Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm

Sun, Xianzhong; Elston, Robert C.; Barnholtz‐Sloan, Jill S.; Falk, Gary W.; Grady, William M.; Faulx, Ashley L.; Mittal, Sumeet K.; Canto, Marcia Irene; Shaheen, Nicholas J.; Wang, Jean S.; Iyer, Prasad G.; Abrams, Julian A.; Tian, Ye D.; Willis, Joseph E.; Guda, Kishore; Markowitz, Sanford D.; Chandar, Apoorva K.; Warfe, James M.; Brock, Wendy; Chak, Amitabh

doi:10.1158/1055-9965.epi-15-0832

Cited by 12 publications

(11 citation statements)

References 28 publications

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“…In future, the mutation could be incorporated into a risk prediction model, such as the BE Translational Research Network model, which combines family history and clinical risk factors to identify individuals at high risk for BE. 30…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The Epidemiology of Esophageal Adenocarcinoma

2018

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The incidence of esophageal adenocarcinoma (EAC) has increased in many Western countries and is higher in men than women. Some risk factors for EAC have been identified-mainly gastroesophageal reflux disease, Barrett's esophagus, obesity, and tobacco smoking. It is not clear whether interventions to address these factors can reduce risk of EAC, although some evidence exists for smoking cessation. Although consumption of alcohol is not associated with EAC risk, other exposures, such as physical activity, nutrition, and medication use, require further study. Genetic variants have been associated with risk for EAC, but their overall contribution is low. Studies are needed to investigate associations between risk factors and the molecular subtypes of EAC. The prognosis for patients with EAC has slightly improved, but remains poor-screening and surveillance trials of high-risk individuals are needed.

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Section: Accepted Manuscriptmentioning

confidence: 99%

The Epidemiology of Esophageal Adenocarcinoma

2018

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“…These models tend to have fair performance in predicting the likelihood that a subject will have Barrett’s esophagus. A recent study aimed to combine these with familial history [ 9 ]. Based on close to 900 Barrett’s cases, the authors developed a model using eight risk factors including age, sex, smoking, heartburn frequency, and use of acid suppressants.…”

Section: Epidemiology Of Barrett’s Esophagusmentioning

confidence: 99%

Natural History of Barrett’s Esophagus

Kuipers

Spaander

2018

Dig Dis Sci

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Barrett’s esophagus (BE) is a very common condition. We have obtained fairly profound knowledge of the natural history of this condition. This results from many cross-sectional and cohort studies, many describing patients undergoing long-term surveillance. Their consent to use their clinical data has improved our knowledge to the benefit of these same and other patients. The prevalence of BE increases with age both in men and in women. This increase starts at a younger age in men than in women. The incidence of high-grade dysplasia and cancer in BE depends on segment length, gender, and age. The latter two likely indicate the duration of the presence of BE in an individual patient. Other factors that influence the incidence of dysplasia and cancer are smoking behavior and use of certain medications such as PPIs, statins, and NSAIDs. Surveillance of BE and treatment of dysplasia can impact the incidence of and mortality due to esophageal adenocarcinoma. This is of major benefit to a subgroup of BE patients. The epidemiology and burden of disease ask for further efforts to develop targeted screening, surveillance, and intervention techniques in coming years.

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“…The extent to which BE or EA (including adenocarcinoma of the gastroesophageal junction) in siblings determines risk of BE or EA was examined using a training set data of 879 BE pedigrees and a validation set of data from 643 pedigrees, obtained from the Barrett’s Esophagus Translational Research Network 26 . In male and female individuals, having a sibling with BE or EA associated with increased risk.…”

Section: Germline Variations and Susceptibilitymentioning

confidence: 99%

The Evolving Genomic Landscape of Barrett’s Esophagus and Esophageal Adenocarcinoma

et al. 2017

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We have recently gained unprecedented insight into genetic factors that determine risk for Barrett’s esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of tumorigenesis that challenge the current multi-step model of progression to EA. Newer, cost-effective technologies create opportunities to rapidly translate the analysis of DNA into tools that can identify patients with BE at high risk for cancer, detect dysplastic lesions at earlier stages, and uncover mechanisms of carcinogenesis.

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Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm

Cited by 12 publications

References 28 publications

The Epidemiology of Esophageal Adenocarcinoma

The Epidemiology of Esophageal Adenocarcinoma

Natural History of Barrett’s Esophagus

The Evolving Genomic Landscape of Barrett’s Esophagus and Esophageal Adenocarcinoma

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