“…Such studies used various analytical methods, including multiple linear regression [Gupta and Christopher, 2009], land-use regression [Beckerman et al, 2013; Vienneau et al, 2010], and mixed effect models [de Hoogh et al, 2018; Kloog et al, 2011; Kloog et al, 2015; Lee et al, 2011; Staffogia et al, 2016]. The last development in this research area is represented by the application of machine learning (ML) algorithms, including various architectures such as random forests [Chen et al, 2018; Di et al, 2019; Staffogia et al, 2019; Yazdi, et al, 2020], neural network [Di et al, 2019; Yazdi, et al, 2020], and gradient boosting [Chen et al, 2019; Di et al, 2019; Just et al, 2018; Zan et al, 2017]. These have demonstrated higher performances, linked with the ability to model any kind of predictor(s)-response association and to deal better with potentially complex relationship between PM 2.5 , spatial, and spatio-temporal predictors [Di, et al, 2019; Polley et al, 2010].…”