Predicting Autism Spectrum Disorder in Young Children: The Predictive Utility of the Ghuman-Folstein Screen for Social Interaction and Sociodemographic Factors

Princiotta, Dana; Skoch, Sarah Hamill; Phelps, Randi A.; Morris, Richard J.; Breitborde, Nicholas J. K.; Bukelis, Irena; Grados, Marco A.; Ghuman, Jaswinder K.

doi:10.4236/psych.2020.117069

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…Our measure of risk of ASD in this study, the SSI-T [23,24], is a relatively recently developed screener of ASD among pre-school children and is not as widely used as some other measures, which may make it di cult to compare the results of our study to other studies that may have used more widely known screening tools. However, studies using the SSI have reported the measure reliably discriminates children diagnosed with ASD from children with other developmental or psychiatric conditions [25,49]. Since the SSI primarily focuses on social interaction skills, the impact on language ability is minimized, making it a valuable screening tool for capturing a wide range of symptom presentations [49].…”

Section: Study Strengths and Limitationsmentioning

confidence: 99%

“…At the 36-month postpartum data collection stage women completed the Screen for Social Interaction -Toddler Version (SSI-T), in reference to their rst-born child [23]. This is a 26-item inventory which was developed to screen for autism spectrum disorder in children aged 24-42 months old [24] and has been found to have predictive utility [25]. This instrument asks questions such as "When you talk with your child, does s/he look at you?…”

Section: Introductionmentioning

confidence: 99%

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The association between prenatal psychosocial factors and autism spectrum disorder in offspring at 3 years: a prospective cohort study

Seebeck

Sznajder

Kjerulff

2023

Soc Psychiatry Psychiatr Epidemiol

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Few studies of risk factors for autism spectrum disorder (ASD) have been prospective in design or investigated the role of psychosocial factors measured during pregnancy. We aimed to investigate associations between prenatal psychosocial factors -including stress, social-support, depression, and trouble paying for basic needs -and risk of ASD in offspring, as part of a multicenter prospective cohort study of more than 2,000 mother-child pairs. MethodsNulliparous women aged 18-35 years, living in Pennsylvania, USA, were interviewed during pregnancy and multiple times postpartum over the course of a 3-year period. There were 2,388 participants who completed the Screen for Social Interaction Toddler Version (SSI-T), a measure of risk of ASD, when their child was 36 months old. We investigated the association between a variety of adverse psychosocial factors experienced during pregnancy and risk of ASD in offspring at the age of 3-years, controlling for relevant confounding variables. ResultsThere were 102 children (4.3%) who scored as at risk of ASD at 3-years. Based on multivariable logistic regression, prenatal psychosocial factors that were signi cantly associated with risk of ASD were low social-support and trouble paying for basic needs. Other factors associated with risk of ASD were low maternal education, maternal use of antibiotics and antidepressants during pregnancy, and having a male child. None of the pregnancy or delivery complications were associated with risk of ASD. ConclusionThese ndings suggest that maternal experience of adverse psychosocial factors during pregnancy may be important intrauterine exposures related to the pathogenesis of ASD. age of 3-years, controlling for relevant confounding factors, such as prenatal and perinatal complications, and maternal use of antidepressants and other medications during pregnancy. Methods Participants and ProcedureThis is a secondary analysis using data from the First Baby Study (FBS). The FBS was a prospective cohort study designed to assess the association between mode of delivery and subsequent fecundity and fertility over the course of three years after rst childbirth. The sample size and power calculations, participant ow chart and sample representativeness have been described previously [15, 16]. A planned secondary analysis was to investigate the association between prenatal and perinatal factors and child development, measured at 3-years. Women were recruited from childbirth education courses, hospital tours, low-income clinics, private obstetric practices and newspaper advertisements throughout the state. Inclusion criteria were aged 18 to 35, nulliparous, singleton pregnancy, planning to deliver in Pennsylvania, and English or Spanish speaking. Exclusion criteria were: a prior pregnancy of 20 weeks gestation or longer, a prior cesarean section, a surrogate pregnancy, planning for the child to be adopted, planning to deliver at home or in a birthing center not associated with a hospital, and delivering before 34 weeks gestation. Sample representati...

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Section: Study Strengths and Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between prenatal psychosocial factors and autism spectrum disorder in offspring at 3 years: a prospective cohort study

Seebeck

Sznajder

Kjerulff

2023

Soc Psychiatry Psychiatr Epidemiol

View full text Add to dashboard Cite

show abstract

Low social-support and trouble paying for basic needs during pregnancy are associated with increased risk of autism spectrum disorder in offspring at 3-years: A prospective cohort study

Seebeck

Sznajder

Kjerulff

2022

Preprint

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Purpose Few studies of risk factors for autism spectrum disorder (ASD) have been prospective in design or investigated the role of psychosocial factors measured during pregnancy. We aimed to investigate associations between prenatal psychosocial factors - including stress, social-support, depression, and trouble paying for basic needs - and risk of ASD in offspring, as part of a multicenter prospective cohort study of more than 2,000 mother-child pairs. Methods Nulliparous women aged 18–35 years, living in Pennsylvania, USA, were interviewed during pregnancy and multiple times postpartum over the course of a 3-year period. There were 2,388 participants who completed the Screen for Social Interaction Toddler Version (SSI-T), a measure of risk of ASD, when their child was 36 months old. We investigated the association between a variety of adverse psychosocial factors experienced during pregnancy and risk of ASD in offspring at the age of 3-years, controlling for relevant confounding variables. Results There were 102 children (4.3%) who scored as at risk of ASD at 3-years. Based on multivariable logistic regression, prenatal psychosocial factors that were significantly associated with risk of ASD were low social-support and trouble paying for basic needs. Other factors associated with risk of ASD were low maternal education, maternal use of antibiotics and antidepressants during pregnancy, and having a male child. None of the pregnancy or delivery complications were associated with risk of ASD. Conclusion These findings suggest that maternal experience of adverse psychosocial factors during pregnancy may be important intrauterine exposures related to the pathogenesis of ASD.

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Predicting Autism Spectrum Disorder in Young Children: The Predictive Utility of the Ghuman-Folstein Screen for Social Interaction and Sociodemographic Factors

Cited by 2 publications

References 27 publications

The association between prenatal psychosocial factors and autism spectrum disorder in offspring at 3 years: a prospective cohort study

The association between prenatal psychosocial factors and autism spectrum disorder in offspring at 3 years: a prospective cohort study

Low social-support and trouble paying for basic needs during pregnancy are associated with increased risk of autism spectrum disorder in offspring at 3-years: A prospective cohort study

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