Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers

İliaz, Raim; Özpolat, Tahsin; Baran, Bülent; Demır, Kadir; Kaymakoğlu, Sabahattin; Beşışık, Fatih; Akyüz, Filiz

doi:10.1097/meg.0000000000001111

Cited by 31 publications

(30 citation statements)

References 26 publications

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“…As regard WBCs differentials, we found that the blood neutrophils have high significant values in the SBP group compared with non-SBP as neutrophil is the key cellular component of host defense in the innate immune system against infectious injury, that in agreement with Iliaz et al,. We found also that lymphocyte values were lower in the SBP group with insignificant difference which can be explained by loss of lymphocytes due to continuous sepsis-induced apoptosis that in agreement with Iliaz et al [11].…”

Section: Discussionsupporting

confidence: 92%

“…While regarding the albumin level, we found no significant differences between the studied groups that agreed with Iliaz et al [11].…”

Section: Fig 1 Positive Correlation Between Nlr Car and Ascitic Neutrophil Count After Sbp Treatmentsupporting

confidence: 92%

“…In our study, NLR and CAR were significantly higher in patients with the SBP group than patients without the SBP group before treatment. These results were supported by data revealed by Iliaz et al [11].…”

Section: Fig 1 Positive Correlation Between Nlr Car and Ascitic Neutrophil Count After Sbp Treatmentsupporting

confidence: 90%

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Blood Neutrophil / Lymphocyte Ratio and C –Reactive Protein / Albumin Ratio as Markers of Response for Treatment of Spontaneous Bacterial Peritonitis

Mustafa

Mabrouk

Saif

et al. 2021

IJTDH

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Background: Spontaneous bacterial peritonitis (SBP) is an acute infection of ascites with the absence of surgically treatable cause and the gold standard method in its diagnosis is the presence of 250 polymorphonuclear neutrophils (PMN) /mm3 or more by diagnostic paracentesis. Blood neutrophil/lymphocytic ratio (NLR) is an applicable, inexpensive, and simple test for inflammation. C-reactive protein/albumin ratio (CAR) is an inflammatory marker used for the diagnosis and follow-up of many diseases and morbidities. We aimed to evaluate the clinical utility of both blood NLR and CAR as applicable, simple and non-invasive tests for SBP follow-up. Patients and Methods: This study was done on 80 cirrhotic ascitic patients attending the Tropical Medicine Department of Tanta University Hospital. They were subjected to full history taking, clinical examination, laboratory investigations, and ascitic fluid analysis. The patients were divided into two groups according to the results of diagnostic paracentesis into group I: 40 cirrhotic ascitic patients without spontaneous bacterial peritonitis and group II: 40 cirrhotic ascitic patients with spontaneous bacterial peritonitis, and then SBP group were tested after treatment by third-generation cephalosporin for five days for ascitic sample, NLR and CAR. Results: Both blood NLR and CAR were significantly higher in SBP patients. Also, a significant decrease in both ratios was observed post-treatment with significant positive correlations between both NLR and CAR with ascitic neutrophil count after SBP treatment. Conclusion: NLR and CAR can be used as quick, cheap, and applicable markers of the response of treatment in SBP patients.

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Section: Discussionsupporting

confidence: 92%

“…While regarding the albumin level, we found no significant differences between the studied groups that agreed with Iliaz et al [11].…”

Section: Fig 1 Positive Correlation Between Nlr Car and Ascitic Neutrophil Count After Sbp Treatmentsupporting

confidence: 92%

See 1 more Smart Citation

Blood Neutrophil / Lymphocyte Ratio and C –Reactive Protein / Albumin Ratio as Markers of Response for Treatment of Spontaneous Bacterial Peritonitis

Mustafa

Mabrouk

Saif

et al. 2021

IJTDH

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“…Hospitalized patients with infection also exhibited significantly higher NLR values. Similar to these results, Lliaz et al demonstrated higher NLR values in patients with cirrhosis diagnosed with spontaneous bacterial peritonitis (29) . A retrospective Chinese study identified that the NLR assessed at admission was an independent predictor of hospital-acquired bacterial infections (30) .…”

Section: Discussionsupporting

confidence: 66%

Neutrophil-Lymphocyte Ratio Predicts Short-Term Mortality in Patients Hospitalized for Acute Decompensation of Cirrhosis

Maccali

Augustinho

Zocche

et al. 2021

Arq. Gastroenterol.

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BACKGROUND: Individuals with cirrhosis have a chronic systemic inflammation associated with an immune dysfunction, affecting the progression of the liver disease. The neutrophil-lymphocyte ratio (NLR) was proposed as a marker of systemic inflammatory response and survival in patients with cirrhosis. OBJECTIVE: Evaluate the prognostic role of NLR in cirrhotic patients and its relation with inflammatory cytokines(IL-6, IL-10 and IL-17). METHODS: In this prospective study two groups were evaluated: 1) Stable cirrhotic in outpatient follow-up (n=193); 2) Hospitalized cirrhotic for acute decompensation for at least 48 hours (n=334) with admission and 48 hours tests evaluation. Circulating inflammatory cytokines were available for 130 hospitalized patients. RESULTS: In outpatients with stable cirrhosis, NLR correlated with MELD score and other variables associated with severity of disease. However, after a median of 32 months of follow up NLR was not associated with mortality (HR 1.058, 95%CI 0.900-1.243; P=0.495). In hospitalized patients, NLR at 48-hour after admission was independently associated with 90-day survival (HR 1.061, 95%CI 1.020-1.103; P=0.003) in multivariate Cox-regression analysis. The 90-day Kaplan-Meier survival probability was 87% for patients with a 48-hour NLR <3.6 and 62% for NLR ≥3.6 (P<0.001). Elevation of NLR in the first 48 hours was also independently associated with mortality (HR 2.038, 95%CI 1295-3207; P=0.002). The 90-day Kaplan-Meier survival probability was 83% when NLR did not increase and 62% when NLR increased (P<0.001). IL-6, IL-10 and IL-17 at admission were positively correlated with both admission and 48-hour NLR. Lower levels of baseline IL-10 were associated with NLR increase during first 48-hour. CONCLUSION: NLR evaluated at 48 hours of hospitalization and its early increase after admission were independently associated with short-term mortality in patients hospitalized for acute decompensation of cirrhosis.

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“…Spontaneous bacterial peritonitis (SBP) is a common and life-threatening complication in patients with cirrhosis, associated with significant morbidity and mortality [1]. The hospital mortality in hospitalized patients with cirrhosis and SBP ranges from 20% to 40% in different investigations [2][3][4][5]. Due to their poor prognosis, patients with cirrhosis and SBP often need to be admitted to the intensive care unit (ICU).…”

Section: Introductionmentioning

confidence: 99%

Acute kidney injury in critically ill cirrhotic patients with spontaneous bacterial peritonitis: a comparison of KDIGO and ICA criteria

Xiong¹,

Zhang²,

Guo³

et al. 2020

aoms

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Predicting mortality in patients with spontaneous bacterial peritonitis using routine inflammatory and biochemical markers

Abstract: Our results suggest that SBP has high 30-day mortality. MELD scores and inflammatory markers (CRP, CRP albumin ratio, neutrophil-lymphocyte ratio) may be used to predict mortality in patients with SBP.

Cited by 31 publications

References 26 publications

Blood Neutrophil / Lymphocyte Ratio and C –Reactive Protein / Albumin Ratio as Markers of Response for Treatment of Spontaneous Bacterial Peritonitis

Blood Neutrophil / Lymphocyte Ratio and C –Reactive Protein / Albumin Ratio as Markers of Response for Treatment of Spontaneous Bacterial Peritonitis

Neutrophil-Lymphocyte Ratio Predicts Short-Term Mortality in Patients Hospitalized for Acute Decompensation of Cirrhosis

Acute kidney injury in critically ill cirrhotic patients with spontaneous bacterial peritonitis: a comparison of KDIGO and ICA criteria

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