Predicting Individual Responses to Drug Treatment in Schizophrenia

May, Philip R. A.; Putten, Theodore Van; Yale, Coralee; P, Potepan; Jenden, Donald J.; Fairchild, Mahlon D.; Goldstein, Michael J.; Dixon, W. J.

doi:10.1097/00005053-197603000-00004

Cited by 64 publications

(12 citation statements)

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“…Less than a decade ago doses 10-fold greater than those currently recommended were in common use (Baldessarini CCC OSSS-6222/96/OS0373-05 et al, 1988;Van Putten et al, 1990;Rifkind et al, 1991). A further possible target is to aim at selfreports from subjects as to whether the regime they are on is helpful (May et al, 1976). While highly desirable in many respects, there are ambiguities with this latter target in that subjects may clearly respond in a deceptive fashion and in addition at present there is no consensus among prescribers as to what statements from subjects would qualify as indicating potential responsiveness.…”

Section: Introductionmentioning

confidence: 99%

The Use of the EmotionalStroop Test to Establish the Onset and Efficacy of Antipsychotic Activity

Fear

Healy²

1996

Hum. Psychopharmacol. Clin. Exp.

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North Wales LL57. 2PW.Twenty-eight subjects who met criteria for delusional disorder, of whom 16 were on neuroleptic treatment and 12 were not, were tested using an Emotional Stroop Test to measure aspects of their deployment of attentional resources in response to emotionally valent material. Interference indices were calculated to assess their level of accommodation to depressive, anxiety-related and threat-related words. Those who were on neuroleptics demonstrated significantly less interference from anxiety and threat-related words, raising the possibility that this test might provide a sensitive measure of the onset and efficacy of antipsychotic activity. The differential effects on anxiety and threat-related words also suggest that the antipsychotic activity of current neuroleptics is nonspecifically tranquilking rather than specifically psychotolytic in nature.

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Section: Introductionmentioning

confidence: 99%

The Use of the EmotionalStroop Test to Establish the Onset and Efficacy of Antipsychotic Activity

Fear

Healy²

1996

Hum. Psychopharmacol. Clin. Exp.

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“…We describe the subjective responses of schizophrenic patients to a test dose of thiothixene and discuss the following concerns: (1) the implications of a dysphoric response, (2) prediction of dysphoric response, (3) possible mechanisms of dysphoric response, and (4) prevention of dysphoric response.…”

mentioning

confidence: 99%

Subjective Response to Antipsychotic Drugs

Putten¹

1981

Arch Gen Psychiatry

216

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“…Dysphorische Reaktionen im gesamten Verlauf einer Neuroleptikatherapie sind von vielen Autoren beschrieben worden [25].Begriffe wie "pharmakogene Depression" [15],"akinetische Depression" [42], "neuroleptisches dyskognitives Syndrom" [14],"dyskognitiv-apathische Nebenwirkungen" [22], "behavioral toxicity" [47], "mentale Begleitwirkung von extrapyramidal-motorischen Störungen" [10],"neuroleptikainduziertes Defizitsyndrom" [26] oder "kognitiver und emotionaler Parkinsonismus" [28] [29,43]; Studiendetails s.⊡ Tabelle 1).In dieser prospektiven Studie ist eine IDR die negative Ausprägung eines synton-dysphorischen Kontinuums subjektiver Reaktionen und zeigt sich durch eine ängstlich-ablehnende Stimmung bis hin zu tiefer Verstörtheit und panischen Reaktionen. Das Neuroleptikum wird als negativ und wenig hilfreich erlebt.…”

Section: Definition Der Initial Dysphorischen Reaktion (Idr)unclassified

Die initial dysphorische Reaktion (IDR) auf die Ersteinnahme von Neuroleptika

et al. 2004

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Initial dysphoric response (IDR) is characterized by a negative affective reaction within 48 h after a neuroleptic test dose. Currently, there are three scales for measuring the IDR (Neuroleptic Dysphoria Scale, Dysphoric Response Index, Drug Attitude Inventory). The debate continues about the definition, measurement, and underlying aetiology of IDR. Nevertheless, with a prevalence of 30%, the response is a clinically relevant phenomenon. Empirical data give some evidence of an association between IDR and short-term outcome. No correlation of IDR with pretreatment variables has been found yet (e.g. age, gender, and psychopathology at baseline, especially depression and hostility). With respect to aetiology, a negative subjective reaction to concurrent extrapyramidal side effects and direct dysaffective effects of some neuroleptics have been discussed. Other studies found that IDR might not be a specifically antipsychotic effect. Our first results give some evidence that patients treated with atypical antipsychotics experience IDR less often and less severely than those treated with conventional antipsychotics described in the literature. Further research should include placebo-controlled studies and the evaluation of specific pretreatment variables. To assess the aetiology of IDR, further basic research is needed.

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Predicting Individual Responses to Drug Treatment in Schizophrenia

Cited by 64 publications

References 0 publications

The Use of the EmotionalStroop Test to Establish the Onset and Efficacy of Antipsychotic Activity

The Use of the EmotionalStroop Test to Establish the Onset and Efficacy of Antipsychotic Activity

Subjective Response to Antipsychotic Drugs

Die initial dysphorische Reaktion (IDR) auf die Ersteinnahme von Neuroleptika

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