Predicting Compensation Voltage for Singly-charged Ions in High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS)

Aksenov, Alexander A.; Kapron, James T.; Davis, Cristina E.

doi:10.1007/s13361-012-0427-6

Cited by 13 publications

(12 citation statements)

References 15 publications

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“…Let p′ be the pressure at the entrance and p 0 that at the exit of the chip channels, respectively. Re-arrange Eqn (16), we obtain the pressure at the entrance as follows (E/N)…”

Section: Gas Number Density N Across a Microchannelmentioning

confidence: 99%

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Precise determination of nonlinear function of ion mobility for explosives and drugs at high electric fields for microchip FAIMS

Guo

Wang

et al. 2015

J. Mass Spectrom.

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High-field asymmetric waveform ion mobility spectrometry (FAIMS) separates ions by utilizing the characteristics of nonlinear ion mobility at high and low electric fields. Accurate ion discrimination depends on the precise solution of nonlinear relationships and is essential for accurate identification of ion species for applications. So far, all the nonlinear relationships of ion mobility obtained are based at low electric fields (E/N <65 Td). Microchip FAIMS (μ-FAIMS) with small dimensions has high electric field up to E/N = 250 Td, making the approximation methods and conclusions for nonlinear relationships inappropriate for these systems. In this paper, we deduced nonlinear functions based on the first principle and a general model. Furthermore we considered the hydrodynamics of gas flow through microchannels. We then calculated the specific alpha coefficients for cocaine, morphine, HMX, TNT and RDX, respectively, based on their FAIMS spectra measured by μ-FAIMS system at ultra-high fields up to 250 Td. The results show that there is no difference in nonlinear alpha functions obtained by the approximation and new method at low field (<120 Td), but the error induced by using approximation method increases monotonically with the increase in field, and could be as much as 30% at a field of 250 Td.

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“…Let p′ be the pressure at the entrance and p 0 that at the exit of the chip channels, respectively. Re-arrange Eqn (16), we obtain the pressure at the entrance as follows (E/N)…”

Section: Gas Number Density N Across a Microchannelmentioning

confidence: 99%

“…[15] However, as a standalone detecting technology, FAIMS is facing several challenges. [16] One of them is to seek for methods to link the compensation voltages, V C , with ion identities (i.e. FAIMS spectral analysis) accurately.…”

Section: Introductionmentioning

confidence: 99%

Precise determination of nonlinear function of ion mobility for explosives and drugs at high electric fields for microchip FAIMS

Guo

Wang

et al. 2015

J. Mass Spectrom.

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“…The DMS device provides orthogonal information to drift-time (DT) IMS methods in that in DMS the ion mobility-related parameter (CV) only weakly correlates with ion size (Aksenov et al, 2012), unlike in DT IMS where ion drift time is essentially linear with the ion cross-section (Borsdorf and Eiceman, 2006, Eiceman and Karpas, 2005). By this, DMS could differentiate two ions which are structurally different but have the same or similar mass and charge such as isomers and isobars.…”

Section: Introductionmentioning

confidence: 99%

A mobile instrumentation platform to distinguish airway disorders

et al. 2013

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Asthma and chronic obstructive pulmonary disease (COPD) are distinct but clinically overlapping airway disorders which often create diagnostic and therapeutic dilemmas. Current strategies to discriminate these diseases are limited by insensitivity and poor performance due to biologic variability. We tested the hypothesis that a gas chromatograph / differential mobility spectrometer (GC/DMS) sensor could distinguish between clinically well-defined groups with airway disorders based on the volatile organic compounds (VOCs) obtained from exhaled breath. After comparing VOC profiles obtained from 13 asthma, 5 COPD, and 13 healthy control subjects, we found that VOC profiles distinguished asthma from healthy controls and also a subgroup of asthmatics taking the drug omalizumab from healthy controls. The VOC profiles could not distinguish between COPD and any of the other groups. Our results show a potential application of the GC/DMS for non-invasive and bedside diagnostics of asthma and asthma therapy monitoring. Future studies will focus on larger sample sizes and patient cohorts.

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“…Ion mobility spectrometry (IMS) is now one of the best techniques for chemical warfare agent's detection [1][2][3][4] especially differential mobility spectrometry (DMS) [5][6][7][8][9][10]. In the past, DMS was called field asymmetric waveform ion mobility spectrometry (FAIMS) [11,12]. DMS is a special method used in ion separation based on difference in ion mobility in high and low electric field under atmospheric pressure [13].…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature on Separation of Sarin (GB) Ions in Differential Mobility Spectrometry

Maziejuk¹,

Ceremuga²,

Szyposzyńska³

et al. 2013

OJPC

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Different environmental conditions in which, equipment based on differential ion mobility spectrometry must operate, forced designers and engineers to analyze the impact of, among other things, external factors on their performance and efficiency. These devices, thanks to the DMS technology, can identify and characterize the ions contained in the gaseous state. However, many areas of this technique remain undiscovered, which should be examined in more detail. One such aspect is the influence of the temperature of gaseous medium, containing tested analyte. The research presented in this article shows why temperature is an important factor on the distribution of generated peaks. The results are shown for different spectra generated carrier gas temperatures (50˚C -80˚C) in which ions were toxic warfare agents. Based on those graphs, it can be stated that increase of the temperature allows for better separation of the peaks from the background. Because of the similar ion mobility of the analyte and background ions for high and low electric field, DMS device can send false alarms, due to the poor interpretations of passing a signal to them. So to be able to accurately assess the level of risk due to the presence of substances BST in air, the test medium was added to isobutanol and isopropanol additives. They help better analyze and separate measured ions.

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Predicting Compensation Voltage for Singly-charged Ions in High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS)

Cited by 13 publications

References 15 publications

Precise determination of nonlinear function of ion mobility for explosives and drugs at high electric fields for microchip FAIMS

Precise determination of nonlinear function of ion mobility for explosives and drugs at high electric fields for microchip FAIMS

A mobile instrumentation platform to distinguish airway disorders

Effect of Temperature on Separation of Sarin (GB) Ions in Differential Mobility Spectrometry

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