Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer

Abstract

Background: We investigated the usefulness of the minimum ADC value of primary breast lesions for predicting axillary lymph node (LN) status in luminal Alike breast cancers with clinically negative nodes in comparison with the mean ADC. Methods: Forty-four luminal Alike breast cancers without axillary LN metastasis at preoperative clinical evaluation, surgically resected with sentinel LN biopsy, were retrospectively studied. Mean and minimum ADC values of each lesion were measured and statistically compared between LN-positive (n = 12) and LN-negative (n = 32) groups. An ROC curve was drawn to determine the best cutoff value to differentiate LN status. Correlations between mean and minimum ADC values and the number of metastatic axillary LNs were investigated. Results: Mean and minimum ADC values of breast lesions with positive LN were significantly lower than those with negative LN (mean: 839.9 ± 110.9 vs. 1022.2 ± 250.0 × 10-6 mm 2 /s, p = 0.027, minimum: 696.7 ± 128.0 vs. 925.0 ± 257.6 × 10-6 mm 2 /s, p = 0.004). The sensitivity and NPV using the best cutoff value from ROC using both mean and minimum ADC were 100%. AUC of the minimum ADC (0.784) was higher than that of the mean ADC (0.719). Statistically significant negative correlations were observed between both mean and minimum ADCs and number of positive LNs, with p. 2 stronger correlation to minimum ADC than mean ADC. Conclusions: The minimum ADC value of primary breast lesions predicts axillary LN metastasis in luminal Alike breast cancer with clinically negative nodes, with high sensitivity and high NPV.

Preoperative Prediction Value of Pelvic Lymph Node Metastasis of Endometrial Cancer: Combining of ADC Value and Radiomics Features of the Primary Lesion and Clinical Parameters

“…Investigators found ADC value of LNs was unable to differentiate benign LNs from malignant LNs [ 20 , 21 ]. However, several reports showed that the ADC value of breast lesions in patients with positive axillary LN metastasis was significantly lower than those with negative axillary LNM [ 22 ]. Therefore, our study focused on the ADC value of EC primary lesion in different LN states and found that ADC value showed inverse correlation with PLNM.…”

Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC)

“…Although several studies have investigated the diagnostical role of 18F-FDG and ADC for determining tumor aggressiveness in different cancers [32,[37][38][39][40][41][42], none of the studies have compared the efficacy of different PET/MRI imaging biomarkers in HNC tumor aggressiveness prediction. Thus, to our knowledge, this is the first study to compare PET/MRI system-derived imaging parameters in lymph node involvement in HNC.…”

Predictive value of triple negative breast cancer based on DCE-MRI multi-phase full-volume ROI clinical radiomics model

“…In contrast, the Washout median was higher than in patients with NTNBC, indicating that MRI multiparametric imaging is useful for typing prediction of breast cancer. Nonetheless, the literature reveals lower ADC values in patients with TNBC than in patients with NTNBC (30). The differences between the findings may be related to b-value selection, field strength size, ROI outlining method, and so on.…”