Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

Schrems, W.; Schrems-Hoesl, Laura M.; Bendschneider, D; Mardin, Christian Y.; Laemmer, Robert; Kruse, Friedrich E.; Horn, Folkert K.

doi:10.1001/jamaophthalmol.2015.2427

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…This is likely due to the larger standard deviations of the pRNFL measurements compared to the RNFL measurements. Although this shows that there is substantial spread of pRNFL thickness between subjects, it is known that the reproducibility of pRNFL measurements within the same subject over time is excellent [37][38][39]. Therefore, pRNFL measurements can be valuable for measuring disease progression in individual patients over time.…”

Section: Discussionmentioning

confidence: 96%

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy

et al. 2019

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Background Progressive myelopathy is the main cause of disability in adrenoleukodystrophy (ALD). Development of therapies is hampered by a lack of quantitative outcome measures. In this study, we investigated whether myelopathy in ALD is associated with retinal neurodegeneration on optical coherence tomography (OCT), which could serve as a surrogate outcome measure. Methods Sixty-two patients (29 men and 33 women) and 70 age-matched and sex-matched controls (33 men and 37 women) were included in this cross-sectional study. We compared retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (pRNFL) thickness between ALD patients and controls. In addition, we correlated these OCT measurements with clinical parameters of severity of myelopathy. Results Patients had significantly thinner RNFL (male group, p < 0.05) and pRNFL superior and temporal quadrant [both male (p < 0.005) and female (p < 0.05) groups] compared to controls. Comparing three groups (symptomatic patients, asymptomatic patients and controls), there were significant differences in RNFL thickness (total grid and peripheral ring) in the male group (p ≤ 0.002) and in pRNFL thickness (superior and temporal quadrant) in both male (p ≤ 0.02) and the female (p ≤ 0.02) groups. Neuroretinal layer thickness correlated moderately with severity of myelopathy in men (correlation coefficients between 0.29-0.55, p < 0.02), but not in women. Conclusions These results suggest that neurodegeneration of the spinal cord in ALD is reflected in the retina of patients with ALD. Therefore, OCT could be valuable as an outcome measure for the myelopathy of ALD. Additional longitudinal studies are ongoing.

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Section: Discussionmentioning

confidence: 96%

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy

et al. 2019

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“…First, as different OCT devices (stratus, cirrus, 3D, or Optovue OCT) were used in the studies included in this meta-analysis to measure the RNFL thickness, we cannot ensure the homogeneity of inspection results. Although the prediction of mean pRNFL thickness values by equations derived from time domain OCT and spectral domain OCT can be conducted with high levels of agreement, [31] the mean RNFL in normal patient is around 105.1 (± 9.5) μm [32] and the resolution is of few micrometers depending on the device. When the retina was affected by OSAS, high prediction errors may occur.…”

Section: Discussionmentioning

confidence: 99%

Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome

et al. 2016

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Objective:To investigate the changes of retinal nerve fiber layer (RNFL) thickness in obstructive sleep apnea syndrome (OSAS) patients.Methods:Relevant studies were selected from 3 major literature databases (PubMed, Cochrane Library, and EMBASE) without language restriction. Main inclusion criteria is that a case-control study in which RNFL thickness was measured by a commercial available optical coherence tomography (OCT) in OSAS patients. Meta-analysis was performed using STATA 12.0 software. Efficacy estimates were evaluated by weighted mean difference with corresponding 95% confidence intervals (CIs). Primary outcome evaluations were: the average changes of RNFL thickness in total OSAS patients, subgroup analysis of RNFL thickness changes in patients of different OSAS stages, and subgroup analysis of 4-quadrant RNFL thickness changes in total OSAS patients.Results:Of the initial 327 literatures, 8 case-control studies with 763 eyes of OSA patients and 474 eyes of healthy controls were included (NOS scores ≥6). For the people of total OSAS, there had an average 2.92 μm decreased RNFL thickness compared with controls (95% CI: −4.61 to −1.24, P = 0.001). For subgroup analysis of OSAS in different stages, the average changes of RNFL thickness in mild, moderate, severe, and moderate to severe OSAS were 2.05 (95% CI: −4.40 to 0.30, P = 0.088), 2.32 (95% CI: −5.04 to 0.40, P = 0.094), 4.21 (95% CI: −8.36 to −0.06, P = 0.047), and 4.02 (95% CI: −7.65 to −0.40, P = 0.03), respectively. For subgroup analysis of 4-quadrant, the average changes of RNFL thickness in Superior, Nasal, Inferior, and Temporal quadrant were 2.43 (95% CI: −4.28 to −0.57, P = 0.01), 1.41 (95% CI: −3.33 to 0.51, P = 0.151), 3.75 (95% CI: −6.92 to −0.59, P = 0.02), and 0.98 (95% CI: −2.49 to 0.53, P = 0.203), respectively.Conclusion:Our study suggests that RNFL thickness in OSAS patients is much thinner than healthy population, especially in superior and inferior quadrant. The impact of OSAS disease on RNFL and visual function should be taken seriously in the further study.

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“…[ 37 ] In addition, RNFL measured by SD-OCT may be more relevant to migraine than TD-OCT., for the SD-OCT can detect more subtle damage to RNFL. [ 38 ]…”

Section: Discussionmentioning

confidence: 99%

Retinal nerve fiber layer changes in migraine

Lin

Yi²,

Zhang

et al. 2020

Medicine

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Background: Migraine is a common neurological disease, which seriously affects the quality of life and daily activities of patients. Although migraine is a transient phenomenon of cerebral vasoconstriction, it is well documented that recurrent attacks of migraine may lead to abnormalities in retinal structure. Optical coherence tomography (OCT) is a sensitive method to detect subtle damage in retinal nerve fiber layer (RNFL). There have been many studies investigating the difference in RNFL thickness with optical coherence tomography (OCT) between migraine patients and healthy controls. However, the results were not consistent. Our purpose is to perform a meta-analysis to investigate RNFL alterations in migraine. Methods: We will search PubMed, Embase, Web of science for studies assessing the differences in RNFL measured by OCT between patients with migraine and healthy controls. Case-control studies published in English will be included. Two reviewers will independently screen eligible articles, extract data, and assess quality. This meta-analysis will synthesize selected research data and compare the difference in RNFL thickness between patients with migraine and healthy controls. We will use Stata 15 in this meta-analysis. I 2 statistics will be used to assess heterogeneity. If I 2 ≤ 50%, the data are synthesized will use a fixed effect model. Otherwise, a random effect model will be performed. Publication bias will be determined by the Egger test. The methodological quality of all included studies will be evaluated by the Newcastle-Ottawa Scale (NOS). We will perform subgroup analysis, sensitivity analysis, and meta-regression analysis to test the robustness of the results. Results: We will obtain quantitative results regarding the difference in RNFL thickness between migraine patients and healthy controls. The results will be published in a peer-reviewed journal. Conclusions: The results of this study provide a high-quality synthesis of existing evidence and provide a basis for assessing the effect of migraine on the thickness of RNFL. Registration number: INPLASY 202060033

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Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

Cited by 8 publications

References 29 publications

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy

Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy

Decreased retinal nerve fiber layer thickness in patients with obstructive sleep apnea syndrome

Retinal nerve fiber layer changes in migraine

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