Predicting bioaccumulation potential: A test of a fugacity-based model

Ferraro, Steven P.; Lee, Henry; Ozretich, Robert J.; Specht, David T.

doi:10.1007/bf01054983

Cited by 52 publications

(43 citation statements)

References 29 publications

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“…An additional study by Drouillard et al (2008) For N. virens, the 28-d and steady-state BSAFs were similar among congeners and between the Arthur Kill and Newark Bay sediment exposures ( Figure 16). The BSAFs obtained in this study were lower overall compared to previously reported values (0.19-1.41) (Pruell et al 1993 Ferraro et al 1990Ferraro et al , 1991Brannon et al 1993;Pruell et al 1993;Boese et al 1995Boese et al , 1996. Overall, the BSAFs obtained in this study for M. nasuta were lower compared to previously reported values.…”

Section: Polychlorinated Biphenyls (Pcbs)contrasting

confidence: 87%

“…The BSAF values were substantially lower for the Arthur Kill sediment except for fluoranthene (Table C4; Figure 26), consistent with similar data determined for PCBs. The BSAF values determined for the Newark Bay site were similar to values reported by Ferraro et al (1990).…”

Section: Polycyclic Aromatic Hydrocarbons (Pahs)supporting

confidence: 86%

“…The steady-state BSAFs determined in this study fell within the range of 0.118 to 0.479 for p,p-DDTs reported for N. virens (Metcalf and Eddy, Inc. 1995). BASF values for M. nasuta exposed to field-contaminated sediment reported by Ferraro et al (1990) and Boese et al (1997) were typically higher than values determined for the Arthur Kill sediment. Boese et al (1997) reported that the M. nasuta BSAF for p,p-DDT (0.09) was lower than DDDs and DDEs (0.72 -1.67), a finding corroborated by this study.…”

Section: Chlorinated Pesticidescontrasting

confidence: 60%

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Determining Steady-state Tissue Residues for Invertebrates in Contaminated Sediment

Kennedy¹,

Lotufo²,

Steevens³

et al. 2010

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Risk assessment of contaminated sediments often involves quantification of compounds in tissues via laboratory bioaccumulation exposures of benthic invertebrates. However, the standard 28-day exposure duration may not be adequately long for some compounds to reach steady state, defined as a stable concentration in exposed organisms. Steady-state tissue residues can be estimated using uptake and elimination rate constants. Experiments were conducted using two marine sediments from New York Harbor to assess bioaccumulation of PAHs, PCBs, chlorinated pesticides, dioxins, and Hg by sampling tissue during seven successive time points over an exposure of 56 days for the polychaete worm Nereis virens and 119 days for the clam Macoma nasuta. Exposure time required to attain steady state was organism and compound specific. Generally, N. virens tissues reached steady state more rapidly and accumulated higher contaminant residues. Nereis virens attained apparent steady state within roughly 28 days for PAHs, Hg, and most PCBs, but longer exposure was needed for some dioxins and pesticides. Steady state in M. nasuta was generally attained after 28 days of exposure for most compounds (some times after 100 days). Thus, some 28-day tissue residues may underestimate bioaccumulation and subsequently risk to benthos and higher trophic level organisms. The results of this study allow development of site-specific correction factors for estimating steady-state residues from 28-day exposures.

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Section: Polychlorinated Biphenyls (Pcbs)contrasting

confidence: 87%

Section: Polycyclic Aromatic Hydrocarbons (Pahs)supporting

confidence: 86%

Section: Chlorinated Pesticidescontrasting

confidence: 60%

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Determining Steady-state Tissue Residues for Invertebrates in Contaminated Sediment

Kennedy¹,

Lotufo²,

Steevens³

et al. 2010

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“…A recently developed steady-state partitioning model for bioaccumulation of sediment-associated neutral organics This normalization reduces the variability in BAF values among sediments and organisms [18,. Some authors have used "preference factors," the inverse of AFs [17,20], but AFs are more readily understood as a result of their direct relationship to BAFs.…”

Section: Steady-state Modelsmentioning

confidence: 99%

Toxicokinetics in aquatic systems: Model comparisons and use in hazard assessment

Landrum

Lydy

Lee

1992

Enviro Toxic and Chemistry

Self Cite

348

247

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-Toxicokinetic models are not constrained by assumptions of equilibrium as are thermodynamic (equilibrium-partitioning) models and are more accurate predictors of toxicant accumulation for non-steady-state exposures and multiple uptake routes. Toxicokinetic models -compartmentbased models, physiological-based models, and energetics-based models-are reviewed and the different mathematical formalisms compared. Additionally, the residue-based toxicity approach is reviewed. Coupling toxicokinetic models with tissue concentrations at which toxicity occurs offers a direct link between exposure and hazard. Basing hazard on tissue rather than environmental concentrations avoids the errors associated with accommodating multiple sources, pulsed exposures, and non-steady-state accumulation. Keywords-Kinetic models Bioaccumulation Tissue residue effects Sediment contaminationHazard assessment INTRODUCTlONAssessment and prediction of toxicant effects on aquatic organisms require evaluation of the extent of organism exposure. Exposure assessment establishes the relationship between environmental toxicant concentrations and organism accumulation while accounting for environmental and biological factors that modify exposure. If the relationships between the amount of toxicant accumulated and the resulting effects are known, then the hazard for a particular exposure regime can be established.Aquatic exposure assessments and predictions have employed mainly steady-state and equilibriumpartitioning models. Early efforts, using simple kinetic models, were designed to provide estimates of steady-state accumulation from water exposures [1,2]. These steady-state estimates were then utilized in hazard assessments based on thermodynamic limits (chemical equilibrium). Such models have been employed with good success for evaluation of general conditions, describing toxicant distribution among ecosystem components and *To whom correspondence may be addressed.identifying components dominating toxicant mass balance. This approach has been best refined using the fugacity concept and applied to describe the importance of sediment as a toxicant source [3] and toxicant distributions within ecosystems [4,5].Although there is a continued focus on equilibrium-partitioning models within regulatory agencies, it is clear that the environment is complex and variable. Therefore, to obtain more accurate predictions and assessments, kinetic models are needed to predict non-steady-state, nonequilibrium accumulation from temporally and spatially varying exposures when the simplifying assumptions of the equilibrium-partitioning models are inappropriate, for example, when multiple sources contribute significantly to accumulation.Kinetic models have been used successfully in pharmacology for decades. Such models permit prediction of the onset of drug action and allow the monitoring of drug clearance and termination of effects. Further, these kinetic models describe changes in tissue concentrations resulting from absorption, distribution, metabolism, a...

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“…BSAFs have also been used to compare bioaccumulation across different species and sites, which is further based on the assumption that these factors are independent of species, type of sediment, organic carbon, and contaminant. The present study, and work by others, suggests that these assumptions are not always valid [5,9,16,[29][30][31][32]. Indeed, it has been shown that different fractions of TOC, black carbon in particular, can enhance sorption and decrease bioavailability of contaminants, especially with planar compounds such as PAHs or PCDD/Fs [33][34][35].…”

Section: Comparison: Laboratory and Field Methodsmentioning

confidence: 66%

Validation of Ontario's new laboratory‐based bioaccumulation methods with in situ field data

Geest

Poirier

Sibley

et al. 2011

Enviro Toxic and Chemistry

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Abstract-To validate the standardization of a laboratory protocol for measuring bioaccumulation, laboratory-derived tissue residues and biota-sediment accumulation factors (BSAFs) were compared with historical field data from nine sites in Ontario, Canada. As a result of temporal discontinuity between the field and the laboratory studies, a priori considerations, such as changes in site conditions or concentrations of contaminants in sediment, were necessary to assess whether to compare absolute or relative measures of bioaccumulation. For the majority of sites, BSAFs for field-collected and laboratory-exposed fish were within a factor of 2. Biotasediment accumulation factors for laboratory-exposed oligochaetes were typically greater than those for mussels caged in the field, by a factor of 2 to 9. Overall, the laboratory methods for all species generally overestimated the relative bioavailability of contaminants compared with field conditions by a factor of 1.1 to 9.2. Other than the great disparity observed for polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) between field and laboratory studies, on average the laboratory-derived BSAFs with Pimephales promelas and Lumbriculus variegatus overestimated those from field-collected fish and field-exposed mussels by factors of 1.6 and 3.6, respectively. The laboratory method reflects a potentially worst-case exposure scenario and provides an appropriately conservative estimate of bioaccumulation. Laboratory-based estimates can be comparable to bioaccumulation data from the field but may be confounded by species-specific differences in routes of exposure and bioaccumulation of certain compounds or other environmental and biological factors that should be considered in these comparisons. Environ. Toxicol. Chem. 2011;30:950-958. # 2011 SETAC

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Predicting bioaccumulation potential: A test of a fugacity-based model

Cited by 52 publications

References 29 publications

Determining Steady-state Tissue Residues for Invertebrates in Contaminated Sediment

Determining Steady-state Tissue Residues for Invertebrates in Contaminated Sediment

Toxicokinetics in aquatic systems: Model comparisons and use in hazard assessment

Validation of Ontario's new laboratory‐based bioaccumulation methods with in situ field data

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