Predicting aquatic development and mortality rates of Aedes aegypti

Zapletal, Josef; Gupta, Himanshu; Erraguntla, Madhav; Adelman, Zach N.; Myles, K.M.; Lawley, Mark

doi:10.1371/journal.pone.0217199

Cited by 4 publications

(2 citation statements)

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“…Studies across the literature have used different validation strategies such as random sampling [ 20 , 65 - 67 ], time-based splitting [ 4 , 5 , 67 - 69 ], patient-specific splitting [ 6 , 32 , 53 , 70 , 71 ], or a combination of these methods to estimate predictive model performance. Simple random sampling–based cross-validation [ 72 , 73 ] may not fully address the generalizability aspect of the model to new patients and new time periods. Some studies [ 6 ] using a patient-based validation strategy used a part of their test data for tuning model parameters, which affected the validity of the performance estimation.…”

Section: Discussionmentioning

confidence: 99%

Improved Low-Glucose Predictive Alerts Based on Sustained Hypoglycemia: Model Development and Validation Study

et al. 2021

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Background Predictive alerts for impending hypoglycemic events enable persons with type 1 diabetes to take preventive actions and avoid serious consequences. Objective This study aimed to develop a prediction model for hypoglycemic events with a low false alert rate, high sensitivity and specificity, and good generalizability to new patients and time periods. Methods Performance improvement by focusing on sustained hypoglycemic events, defined as glucose values less than 70 mg/dL for at least 15 minutes, was explored. Two different modeling approaches were considered: (1) a classification-based method to directly predict sustained hypoglycemic events, and (2) a regression-based prediction of glucose at multiple time points in the prediction horizon and subsequent inference of sustained hypoglycemia. To address the generalizability and robustness of the model, two different validation mechanisms were considered: (1) patient-based validation (model performance was evaluated on new patients), and (2) time-based validation (model performance was evaluated on new time periods). Results This study utilized data from 110 patients over 30-90 days comprising 1.6 million continuous glucose monitoring values under normal living conditions. The model accurately predicted sustained events with >97% sensitivity and specificity for both 30- and 60-minute prediction horizons. The false alert rate was kept to <25%. The results were consistent across patient- and time-based validation strategies. Conclusions Providing alerts focused on sustained events instead of all hypoglycemic events reduces the false alert rate and improves sensitivity and specificity. It also results in models that have better generalizability to new patients and time periods.

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Section: Discussionmentioning

confidence: 99%

Improved Low-Glucose Predictive Alerts Based on Sustained Hypoglycemia: Model Development and Validation Study

et al. 2021

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“…The availability of big data in the healthcare sector has made machine learning (ML) a viable instrument for disease prediction [15–18]. In contrast to traditional diagnostic techniques employing population based statistics, ML methods develop models that are trained using large amounts of data.…”

Section: Introductionmentioning

confidence: 99%

Predicting long-term type 2 diabetes with support vector machine using oral glucose tolerance test

et al. 2019

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Diabetes is a large healthcare burden worldwide. There is substantial evidence that lifestyle modifications and drug intervention can prevent diabetes, therefore, an early identification of high risk individuals is important to design targeted prevention strategies. In this paper, we present an automatic tool that uses machine learning techniques to predict the development of type 2 diabetes mellitus (T2DM). Data generated from an oral glucose tolerance test (OGTT) was used to develop a predictive model based on the support vector machine (SVM). We trained and validated the models using the OGTT and demographic data of 1,492 healthy individuals collected during the San Antonio Heart Study. This study collected plasma glucose and insulin concentrations before glucose intake and at three time-points thereafter (30, 60 and 120 min). Furthermore, personal information such as age, ethnicity and body-mass index was also a part of the data-set. Using 11 OGTT measurements, we have deduced 61 features, which are then assigned a rank and the top ten features are shortlisted using minimum redundancy maximum relevance feature selection algorithm. All possible combinations of the 10 best ranked features were used to generate SVM based prediction models. This research shows that an individual’s plasma glucose levels, and the information derived therefrom have the strongest predictive performance for the future development of T2DM. Significantly, insulin and demographic features do not provide additional performance improvement for diabetes prediction. The results of this work identify the parsimonious clinical data needed to be collected for an efficient prediction of T2DM. Our approach shows an average accuracy of 96.80% and a sensitivity of 80.09% obtained on a holdout set.

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Predictive model for microclimatic temperature and its use in mosquito population modeling

Erraguntla

Dave

Zapletal

et al. 2021

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Mosquitoes transmit several infectious diseases that pose significant threat to human health. Temperature along with other environmental factors at breeding and resting locations play a role in the organismal development and abundance of mosquitoes. Accurate analysis of mosquito population dynamics requires information on microclimatic conditions at breeding and resting locations. In this study, we develop a regression model to characterize microclimatic temperature based on ambient environmental conditions. Data were collected by placing sensor loggers at resting and breeding locations such as storm drains across Houston, TX. Corresponding weather data was obtained from National Oceanic and Atmospheric Administration website. Features extracted from these data sources along with contextual information on location were used to develop a Generalized Linear Model for predicting microclimate temperatures. We also analyzed mosquito population dynamics for Aedes albopictus under ambient and microclimatic conditions using system dynamic (SD) modelling to demonstrate the need for accurate microclimatic temperatures in population models. The microclimate prediction model had an R2 value of ~ 95% and average prediction error of ~ 1.5 °C indicating that microclimate temperatures can be reliably estimated from the ambient environmental conditions. SD model analysis indicates that some microclimates in Texas could result in larger populations of juvenile and adult Aedes albopictus mosquitoes surviving the winter without requiring dormancy.

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Predicting aquatic development and mortality rates of Aedes aegypti

Cited by 4 publications

References 40 publications

Improved Low-Glucose Predictive Alerts Based on Sustained Hypoglycemia: Model Development and Validation Study

Improved Low-Glucose Predictive Alerts Based on Sustained Hypoglycemia: Model Development and Validation Study

Predicting long-term type 2 diabetes with support vector machine using oral glucose tolerance test

Predictive model for microclimatic temperature and its use in mosquito population modeling

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