This work examines the impact of El Niño-Southern Oscillation (ENSO) on the prediction skill of North Pacific variability (NPV) in retrospective predictions of the NCEP Climate Forecast System, version 2. It is noted that the phase relationship between ENSO and NPV at initial conditions (ICs) affects the prediction skill of NPV. For average lead times of 0-6 months, the prediction skills of sea surface temperature anomalies (SSTAs) in NPV (defined as the NPV index) increase from 0.42 to 0.63 from the cases of an out-of-phase relation between the Niño-3.4 and NPV indices in ICs to the cases of an in-phase relation. It is suggested that when ENSO and NPV are in phase in ICs, ENSO plays a constructive role in the NPV development and enhances its signals. Nevertheless, when ENSO and NPV are out of phase, some pronounced positive NPV events are still predictable. In these cases, the North Pacific is dominated by strong positive SSTAs, which may overcome the opposing influence from the tropical Pacific and display predictability.