Predicting DRESS Syndrome Recurrence—The ReDRESS Score

Sharma, Ajay; Murphy, Kenneth M.; Shwe, Samantha; Miller, Marina; Mesinkovska, Natasha Atanaskova; Rojek, Nathan W.; Worswick, Scott

doi:10.1001/jamadermatol.2022.3491

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…The patients with a total score ≥ 4 represent severe cases with a predilection for later development of CMV diseases and complications ( 168 ). The other risk prediction model developed by Sharma et al included 6 variables (age, sex, rash morphology, facial edema, medication class, and antinuclear antibody positivity) that were associated with the risk of the recurrence of DRESS syndrome ( 169 ). However, these models are derived from relatively small numbers of cases and the generalizability to other populations needs further validation.…”

Section: Prognosis and Potential Biomarkersmentioning

confidence: 99%

Advances in understanding of the pathogenesis and therapeutic implications of drug reaction with eosinophilia and systemic symptoms: an updated review

et al. 2023

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Drug reaction with eosinophilia and systemic symptoms or drug-induced hypersensitivity syndrome (DRESS/DIHS) is one type of severe cutaneous adverse reaction (SCAR). It is featured by fever, widespread skin lesions, protracted clinical course, internal organ involvement, and possibly long-term autoimmune sequelae. The presence of high-risk human leukocyte antigen (HLA) alleles, hypersensitivity reaction after culprit drug ingestion, and human herpesvirus reactivation may all contribute to its complex clinical manifestations. Some recent studies focusing on the roles of involved cytokines/chemokines and T cells co-signaling pathways in DRESS/DIHS were conducted. In addition, some predictors of disease severity and prognosis were also reported. In this review, we provided an update on the current understanding of the pathogenesis, potential biomarkers, and the relevant therapeutic rationales of DRESS/DIHS.

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Section: Prognosis and Potential Biomarkersmentioning

confidence: 99%

Advances in understanding of the pathogenesis and therapeutic implications of drug reaction with eosinophilia and systemic symptoms: an updated review

et al. 2023

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“…This predictive model had a sensitivity of 73% and specificity of 83% for predicting DRESS recurrence. 4 Another case series characterized SCoRCH (sudden conjunctivitis, lymphopenia, sunburnlike rash, and hemodynamic changes), a newly described hypersensitivity reaction to trimethoprim-sulfamethoxazole. 5 The onset of this reaction typically occurs 4 to 11 days after initiation of trimethoprim-sulfamethoxazole but can occur as quickly as 1 day following re-exposure.…”

Section: U T I S D O N O T C O P Ymentioning

confidence: 99%