Background
Medication discontinuation is a common result of bariatric surgery.
The influence of individual patient characteristics and surgical outcomes on
overall and specific medication discontinuation is not well understood. The
purpose of the current study was to assess changes in medication use and
identify individual characteristics and surgical outcomes associated with
medication discontinuation among bariatric patients.
Methods
The patients included in the current study received bariatric surgery
from the Northern Colorado Surgical Associates of Fort Collins, Colorado
between October 2007 and September 2010. Demographic, weight, health, and
medication data from 400 patients with at least one 6 or 12 month
post-operative appointment were extracted from the Bariatric Outcome
Longitudinal Database (BOLD). Multivariate regression analyses were used to
investigate how patient factors affect total medication use over time, use
of medications grouped by co-morbidity postoperatively, and use of specific
medication classes post-operatively.
Results
Baseline co-morbidities, particularly type 2 diabetes (T2DM), male
sex, and Roux-en-Y gastric bypass surgery were significantly associated with
decreased total medication use following surgery. Weight loss, systemic
disease, sex, baseline co-morbidities, surgical complications, and race were
significantly associated with continued use of specific medications
following surgery.
Conclusions
Bariatric surgery can help patients with certain characteristics
discontinue medications, but is not effective for all patients. Baseline
health, sex, race, bariatric procedure, surgical complications, and
post-operative weight loss may affect how bariatric patients’
medication use changes pre-operatively to post-operatively.