Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine

Abstract

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Dopaminergic and Cholinergic Modulation of Large Scale Networks in silico Using Snudda

“…Instead, the dopamine burst and acetylcholine pause produces a larger response. This is contrary to previous results in Lindroos and Hellgren Kotaleski (2021) , where DA and ACh had additive effects when single neurons were simulated. Hence, we performed a simulation with only dSPNs to investigate the effect of DA and ACh.…”

“…modset.define_modulation_parameter accepts the ion channel name, neuromodulator, part of the morphology and the intervals of modulation. Here we have used data from previous publications ( Lindroos et al, 2018 ; Lindroos and Hellgren Kotaleski, 2021 ).…”

“…Neuromodcell and Snudda require multicompartmental models specified for NEURON simulator described by three files: a morphology file (SWC), a parameter file (JSON) and a mechanism file (JSON) including a directory with the ion channel model files (.mod files, NEURON model description language). The models used in this publication were optimized using BluePyOpt ( Van Geit et al, 2016 ) in previous publications ( Hjorth et al, 2020 ; Lindroos and Hellgren Kotaleski, 2021 ) with modification for muscarinic modulation; and include direct and indirect striatal projection neuron (dSPN and iSPN) and fast-spiking interneuron (FS) models from the striatum.…”

“…Furthermore, it has been shown that different parts of a neuron (dendrites/soma) can be modulated differently depending on receptor sub-type and target ( Bender et al, 2010 ). Such compartmental differences can be implemented in multicompartmental models where reconstructed neuronal morphologies are used and ion channel models are distributed throughout the morphology ( Frost Nylén et al, 2020 ; Hjorth et al, 2020 ; Lindroos and Hellgren Kotaleski, 2021 ).…”

Special Issue Editorial: Basal Ganglia/Movement Disorders

“…Two additional studies examined the role of cholinergic interneurons in the regulation of striatal GABAergic projection neurons and interneurons using computational modelling. Lindroos and Kotaleski (2020) used biophysically detailed models of striatal microcircuits to predict that concurrent high intrastriatal acetylcholine and dopamine levels lead to the development of complex spiking patterns in striatal projection neurons. In another study from the same research team, the authors used computational modelling to examine the reciprocal interactions between striatal cholinergic interneurons and low‐threshold spiking (LTS) interneurons.…”