Predicting factors for progression of the myopia in the MiSight assessment study Spain (MASS)

Abstract

Purpose To investigate which baseline factors are predictive for success in controlling myopia progression in a group of children wearing MiSight Contact Lens (CLs). Methods Myopic patients (n = 41) fitted with MiSight CLs and followed up two years were included in this study. Bivariate analysis, a logistic regression analysis (LG) and a decision tree (DT) approach were used to screen for the factors influencing the success of the treatment. To assess the response, axial length (AL) changes were considered as main variable. Patients were classified based on a specific range of change of axial length at the end of each year of treatment as “responders” (R) (AL change <0.11 mm/per year) and “non-responders” (NR) (AL change ≥0.11 mm/per year). Results Of a total of forty-one Caucasian patients treated with MiSight CLs, 21 and 16 were considered responders in the first and the second year of follow-up, respectively. LG analysis showed that the only factor associated with smaller axial length growth was more time spent outdoors (p = 0.0079) in the first year of treatment. The decision tree analysis showed that in the responding group spending more than 3 and 4 h outdoors per week was associated with the best response in the first year and in the second year of treatment respectively. Conclusions The LR and the DT approach of this pilot study identifies time spent outdoors as a main factor in controlling axial eye growth in children treated with MiSight CLs.

Myopia control with dual‐focus soft contact lenses during the first year of measures to contain the COVID‐19 pandemic

“…Additionally, excessive AL growth is associated with future pathology. Prieto‐Garrido et al 7 defined “responders” to dual‐focus soft contact lens treatment as those with an AL increase of <0.11 mm per year. In the present study, the increase in AL during the 12‐month period in the dual‐focus soft contact lens group was 0.13 mm.…”

“…A recent report proposed that time spent outdoors was the main factor in controlling myopia progression in children using dual-focus soft contact lenses. 7 The association between time spent outdoors and myopia onset is now well established, 11,12 with the most plausible explanation being the increase in dopamine production following sunlight exposure. 13 However, the role of outdoor light exposure and myopia progression remains controversial.…”

Identifying non‐responders to treatments for myopia

“…A number of recent intervention studies designed to slow myopia progression have labelled participants who showed a pattern of fast progression during treatment as non-responders. [1][2][3][4][5] However, we caution against using the terms 'non-responder' and 'fast progressor' interchangeably. The progression of myopia across childhood is often characterised by spurts of fast eye growth interspersed with slower phases.…”

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

“…MiSight's daily lens product was FDA-approved in 2019 for SCLs that slow myopia in children while correcting vision using a concentric ring design. [376,377] According to the NIH, the clinical approval period for this SCL was six years. Another SCL device on the market is the SENSIMED Triggerfish®, which performs intraocular pressure sensing and received FDA approval in 2017.…”