Objective: To assess differences in postoperative pain, opioid usage, and surgical outcomes between cranioplasty using abdominal fat graft (AFG) versus hydroxyapatite cement (HAC) following translabyrinthine surgery. Study Design: Retrospective case control. Setting: Tertiary referral center. Patients: Sixty translabyrinthine procedures were evaluated, including 30 consecutive HAC patients and 30 matched AFG patients. Patients were matched by age, gender, body mass index, and tumor size. Intervention: Cranioplasty using HAC or AFG following translabyrinthine resection of vestibular schwannoma. Main Outcome Measures: Postoperative patient pain ratings, narcotic usage, inpatient length of stay, and complication rates. Results: Patients who underwent HAC cranioplasty had lower postoperative pain scores on several measures ( p < 0.05) and less postoperative narcotic usage (mean difference of 36.7 morphine equivalents, p ¼ 0.0025) when compared to those that underwent AFG closure. HAC cranioplasty patients had shorter average length of hospital stay (2.2 vs 3.4 days, p ¼ 0.0441). Postoperative cerebrospinal fluid leaks (one in HAC group, two in AFG group) and skin reactions in AFG closure patients (n ¼ 1) were infrequent. Conclusion: HAC cranioplasty is a safe technique comparable to AFG closure following translabyrinthine surgery which can decrease postoperative pain, narcotic usage, and hospital length of stay.