Predicted 25(OH)D Score and Colorectal Cancer Risk According to Vitamin D Receptor Expression

Jung, Seungyoun; Qian, Zhi Rong; Yamauchi, Mai; Bertrand, Kimberly A.; Fitzgerald, Kathryn C.; Inamura, Kentaro; Kim, Sun A.; Mima, Kosuke; Sukawa, Yasutaka; Zhang, Xuehong; Wang, Molin; Smith‐Warner, Stephanie A.; Wu, Kana; Fuchs, Charles S.; Chan, Andrew T.; Giovannucci, Edward; Ng, Kimmie; Cho, Eunyoung; Ogino, Shuji; Nishihara, Reiko

doi:10.1158/1055-9965.epi-14-0229

Cited by 25 publications

(22 citation statements)

References 59 publications

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“…(28–30) Table 6 shows a summary of studies that evaluated the association of circulating levels of vitamin D and risk of CRC. (24) , (13) ,(11, 12, 31) The pooled relative risk (RR) of CRC for the highest versus lowest categories of 25(OH)D was 0.67 (95% CI, 0.54 to 0.80). (13) A 10 ng/mL increase in 25(OH)D value was associated with a RR of 0.74 (95% CI, 0.63 to 0.89).…”

Section: Discussionmentioning

confidence: 99%

“…(7) Epidemiology studies of vitamin D intake and predicted vitamin D plasma status have been fairly consistent in suggesting an association between higher vitamin D and reduced colorectal cancer risk, 10 ,(8) but limited data exist on women. (9) (10) (11) (12) A recent observational study meta-analysis reported a 26% lower risk of colorectal cancer per 10 ng/mL increment in blood 25(OH)D levels. (13) Vitamin D supplementation randomized control trials have not been supportive of an association between vitamin D and colorectal cancer, but this lack of association may be influenced by the dose of vitamin D used or the duration of the intervention.…”

Section: Introductionmentioning

confidence: 99%

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Circulating Vitamin D Levels and Risk of Colorectal Cancer in Women

Chandler

Buring

Manson

et al. 2015

Cancer Prevention Research

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Observational data on the association between circulating 25(OH)D and colorectal cancer risk are limited in women. To determine whether prediagnostic levels of 25(OH)D were associated with risk of incident colorectal cancer in the Women’s Health Study (WHS), we conducted a nested case-control study using 274 colorectal cases and 274 controls. Each case was matched to a control by age, ethnicity, fasting status at the time of blood collection, time of day when blood was drawn, and month of blood draw. Conditional logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for colorectal cancer by 25(OH)D quartiles. Mean plasma 25(OH)D was lower in cases versus controls (21.9 vs 23.9 ng/mL, p=0.01). In multivariable-adjusted logistic regression models, plasma 25(OH)D was significantly and inversely associated with odds of colorectal cancer (quartile 4 [Q4] versus quartile 1 [Q1]: OR (95% CI): 0.45 (0.25–0.81), ptrend 0.02). Additionally, we observed a somewhat lower risk of colorectal cancer mortality after adjustment for matching variables, randomization treatment and other risk factors (Q4:Q1 OR[95%CI]: 0.40(0.17–0.97); ptrend 0.05). In this cohort of healthy women, we found a significant inverse association between prediagnostic 25(OH)D levels and risk of incident colorectal cancer, and a borderline significant inverse association between prediagnostic 25(OH)D levels and colorectal cancer mortality. These results support a possible association between plasma 25(OH)D and risk of colorectal cancer in women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating Vitamin D Levels and Risk of Colorectal Cancer in Women

Chandler

Buring

Manson

et al. 2015

Cancer Prevention Research

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“…The association with disease incidence and latitude is not unique to IBD; there is supporting parallel evidence of a north-south gradient in the incidence of other autoimmune and gastrointestinal diseases, including rheumatoid arthritis (34) and colorectal cancer (35)(36)(37) . For colorectal cancer, geographic region (37) , predicted (38) and measured pre-diagnostic circulating 25(OH)D have been linked with disease risk (36) .…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

“…Clearly, more mechanistic studies are needed to identify and confirm the mechanism by which vitamin may exert anti-inflammation effects in CD. (36)(37)(38)70) . Ananthakrishnan et al (71) , recently reported an increased risk of colorectal cancer in a cohort (n 2809) of patients with IBD who were vitamin D deficient (25(0H)D <50 nmol/l).…”

Section: Vitamin D Status and Associations With Disease Severity In Cmentioning

confidence: 99%

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

O’Sullivan

2014

Proc. Nutr. Soc.

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There is increasing scientific interest in the field of vitamin D research, moving the focus beyond bone health to other disease processes. Low circulating vitamin D levels have been reported as a risk factor for several pathophysiologically divergent diseases, including cancers, diabetes, CVD, multiple sclerosis and inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease (IBD). But, therein, remains the challenge: can any single nutrient contribute to multiple complex disease mechanisms and, ultimately, have therapeutic potential? The aim of this review is to critically evaluate several strands of scientific evidence surrounding vitamin D and inflammation, primarily focusing on IBD. Epidemiological studies suggest an increased incidence of IBD and rheumatoid arthritis in countries of more northern latitudes, mirroring sunlight patterns. A considerable body of evidence supports the anti-inflammatory effects of vitamin D, at least in animal models of IBD. Although it is accepted that suboptimal vitamin D status is common in IBD, some studies suggest that this associates with more severe disease. With regard to treatment, the data are only beginning to emerge from randomised controlled trials to suggest that people with IBD may remain in remission longer when treated with oral vitamin D. In conclusion, several strands of evidence suggest that vitamin D may modify the immune response in IBD. There is a continued need for large well-designed clinical trials and mechanistic studies to determine if, and how, this emerging promise translates into tangible clinical benefits for people with chronic debilitating diseases such as IBD.

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“…For example, in the NHS, NHSII, and the Health Professionals Follow-up Study, we developed a model to predict plasma 25-hydroxyvitamin D [25(OH)D] in which the r 2 for each cohort ranged from 0.25 to 0.33, generally consistent with the r 2 from 25(OH)D prediction models derived in other studies. [28–30] Though these models explained only a proportion of the variability in 25(OH)D, predicted 25(OH)D has been inversely associated with several chronic diseases including colorectal cancer,[31] renal cell cancer,[32] and type 2 diabetes[29] among others, highlighting the utility of biomarker prediction models.…”

Section: Discussionmentioning

confidence: 99%

Percent mammographic density prediction: development of a model in the nurses’ health studies

Rice

Rosner

Tamimi

2017

Cancer Causes Control

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Purpose To develop a model to predict percent mammographic density (MD) using questionnaire data and mammograms from controls in the Nurses’ Health Studies’ nested breast cancer case-control studies. Further, we assessed the association between both measured and predicted percent MD and breast cancer risk. Methods Using data from 2955 controls, we assessed several variables as potential predictors. We randomly divided our dataset into a training dataset (two-thirds of the dataset) and a testing dataset (one-third of the dataset). We used stepwise linear regression to identify the subset of variables that were most predictive. Next, we examined the correlation between measured and predicted percent MD in the testing dataset and computed the r2 in the total dataset. We used logistic regression to examine the association between measured and predicted percent MD and breast cancer risk. Results In the training dataset, several variables were selected for inclusion, including age, body mass index, and parity, among others. In the testing dataset, the Spearman correlation coefficient between predicted and measured percent MD was 0.61. As the prediction model performed well in the testing dataset, we developed the final model in the total dataset. The final prediction model explained 41% of the variability in percent MD. Both measured and predicted percent MD were similarly associated with breast cancer risk adjusting for age, menopausal status, and hormone use (OR per 5 unit increase=1.09 for both). Conclusion These results suggest that predicted percent MD may be useful for research studies in which mammograms are unavailable.

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Predicted 25(OH)D Score and Colorectal Cancer Risk According to Vitamin D Receptor Expression

Cited by 25 publications

References 59 publications

Circulating Vitamin D Levels and Risk of Colorectal Cancer in Women

Circulating Vitamin D Levels and Risk of Colorectal Cancer in Women

Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?

Percent mammographic density prediction: development of a model in the nurses’ health studies

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