2021
DOI: 10.1016/j.csbj.2021.06.041
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Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

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Cited by 33 publications
(27 citation statements)
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“…The alignments and the amino acid configurations of the corresponding spike protein motifs were subsequently inspected on the structure of the spike protein RBD [3D model generated as previously described ( Beaudoin et al, 2021 )] to determine whether the side chains are found on the surface of the receptor-binding domain. Since the literature on the 3D structure of binding sites for non-RGD motifs is limited and the potential binding modes may be numerous, in order to quantitatively assess motif accessibility, structural flexibility and solvent accessibility were determined to better understand the surrounding residue microenvironment.…”
Section: Structural Orientation Of Potential Integrin-binding Motifsmentioning
confidence: 99%
“…The alignments and the amino acid configurations of the corresponding spike protein motifs were subsequently inspected on the structure of the spike protein RBD [3D model generated as previously described ( Beaudoin et al, 2021 )] to determine whether the side chains are found on the surface of the receptor-binding domain. Since the literature on the 3D structure of binding sites for non-RGD motifs is limited and the potential binding modes may be numerous, in order to quantitatively assess motif accessibility, structural flexibility and solvent accessibility were determined to better understand the surrounding residue microenvironment.…”
Section: Structural Orientation Of Potential Integrin-binding Motifsmentioning
confidence: 99%
“…Structural similarity comparisons have been shown to give insight into potential protein–protein interactions, despite low sequence similarity [ 71 , 72 ]. Using RUPEE [ 73 ], the nsORFs were compared to all known protein families, and HMI-PRED [ 74 ] was used to infer potential host interaction partners.…”
Section: Resultsmentioning
confidence: 99%
“… 80 , 130 Many sequence parts of the RBD of these viruses show similarity both to nonhuman but also human protein motifs, which may help to understand protein–protein interactions with the S-protein more broadly. 131 …”
Section: Evolution Of the S-protein In A Structural Contextmentioning
confidence: 99%