2020
DOI: 10.4193/rhin20.103
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Predicting difficult-to-treat chronic rhinosinusitis by noninvasive biological markers

et al.

Abstract: Background: Previous studies have been limited to the utility of clinical features and invasive nasal mucosal biomarkers in the prediction of chronic rhinosinusitis (CRS) outcomes. This study aimed to identify noninvasive biomarkers associated with difficultto-treat CRS, enabling physicians to subgroup patients into risk groups for poor outcome before surgery. Methods: Three hundred and nine CRS patients undergoing endoscopic sinus surgery were finally enrolled. Patients treated with oral or intranasal glucoco… Show more

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Cited by 17 publications
(26 citation statements)
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“…Cystatin SN, a cysteine protease inhibitor which enhances IL‐5‐mediated eosinophil activation, in nasal secretions is shown to be an independent predictor of uncontrolled CRSwNP over a 2‐year period 51 . High levels of chemokine C‐C motif ligand 17 (CCL17) and macrophage inflammatory protein (MIP)‐1β in nasal secretions can also predict difficult‐to‐treat CRS 52 . Their utility will need to be validated in further studies.…”
Section: Biomarkersmentioning
confidence: 99%
“…Cystatin SN, a cysteine protease inhibitor which enhances IL‐5‐mediated eosinophil activation, in nasal secretions is shown to be an independent predictor of uncontrolled CRSwNP over a 2‐year period 51 . High levels of chemokine C‐C motif ligand 17 (CCL17) and macrophage inflammatory protein (MIP)‐1β in nasal secretions can also predict difficult‐to‐treat CRS 52 . Their utility will need to be validated in further studies.…”
Section: Biomarkersmentioning
confidence: 99%
“…In studies of Japanese CRSwNP patients with 5 to 8-year follow-up, baseline serum periostin and IgG4 levels were found to predict postoperative recurrence, but had poor performance with an AUC of 0.595 and 0.610, respectively [41,42]. Guo et al [22] conducted a comprehensive study of 35 mediators in plasma including pro-inflammatory cytokines, T cell related cytokines, chemokines and immunoglobulins in CRS patients. They failed to find any difference between patients with and without difficult-to-treat CRS [22].…”
Section: Blood Molecular Markersmentioning
confidence: 99%
“…Guo et al [22] conducted a comprehensive study of 35 mediators in plasma including pro-inflammatory cytokines, T cell related cytokines, chemokines and immunoglobulins in CRS patients. They failed to find any difference between patients with and without difficult-to-treat CRS [22]. Taken together, these results suggest that peripheral blood molecular markers may not have sufficient resolution to capture the difference at mucosal site in CRS patients with different outcomes.…”
Section: Blood Molecular Markersmentioning
confidence: 99%
“…In fact, the most recent guidance from the 2020 European Position Paper on Rhinosinusitis and Nasal Polyps is that primary inflammatory CRS be classified based on whether the patient's disease is due to type-2 inflammation or not, rather than using phenotypic classifications such as the presence of nasal polyps (43) . Endotyping of CRS based on the dominance of type-2 inflammation, which includes eosinophilic inflammation, has been especially shown to be predictive of response to corticosteroids as well as outcomes after endoscopic sinus surgery (132)(133)(134)(135)(136) . Moreover, molecular characterization of CRS endotypes has also allowed for identification of novel biomarkers, for example to identify patients with NSAID-exacerbated respiratory disease (137) or more precisely predict response to specific treatments (138) .…”
Section: Recent Multiomic Approaches Applied To Crs Have Revealed Novel Insights Into the Pathophysiologic Mechanisms Of Crsmentioning
confidence: 99%