-predictability, many types of cueing designs can be used, such as sound cueing and visual cueing [11,14,16].…”

Section: Introductionmentioning

confidence: 99%

“…To indicate the time of onset of the stimulation, and its predictability or non-predictability, many types of cueing designs can be used, such as sound cueing and visual cueing [11,14,16]. Both variations (predictability and length of the delay before the shock) have shown their influence on pain perception [14,15,17]. Indeed, recent studies confirm that when the timing of pain cannot be fully predicted, some react quite poorly and report increased pain [14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Both variations (predictability and length of the delay before the shock) have shown their influence on pain perception [14,15,17]. Indeed, recent studies confirm that when the timing of pain cannot be fully predicted, some react quite poorly and report increased pain [14,15]. To this day, there is no consensus on the best way to create an unpredictable environment in experimental settings.…”

Section: Introductionmentioning

confidence: 99%

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Unpredictable pain timings lead to greater pain when people are highly intolerant of uncertainty

Bélanger

Morin

Brousseau

et al. 2017

Scandinavian Journal of Pain

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AbstractBackground and purposeMany psychological factors are known to influence pain perception. Among them, intolerance of uncertainty (IU) may play a key modulating role in situations where uncertainty prevails, especially uncertainty regarding the timing of painful events. The objective of this study was to explore the impact of individual differences in IUon pain perception during predictable and unpredictable stimulation timings. We hypothesized that people with high IU, as opposed to those with low IU, would perceive more pain when the timing of painful stimulations cannot be predicted, as compared to when they can.MethodsTwenty (20) healthy adults, aged between 18 and 35 years old, were recruited. Painful sensations were provoked using transcutaneous electrical stimulations of the right sural nerve. By measuring IU (Intolerance of Uncertainty Scale) and subjective pain (verbal numerical rating scale), it was possible to test the relationship between IU and pain perception, by simulating predictable and unpredictable painful experiences. This was done through cued shock interval (CSI) blocks, with either variable timing or fixed timings (long or short time frame). Self-administered questionnaires were also used to measure pain hypervigilance, pain catastrophizing, state anxiety, and trait anxiety.ResultsPearson correlations confirmed the presence of an association (r = 0.63) between IU and the change in pain intensity provoked by unpredictable stimulation timings. Importantly, this association was significant only for stimulations provided at long CSIs, indicating that higher IU scores predicted higher pain intensity scores when stimulation timings became unpredictable, and when the cued delay was long. No association was found between pain scores and other psychological variables.ConclusionsOur results show that IU moderately correlates to the change in pain intensity provoked by unpredictable stimulation timings. High IU scores were associated with a worsening of the subjective pain experience, especially during long delays in an unpredictable situation. These observations suggest that IU could be considered as a psychological variable that is able to influence pain perception in certain situations.ImplicationsAssessing and addressing IU could be an added value in pain-related therapy, especially in chronic pain.

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Predictability of Painful Stimulation Modulates Subjective and Physiological Responses

Cited by 52 publications

References 47 publications

Social Pain and the Brain: Controversies, Questions, and Where to Go from Here

Social Pain and the Brain: Controversies, Questions, and Where to Go from Here

Movement-Related Cortical Potentials Associated with Oral and Facial Functions in Humans

Unpredictable pain timings lead to greater pain when people are highly intolerant of uncertainty

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