Predicting and Treating Post-traumatic Epilepsy

Rubiños, Clio; Waters, Brandon; Hirsch, Lawrence J.

doi:10.1007/s11940-022-00727-2

Cited by 5 publications

(5 citation statements)

References 94 publications

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“…A significant risk factor associated with epileptogenesis following ABI is the occurrence of acute symptomatic seizures (ASyS) (clinical or electrographic). [84][85][86] However, there are additional EEG features that can further stratify riskparticularly EAs, which have been associated with the development of epilepsy following any type of ABI. These patterns are thought to play a role in epileptogenesis by increasing metabolic demand of an area already at risk, leading to secondary brain injury, disruption of cortical connectivity, and hypersynchronization.…”

Section: Eeg As a Predictor Of Long-term Outcome And Recovery Of Cons...mentioning

confidence: 99%

Electroencephalography as a Biomarker of Prognosis in Acute Brain Injury

Rubinos,

Bruzzone,

Viswanathan

et al. 2023

Semin Neurol

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Electroencephalography (EEG) is a noninvasive tool that allows the monitoring of cerebral brain function in critically ill patients, aiding with diagnosis, management, and prognostication. Specific EEG features have shown utility in the prediction of outcomes in critically ill patients with status epilepticus, acute brain injury (ischemic stroke, intracranial hemorrhage, subarachnoid hemorrhage, and traumatic brain injury), anoxic brain injury, and toxic-metabolic encephalopathy. Studies have also found an association between particular EEG patterns and long-term functional and cognitive outcomes as well as prediction of recovery of consciousness following acute brain injury. This review summarizes these findings and demonstrates the value of utilizing EEG findings in the determination of prognosis.

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Section: Eeg As a Predictor Of Long-term Outcome And Recovery Of Cons...mentioning

confidence: 99%

Electroencephalography as a Biomarker of Prognosis in Acute Brain Injury

Rubinos,

Bruzzone,

Viswanathan

et al. 2023

Semin Neurol

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“…If the therapy is ineffective or the patient does not tolerate it well, the doctor must employ an additional medication (monotherapy) or other drug combinations than those that have been previously utilized (add-on therapy). Innovative medicines provide a chance for a life devoid of epileptic seizures [ 91 , 95 ].…”

Section: Pharmacotherapymentioning

confidence: 99%

Unveiling the Multifaceted Problems Associated with Dysrhythmia

Witczyńska,

Alaburda,

Grześk

et al. 2023

IJMS

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Dysrhythmia is a term referring to the occurrence of spontaneous and repetitive changes in potentials with parameters deviating from those considered normal. The term refers to heart anomalies but has a broader meaning. Dysrhythmias may concern the heart, neurological system, digestive system, and sensory organs. Ion currents conducted through ion channels are a universal phenomenon. The occurrence of channel abnormalities will therefore result in disorders with clinical manifestations depending on the affected tissue, but phenomena from other tissues and organs may also manifest themselves. A similar problem concerns the implementation of pharmacotherapy, the mechanism of which is related to the impact on various ion currents. Treatment in this case may cause unfavorable effects on other tissues and organs. Drugs acting through the modulation of ion currents are characterized by relatively low tissue specificity. To assess a therapy’s efficacy and safety, the risk of occurrences in other tissues with similar mechanisms of action must be considered. In the present review, the focus is shifted prominently onto a comparison of abnormal electrical activity within different tissues and organs. This review includes an overview of the types of dysrhythmias and the basic techniques of clinical examination of electrophysiological disorders. It also presents a concise overview of the available pharmacotherapy in particular diseases. In addition, the authors review the relevant ion channels and their research technique based on patch clumping.

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“…Retrospective case-controlled studies suggest some of these quantitative EEG features hold promise as predictive indicators for PTE [4][5][6][7] . However, these patients studies are face limitions such as poorly controlled environments, bias toward severe injury in participant selection, and insufficient consideration of patients' genetics, demographic information, comorbid conditions, or medication history 8 . Though animal models offer greater control over environmental variability, early animal studies of TBI commonly use rodent models with fixed genetic backgrounds, failing to capture the genetic diversity seen in humans 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice

Shannon,

Levine,

Dirickson

et al. 2024

Preprint

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Oscillations, a highly conserved brain function across mammalian species, are pivotal in brain physiology and pathology. Traumatic brain injury (TBI) often leads to subacute and chronic brain oscillatory alterations associated with complications like post-traumatic epilepsy (PTE) in patients and animal models. Our recent work longitudinally recorded local field potential from the contralateral hippocampus of 12 strains of recombinant inbred Collaborative Cross (CC) mice alongside classical laboratory inbred C57BL/6J mice after lateral fluid percussion injury. In this study, we profiled the acute (<12 hr post-injury) and subacute (12-48 hr post-injury) hippocampal oscillatory responses to TBI and evaluated their predictive value for PTE. We found dynamic high-amplitude rhythmic spikes with elevated power density and reduced entropy that prevailed during the acute phase in CC031 mice who later developed PTE. This characteristic early brain oscillatory alteration is absent in CC031 sham controls or other CC and reference C57BL/6J strains that did not develop PTE after TBI. Our work provides quantitative measures linking early brain oscillation to PTE at a population level in mice under controlled experimental conditions. These findings will offer insights into circuit mechanisms and potential targets for neuromodulatory intervention.

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Predicting and Treating Post-traumatic Epilepsy

Cited by 5 publications

References 94 publications

Electroencephalography as a Biomarker of Prognosis in Acute Brain Injury

Electroencephalography as a Biomarker of Prognosis in Acute Brain Injury

Unveiling the Multifaceted Problems Associated with Dysrhythmia

Early hippocampal high-amplitude rhythmic spikes predict post-traumatic epilepsy in mice

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