Predicting and Preventing Sudden Cardiac Death

Estes, N.A. Mark

doi:10.1161/circulationaha.110.974170

Cited by 55 publications

(32 citation statements)

References 21 publications

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“…15 Defibrillators in public locations (Table 4), such as train stations, 13 however, only reduce the incidence of SCD when the local population is trained to use them. 72 Recent data from the United States Cardiac Arrest Registry to Enhance Survival (CARES) suggest that rates of survival following out-of-hospital cardiac arrest have improved among sites participating in a performanceimprovement registry. 73 Improved survival rates are more prominent in patients aged 18-80 years.…”

Section: Management Of Cardiac Arrestmentioning

confidence: 99%

A Clinical Perspective on Sudden Cardiac Death

2016

Arrhythmia &Amp; Electrophysiology Review

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This article presents the epidemiology, aetiology and pathophysiology of sudden cardiac death. The modern management of survivors as well as of family members of victims is discussed, as are the relevant recommendations of guidelines prepared by learned societies. KeywordsOut-of-hospital cardiac arrest, sports-related sudden death, sudden cardiac death, sudden unexplained death syndrome Disclosure: The authors have no conflicts of interest to declare.

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Section: Management Of Cardiac Arrestmentioning

confidence: 99%

A Clinical Perspective on Sudden Cardiac Death

2016

Arrhythmia &Amp; Electrophysiology Review

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“…Epidemiological studies suggest that the risk of CA is higher among the aged population (51.1% over 65 years of age) as compared to the young (18.7% younger than 34 years old), with a mean age around 64 years old [4, 8-10]. CA can result from numerous conditions including: ventricular fibrillation, hypertrophic cardiomyopathy, arrhythmias (e.g., long QT syndrome or Wolff-Parkinson-White), coronary abnormalities, aortic rupture, arrhythmogenic right-ventricular cardiomyopathy and myocardial infarctions (artery blockage) [11, 12]. Ventricular fibrillation is the most common cause of CA in the aged population, whereas CA in the young (under 30 years) is commonly experienced during physical activity due to an inherited heart condition [11, 13].…”

Section: Introductionmentioning

confidence: 99%

Global Cerebral Ischemia: Synaptic and Cognitive Dysfunction

Neumann¹,

Cohan²,

Dave³

et al. 2013

Current Drug Targets

111

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Cardiopulmonary arrest is one of the leading causes of death and disability, primarily occurring in the aged population. Numerous global cerebral ischemia animal models induce neuronal damage similar to cardiac arrest. These global cerebral ischemia models range from vessel occlusion to total cessation of cardiac function, both of which have allowed for the investigation of this multifaceted disease and detection of numerous agents that are neuroprotective. Synapses endure a variety of alterations after global cerebral ischemia from the resulting excitotoxicity and have been a major target for neuroprotection; however, neuroprotective agents have proven unsuccessful in clinical trials, as neurological outcomes have not displayed significant improvements in patients. A majority of these neuroprotective agents have specific neuronal targets, where the success of future neuroprotective agents may depend on non-specific targets and numerous cognitive improvements. This review focuses on the different models of global cerebral ischemia, neuronal synaptic alterations, synaptic neuroprotection and behavioral tests that can be used to determine deficits in cognitive function after global cerebral ischemia.

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“…Cardioid: Whole-heart modeling on Blue Gene/Q Introduction Sudden cardiac death (SCD) from cardiac arrest is the most common cause of death worldwide, accounting for more than 50% of all deaths from cardiovascular disease and 250,000 to 300,000 deaths annually in the United States [17]. Though much controversy exists, SCD is generally accepted to result from arrhythmias, predominately ventricular fibrillation, and hence can be considered an electrical dysfunction of the heart.…”

Section: Qbox On Sequoiamentioning

confidence: 99%