Animal manure is one of the diffusion routes of heavy metals and metalloids into the environment, where the soil can accumulate them. Heavy metals and metalloids can then be released into groundwater sources, be absorbed by crops, and enter the food chain with negative effects for human and animal health. The aim of this study was to evaluate the concentration of heavy metals and mineral nutrients from modern animal rearing systems in order to develop effective strategies to increase the sustainability. Samples of feed (n ¼ 24: n ¼ 16 from swine, n ¼ 8 from cattle), faeces (n ¼ 120: n ¼ 80 from swine, n ¼ 40 from cattle) and water (n ¼ 8), were collected from eight typical intensive swine and cattle farms located in northern Italy. All samples were analysed for the humidity and the principal components. The samples were also dried, mineralised, and analysed by ICP-MS to detect the following elements: Na,